Harada CN, Natelson Love MC, Triebel KL. Normal cognitive aging. Clin Geriatr Med. 2013;29(4):737–52.
Article PubMed PubMed Central Google Scholar
Aaldijk E, Vermeiren Y. The role of serotonin within the microbiota-gut-brain axis in the development of Alzheimer’s disease: a narrative review. Ageing Res Rev. 2022;75: 101556.
Article PubMed CAS Google Scholar
Mayer E, Nance K, Chen S. The Gut-Brain Axis. Annu Rev Med. 2022;73:439–53.
Chen C, Liao J, Xia Y, Liu X, Jones R, Haran J, et al. Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation. Gut. 2022;71(11):2233–52.
Dodiya H, Lutz H, Weigle I, Patel P, Michalkiewicz J, Roman-Santiago C, et al. Gut microbiota-driven brain Aβ amyloidosis in mice requires microglia. J Exp Med. 2022;219(1):e20200895.
Article PubMed CAS Google Scholar
Agirman G, Yu K, Hsiao E. Signaling inflammation across the gut-brain axis. Science (New York, NY). 2021;374(6571):1087–92.
Grizotte-Lake M, Zhong G, Duncan K, Kirkwood J, Iyer N, Smolenski I, et al. Commensals suppress intestinal epithelial cell retinoic acid synthesis to regulate interleukin-22 activity and prevent microbial dysbiosis. Immunity. 2018;49(6):1103-15.e6.
Article PubMed PubMed Central CAS Google Scholar
Huber S, Gagliani N, Esplugues E, O’Connor W, Huber F, Chaudhry A, et al. Th17 cells express interleukin-10 receptor and are controlled by Foxp3- and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity. 2011;34(4):554–65.
Article PubMed PubMed Central CAS Google Scholar
Chaudhry A, Rudra D, Treuting P, Samstein R, Liang Y, Kas A, et al. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science (New York, NY). 2009;326(5955):986–91.
Park S, Mathur R, Long M, Hosh N, Hao L, Hayden M, et al. T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells. Immunity. 2010;33(5):791–803.
Article PubMed PubMed Central CAS Google Scholar
Hall J, Cannons J, Grainger J, Dos Santos L, Hand T, Naik S, et al. Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha. Immunity. 2011;34(3):435–47.
Article PubMed PubMed Central CAS Google Scholar
Hill J, Hall J, Sun C, Cai Q, Ghyselinck N, Chambon P, et al. Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity. 2008;29(5):758–70.
Article PubMed PubMed Central CAS Google Scholar
Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science (New York, NY). 2007;317(5835):256–60.
Benson M, Pino-Lagos K, Rosemblatt M, Noelle R. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med. 2007;204(8):1765–74.
Article PubMed PubMed Central CAS Google Scholar
Nolting J, Daniel C, Reuter S, Stuelten C, Li P, Sucov H, et al. Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. J Exp Med. 2009;206(10):2131–9.
Article PubMed PubMed Central CAS Google Scholar
Taylor B, Dager A, Panza G, Zaleski A, Meda S, Book G, et al. The effect of high-dose atorvastatin on neural activity and cognitive function. Am Heart J. 2018;197:166–74.
Article PubMed CAS Google Scholar
Muldoon M, Ryan C, Sereika S, Flory J, Manuck S. Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults. Am J Med. 2004;117(11):823–9.
Article PubMed CAS Google Scholar
Sinyavskaya L, Gauthier S, Renoux C, Dell’Aniello S, Suissa S, Brassard P. Comparative effect of statins on the risk of incident Alzheimer disease. Neurology. 2018;90(3):e179–87.
Article PubMed CAS Google Scholar
Shepherd J, Blauw G, Murphy M, Bollen E, Buckley B, Cobbe S, et al. Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial. Lancet (London, England). 2002;360(9346):1623–30.
Meade THPSCGi. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. ACC Current Journal Review. 2002;360(9326):39–40.
Ott B, Daiello L, Dahabreh I, Springate B, Bixby K, Murali M, et al. Do statins impair cognition? a systematic review and meta-analysis of randomized controlled trials. J Gen Intern Med. 2015;30(3):348–58.
Article PubMed PubMed Central Google Scholar
Zhou Z, Ryan J, Ernst M, Zoungas S, Tonkin A, Woods R, et al. Effect of statin therapy on cognitive decline and incident dementia in older adults. J Am Coll Cardiol. 2021;77(25):3145–56.
Article PubMed CAS Google Scholar
Wong W, Lin V, Boudreau D, Devine E. Statins in the prevention of dementia and Alzheimer’s disease: a meta-analysis of observational studies and an assessment of confounding. Pharmacoepidemiol Drug Saf. 2013;22(4):345–58.
Article PubMed CAS Google Scholar
Schilling S, Tzourio C, Soumaré A, Kaffashian S, Dartigues J, Ancelin M, et al. Differential associations of plasma lipids with incident dementia and dementia subtypes in the 3C study: a longitudinal, population-based prospective cohort study. PLoS Med. 2017;14(3): e1002265.
Article PubMed PubMed Central Google Scholar
Heymann A, Ravona-Springer R, Moshier E, Godbold J, Beeri M. Statin use is associated with better cognitive function in elderly with type 2 diabetes. Journal of Alzheimer’s disease: JAD. 2015;47(1):55–9.
Article PubMed CAS Google Scholar
Zhang Y, Fan Y, Wang M, Wang D, Li X. Atorvastatin attenuates the production of IL-1β, IL-6, and TNF-α in the hippocampus of an amyloid β1-42-induced rat model of Alzheimer’s disease. Clin Interv Aging. 2013;8:103–10.
PubMed PubMed Central CAS Google Scholar
Kurihara M, Mano T, Saito Y, Murayama S, Toda T, Iwata A. Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies. Brain Sci. 2019;10(1):7.
Article PubMed Central Google Scholar
Magoč T, Salzberg S. FLASH: fast length adjustment of short reads to improve genome assemblies. Bioinformatics (Oxford, England). 2011;27(21):2957–63.
Bokulich N, Subramanian S, Faith J, Gevers D, Gordon J, Knight R, et al. Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing. Nat Methods. 2013;10(1):57–9.
Article PubMed CAS Google Scholar
Hurst R, Else K. The retinoic acid-producing capacity of gut dendritic cells and macrophages is reduced during persistent T. muris infection. Parasite Immunol. 2013;35:229–33.
Article PubMed PubMed Central CAS Google Scholar
Jaensson E, Uronen-Hansson H, Pabst O, Eksteen B, Tian J, Coombes J, et al. Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans. J Exp Med. 2008;205(9):2139–49.
Article PubMed PubMed Central CAS Google Scholar
Vicente-Suarez I, Larange A, Reardon C, Matho M, Feau S, Chodaczek G, et al. Unique lamina propria stromal cells imprint the functional phenotype of mucosal dendritic cells. Mucosal Immunol. 2015;8(1):141–51.
Article PubMed CAS Google Scholar
Steele M, Stuchbury G, Münch G. The molecular basis of the prevention of Alzheimer’s disease through healthy nutrition. Exp Gerontol. 2007;42:28–36.
Article PubMed CAS Google Scholar
Blurton-Jones M, Laferla F. Pathways by which Abeta facilitates tau pathology. Curr Alzheimer Res. 2006;3(5):437–48.
Article PubMed CAS Google Scholar
Sastre M, Dewachter I, Landreth G, Willson T, Klockgether T, van Leuven F, et al. Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003;23(30):9796–804.
Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, et al. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric abeta, and frank neuronal loss. J Neurosci. 2013;33(15):6245–56.
留言 (0)