Tscharke DC, Croft NP, Doherty PC, La Gruta NL. Sizing up the key determinants of the CD8(+) T cell response. Nat Rev Immunol. 2015;15(11):705–16.

Article  CAS  PubMed  Google Scholar 

Reina-Campos M, Scharping NE, Goldrath AW. CD8(+) T cell metabolism in infection and cancer. Nat Rev Immunol. 2021;21(11):718–38.

Article  PubMed  PubMed Central  Google Scholar 

Akondy RS, Fitch M, Edupuganti S, Yang S, Kissick HT, Li KW, et al. Origin and differentiation of human memory CD8 T cells after vaccination. Nature. 2017;552(7685):362–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grant EJ, Quinones-Parra SM, Clemens EB, Kedzierska K. Human influenza viruses and CD8(+) T cell responses. Curr Opin Virol. 2016;16:132–42.

Article  CAS  PubMed  Google Scholar 

Zuniga EI, Macal M, Lewis GM, Harker JA. Innate and adaptive immune regulation during chronic viral infections. Annu Rev Virol. 2015;2(1):573–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pawelec G. Immunosenenescence: role of cytomegalovirus. Exp Gerontol. 2014;54:1–5.

Article  CAS  PubMed  Google Scholar 

Sansoni P, Vescovini R, Fagnoni FF, Akbar A, Arens R, Chiu YL, et al. New advances in CMV and immunosenescence. Exp Gerontol. 2014;55:54–62.

Article  PubMed  Google Scholar 

Nikolich-Zugich J, Cicin-Sain L, Collins-McMillen D, Jackson S, Oxenius A, Sinclair J, et al. Advances in cytomegalovirus (CMV) biology and its relationship to health, diseases, and aging. Geroscience. 2020;42(2):495–504.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hassouneh F, Goldeck D, Pera A, van Heemst D, Slagboom PE, Pawelec G, et al. Functional changes of T-cell subsets with age and CMV infection. Int J Mol Sci. 2021;22(18):9973–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dioverti MV, Razonable RR. Cytomegalovirus. Microbiol Spectr. 2016;4:4.

Article  Google Scholar 

Staras SA, Dollard SC, Radford KW, Flanders WD, Pass RF, Cannon MJ. Seroprevalence of cytomegalovirus infection in the United States, 1988-1994. Clin Infect Dis. 2006;43(9):1143–51.

Article  PubMed  Google Scholar 

Miles DJ, Sanneh M, Holder B, Crozier S, Nyamweya S, Touray ES, et al. Cytomegalovirus infection induces T-cell differentiation without impairing antigen-specific responses in Gambian infants. Immunology. 2008;124(3):388–400.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klenerman P, Oxenius A. T cell responses to cytomegalovirus. Nat Rev Immunol. 2016;16(6):367–77.

Article  CAS  PubMed  Google Scholar 

Dunn W, Chou C, Li H, Hai R, Patterson D, Stolc V, et al. Functional profiling of a human cytomegalovirus genome. Proc Natl Acad Sci U S A. 2003;100(24):14223–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cunningham C, Gatherer D, Hilfrich B, Baluchova K, Dargan DJ, Thomson M, et al. Sequences of complete human cytomegalovirus genomes from infected cell cultures and clinical specimens. J Gen Virol. 2010;91(Pt 3):605–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reus B, Caserta S, Larsen M, Morrow G, Bano A, Hallensleben M, et al. In-depth profiling of T-cell responsiveness to commonly recognized CMV antigens in older people reveals important sex differences. Front Immunol. 2021;12:707830.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sylwester A, Nambiar KZ, Caserta S, Klenerman P, Picker LJ, Kern F. A new perspective of the structural complexity of HCMV-specific T-cell responses. Mech Ageing Dev. 2016;158:14–22.

Article  CAS  PubMed  Google Scholar 

Sylwester AW, Mitchell BL, Edgar JB, Taormina C, Pelte C, Ruchti F, et al. Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med. 2005;202(5):673–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vescovini R, Fagnoni FF, Telera AR, Bucci L, Pedrazzoni M, Magalini F, et al. Naive and memory CD8 T cell pool homeostasis in advanced aging: impact of age and of antigen-specific responses to cytomegalovirus. Age. 2014;36(2):625–40.

Article  CAS  PubMed  Google Scholar 

Acuto O, Michel F. CD28-mediated co-stimulation: a quantitative support for TCR signalling. Nat Rev Immunol. 2003;3(12):939–51.

Article  CAS  PubMed  Google Scholar 

Grant EJ, Nussing S, Sant S, Clemens EB, Kedzierska K. The role of CD27 in anti-viral T-cell immunity. Curr Opin Virol. 2017;22:77–88.

Article  CAS  PubMed  Google Scholar 

Ueda Y, Levine BL, Huang ML, Freeman GJ, Nadler LM, June CH, et al. Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion. Int Immunol. 1995;7:957–66.

Article  CAS  PubMed  Google Scholar 

Weng NP, Akbar AN, Goronzy J. CD28(-) T cells: their role in the age-associated decline of immune function. Trends Immunol. 2009;30(7):306–12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Riddell NE, Griffiths SJ, Rivino L, King DC, Teo GH, Henson SM, et al. Multifunctional cytomegalovirus (CMV)-specific CD8 T cells are not restricted by telomere-related senescence in young or old adults. Immunology. 2014.

Denoeud J, Moser M. Role of CD27/CD70 pathway of activation in immunity and tolerance. J Leukocyte Biol. 2011;89(2):195–203.

Article  CAS  PubMed  Google Scholar 

van Gisbergen KP, Klarenbeek PL, Kragten NA, Unger PP, Nieuwenhuis MB, Wensveen FM, et al. The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants. Immunity. 2011;35(1):97–108.

Article  PubMed  Google Scholar 

Welten SP, Redeker A, Franken KL, Benedict CA, Yagita H, Wensveen FM, et al. CD27-CD70 costimulation controls T cell immunity during acute and persistent cytomegalovirus infection. J Virol. 2013;87(12):6851–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deola S, Panelli MC, Maric D, Selleri S, Dmitrieva NI, Voss CY, et al. Helper B cells promote cytotoxic T cell survival and proliferation independently of antigen presentation through CD27/CD70 interactions. J Immunol. 2008;180(3):1362–72.

Article  CAS  PubMed  Google Scholar 

Arens R, Schepers K, Nolte MA, van Oosterwijk MF, van Lier RA, Schumacher TN, et al. Tumor rejection induced by CD70-mediated quantitative and qualitative effects on effector CD8+ T cell formation. J Exp Med. 2004;199(11):1595–605.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang D, Du J, Song Y, Wang B, Song R, Hao Y, et al. CD70 contributes to age-associated T cell defects and overwhelming inflammatory responses. Aging. 2020;12(12):12032–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oelke M, Maus MV, Didiano D, June CH, Mackensen A, Schneck JP. Ex vivo induction and expansion of antigen-specific cytotoxic T cells by HLA-Ig-coated artificial antigen-presenting cells. Nat Med. 2003;9(5):619–24.

Article  CAS  PubMed  Google Scholar 

Arens R, Nolte MA, Tesselaar K, Heemskerk B, Reedquist KA, van Lier RA, et al. Signaling through CD70 regulates B cell activation and IgG production. J Immunol. 2004;173(6):3901–8.

Article  CAS  PubMed  Google Scholar 

Taraban VY, Rowley TF, Al-Shamkhani A. Cutting edge: a critical role for CD70 in CD8 T cell priming by CD40-licensed APCs. J Immunol. 2004;173(11):6542–6.

Article  CAS  PubMed  Google Scholar 

Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, et al. CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase. J Biol Chem. 1998;273(21):13353–8.

Article  CAS  PubMed  Google Scholar 

Gravestein LA, Amsen D, Boes M, Calvo CR, Kruisbeek AM, Borst J. The TNF receptor family member CD27 signals to Jun N-terminal kinase via Traf-2. Eur J Immunol. 1998;28(7):2208–16.

Article  CAS  PubMed  Google Scholar 

Al Sayed MF, Ruckstuhl CA, Hilmenyuk T, Claus C, Bourquin JP, Bornhauser BC, et al. CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies. Blood.