Povidone-Iodine Fails to Eradicate Chronic Suppurative Otitis Media and Demonstrates Ototoxic Risk in Mice

∗Department of Otolaryngology, Head and Neck Surgery, Stanford University, Palo Alto, California

†Department of Otorhinolaryngology, Head and Neck Surgery, King George's Medical University, Lucknow, India

‡Department of Microbiology and Immunology, Dartmouth University, Hanover, New Hampshire

Address correspondence and reprint requests to Peter L. Santa Maria, M.B.B.S., Ph.D., Department of Otolaryngology, Head and Neck Surgery, Stanford University, 801 Welch Road, Palo Alto, CA 94304; E-mail: [email protected]

Sources of support and disclosure of funding: Stanford Maternal and Child Health Research Institute and Stanford SPARK therapeutic translational program.

Conflicts of interest: P.L.S.M., L.A.B., and A.X. are inventors on patents for treatments for chronic suppurative otitis media currently owned by Stanford University.

Author contributions: P.L.S.M., A.C.K., L.A.B., A.X., B.S.B., and B.B. conceived the study and designed and interpreted experiments. A.C.K., L.A.B., B.S.B., MW, B.B., and D.S. performed and analyzed experiments. P.L.S.M., A.C.K., B.S.B., and B.B. edited the manuscript.

Supplemental digital content is available in the text.

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