H. Sung, J. Ferlay, R.L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, F. Bray, Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 Countries. CA Cancer J. Clin. 71, 209–249 (2021)

Article  PubMed  Google Scholar 

R.S. Herbst, D. Morgensztern, C. Boshoff, The biology and management of non-small cell lung cancer. Nature 553, 446–454 (2018)

Article  CAS  PubMed  Google Scholar 

S. Revathidevi, A.K. Munirajan, Akt in cancer: mediator and more. Semin. Cancer Biol. 59, 80–91 (2019)

Article  CAS  PubMed  Google Scholar 

B.D. Manning, L.C. Cantley, AKT/PKB signaling: navigating downstream. Cell 129, 1261–1274 (2007)

Article  CAS  PubMed  PubMed Central  Google Scholar 

B.R. Balsara, J. Pei, Y. Mitsuuchi, R. Page, A. Klein-Szanto, H. Wang, M. Unger, J.R. Testa, Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions. Carcinogenesis 25, 2053–2059 (2004)

Article  CAS  PubMed  Google Scholar 

Y. Guo, J. Du, D.J. Kwiatkowski, Molecular dissection of AKT activation in lung cancer cell lines. Mol. Cancer Res. 11, 282–293 (2013)

Article  CAS  PubMed  PubMed Central  Google Scholar 

M.C. Crouthamel, J.A. Kahana, S. Korenchuk, S.Y. Zhang, G. Sundaresan, D.J. Eberwein, K.K. Brown, R. Kumar, Mechanism and management of AKT inhibitor-induced hyperglycemia. Clin. Cancer Res. 15, 217–225 (2009)

Article  CAS  PubMed  Google Scholar 

S.F. Barnett, D. Defeo-Jones, S. Fu, P.J. Hancock, K.M. Haskell, R.E. Jones, J.A. Kahana, A.M. Kral, K. Leander, L.L. Lee, J. Malinowski, E.M. McAvoy, D.D. Nahas, R.G. Robinson, H.E. Huber, Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. Biochem. J. 385, 399–408 (2005)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J.M. Suski, M. Braun, V. Strmiska, P. Sicinski, Targeting cell-cycle machinery in cancer. Cancer Cell 39, 759–778 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

R.S. Finn, J.P. Crown, I. Lang, K. Boer, I.M. Bondarenko, S.O. Kulyk, J. Ettl, R. Patel, T. Pinter, M. Schmidt, Y. Shparyk, A.R. Thummala, N.L. Voytko, C. Fowst, X. Huang, S.T. Kim, S. Randolph, D.J. Slamon, The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study. Lancet Oncol. 16, 25–35 (2015)

Article  CAS  PubMed  Google Scholar 

R.S. Finn, M. Martin, H.S. Rugo, S. Jones, S.A. Im, K. Gelmon, N. Harbeck, O.N. Lipatov, J.M. Walshe, S. Moulder, E. Gauthier, D.R. Lu, S. Randolph, V. Dieras, D.J. Slamon, Palbociclib and Letrozole in advanced breast cancer. N. Engl. J. Med. 375, 1925–1936 (2016)

Article  CAS  PubMed  Google Scholar 

N.C. Turner, C. Huang Bartlett, M. Cristofanilli, Palbociclib in hormone-receptor-positive advanced breast cancer. N. Engl. J. Med. 373, 1672–1673 (2015)

Article  PubMed  Google Scholar 

R.N. Booher, P.S. Holman, A. Fattaey, Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. J. Biol. Chem. 272, 22300–22306 (1997)

Article  CAS  PubMed  Google Scholar 

J.Y. Zhu, R.A. Cuellar, N. Berndt, H.E. Lee, S.H. Olesen, M.P. Martin, J.T. Jensen, G.I. Georg, E. Schonbrunn, Structural basis of Wee kinases functionality and inactivation by diverse small molecule inhibitors. J. Med. Chem. 60, 7863–7875 (2017)

Article  CAS  PubMed  PubMed Central  Google Scholar 

A. GhelliLuserna di Rora, C. Cerchione, G. Martinelli, G. Simonetti, A WEE1 family business: regulation of mitosis, cancer progression, and therapeutic target. J. Hematol. Oncol. 13, 126 (2020)

Article  Google Scholar 

M. Schmidt, A. Rohe, C. Platzer, A. Najjar, F. Erdmann, W. Sippl, Regulation of G2/M Transition by Inhibition of WEE1 and PKMYT1 Kinases. Molecules. 22, 2045 (2017)

A. Fattaey, R.N. Booher, Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14. Prog. Cell Cycle Res. 3, 233–240 (1997)

Article  CAS  PubMed  Google Scholar 

C.M. Toledo, Y. Ding, P. Hoellerbauer, R.J. Davis, R. Basom, E.J. Girard, E. Lee, P. Corrin, T. Hart, H. Bolouri, J. Davison, Q. Zhang, J. Hardcastle, B.J. Aronow, C.L. Plaisier, N.S. Baliga, J. Moffat, Q. Lin, X.N. Li, D.H. Nam, J. Lee, S.M. Pollard, J. Zhu, J.J. Delrow, B.E. Clurman, J.M. Olson, P.J. Paddison, Genome-wide CRISPR-Cas9 screens reveal loss of redundancy between PKMYT1 and WEE1 in Glioblastoma stem-like cells. Cell Rep. 13, 2425–2439 (2015)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Z.H. Xuan, H.P. Wang, X.N. Zhang, Z.X. Chen, H.Y. Zhang, M.M. Gu, PKMYT1 aggravates the progression of ovarian cancer by targeting SIRT3. Eur. Rev. Med. Pharmacol. Sci. 24, 5259–5266 (2020)

PubMed  Google Scholar 

J. Wang, L. Wang, S. Chen, H. Peng, L. Xiao, E. Du, Y. Liu, D. Lin, Y. Wang, Y. Xu, K. Yang, PKMYT1 is associated with prostate cancer malignancy and may serve as a therapeutic target. Gene 744, 144608 (2020)

Article  CAS  PubMed  Google Scholar 

Q. Zhang, X. Zhao, C. Zhang, W. Wang, F. Li, D. Liu, K. Wu, D. Zhu, S. Liu, C. Shen, X. Yuan, K. Zhang, Y. Yang, Y. Zhang, S. Zhao, Overexpressed PKMYT1 promotes tumor progression and associates with poor survival in esophageal squamous cell carcinoma. Cancer Manag. Res. 11, 7813–7824 (2019)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J. Chen, X. Hua, H. Chen, X. Qiu, H. Xiao, S. Ge, C. Liang, Q. Zhou, PKMYT1, exacerbating the progression of clear cell renal cell carcinoma, is implied as a biomarker for the diagnosis and prognosis. Aging (Albany NY) 13, 25778–25798 (2021)

Article  CAS  Google Scholar 

C.R.M. Asquith, T. Laitinen, M.P. East, PKMYT1: a forgotten member of the WEE1 family. Nat. Rev. Drug Discov. 19, 157 (2020)

Article  CAS  PubMed  Google Scholar 

Y. Liu, J. Qi, Z. Dou, J. Hu, L. Lu, H. Dai, H. Wang, W. Yang, Systematic expression analysis of WEE family kinases reveals the importance of PKMYT1 in breast carcinogenesis. Cell Prolif. 53, e12741 (2020)

Article  PubMed  Google Scholar 

H. Nakajima, F. Toyoshima-Morimoto, E. Taniguchi, E. Nishida, Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate. J. Biol. Chem. 278, 25277–25280 (2003)

Article  CAS  PubMed  Google Scholar 

Y. Hu, C. Gong, Z. Li, J. Liu, Y. Chen, Y. Huang, Q. Luo, S. Wang, Y. Hou, S. Yang, Y. Xiao, Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification. Mol Cancer. 21, 34 (2022)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Y. He, X. Jiang, L. Duan, Q. Xiong, Y. Yuan, P. Liu, L. Jiang, Q. Shen, S. Zhao, C. Yang, Y. Chen, LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway. Mol. Cancer. 20, 156 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

C.W. Lewis, A.B. Bukhari, E.J. Xiao, W.S. Choi, J.D. Smith, E. Homola, J.R. Mackey, S.D. Campbell, A.M. Gamper, G.K. Chan, Upregulation of Myt1 promotes acquired resistance of cancer cells to Wee1 inhibition. Cancer Res. 79, 5971–5985 (2019)

Article  CAS  PubMed  Google Scholar 

L. Liu, J. Wu, S. Wang, X. Luo, Y. Du, D. Huang, D. Gu, F. Zhang, PKMYT1 promoted the growth and motility of hepatocellular carcinoma cells by activating beta-catenin/TCF signaling. Exp. Cell Res. 358, 209–216 (2017)

Article  CAS  PubMed  Google Scholar 

J. Cai, H. Guan, L. Fang, Y. Yang, X. Zhu, J. Yuan, J. Wu, M. Li, MicroRNA-374a activates Wnt/beta-catenin signaling to promote breast cancer metastasis. J. Clin. Invest. 123, 566–579 (2013)

CAS  PubMed  PubMed Central  Google Scholar 

J. Cai, R. Li, X. Xu, L. Zhang, R. Lian, L. Fang, Y. Huang, X. Feng, X. Liu, X. Li, X. Zhu, H. Zhang, J. Wu, M. Zeng, E. Song, Y. He, Y. Yin, J. Li, M. Li, CK1alpha suppresses lung tumour growth by stabilizing PTEN and inducing autophagy. Nat. Cell Biol. 20, 465–478 (2018)

Article  CAS  PubMed  Google Scholar 

P. Yuan, L. Dong, Q. Cheng, S. Wang, Z. Li, Y. Sun, S. Han, J. Yin, B. Peng, X. He, W. Liu, Prototype foamy virus elicits complete autophagy involving the ER stress-related UPR pathway. Retrovirology 14, 16 (2017)

Article  PubMed  PubMed Central  Google Scholar 

H.T. Ma, R.Y. Poon, Synchronization of HeLa cells. Methods Mol. Biol. 1524, 189–201 (2017)

Article  CAS  PubMed  Google Scholar 

J.P. Chow, R.Y. Poon, H.T. Ma, Inhibitory phosphorylation of cyclin-dependent kinase 1 as a compensatory mechanism for mitosis exit. Mol. Cell Biol. 31, 1478–1491 (2011)

Article  CAS  PubMed  PubMed Central  Google Scholar 

D. Gallo, J.T.F. Young, J. Fourtounis, G. Martino, A. Alvarez-Quilon, C. Bernier, N.M. Duffy, R. Papp, A. Roulston, R. Stocco, J. Szychowski, A. Veloso, H. Alam, P.S. Baruah, A.B. Fortin, J. Bowlan, N. Chaudhary, J. Desjardins, E. Dietrich, S. Fournier, C. Fugere-Desjardins, T. Goullet de Rugy, M.E. Leclaire, B. Liu, V. Bhaskaran, Y. Mamane, H. Melo, O. Nicolas, A. Singhania, R.K. Szilard, J. Tkac, S.Y. Yin, S.J. Morris, M. Zinda, C.G. Marshall, D. Durocher, CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition. Nature 604, 749–756 (2022)

Article  CAS