Baptiste CG, Battista M-C, Trottier A, Baillargeon J-P. Insulin and hyperandrogenism in women with polycystic ovary syndrome. J Steroid Biochem Mol Biol. 2010;122(1–3):42–52.

Article  CAS  PubMed  Google Scholar 

Xing C, Zhang J, Zhao H, He B. Effect of sex hormone-binding globulin on polycystic ovary syndrome: mechanisms, manifestations, genetics, and treatment. Int J Women’s Health. 2022;14:91–105.

Article  CAS  Google Scholar 

Emami N, Moini A, Yaghmaei P, Akbarinejad V, Shahhoseini M, Alizadeh AR. Differences in expression of genes related to steroidgenesis in abdominal subcutaneous adipose tissue of pregnant women with and without PCOS; a case control study. BMC Pregnancy Childbirth. 2021;21(1):490.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumari S, Chaurasiya V, Onteru SK, Singh D. Regulation of granulosa cell functions through NRP-1 mediated internalization of follicular fluid non-exosomal miR-210. Cell Tissue Res. 2021;386(3):649–60.

Article  CAS  PubMed  Google Scholar 

Colella M, Cuomo D, Peluso T, Falanga I, Mallardo M, De Felice M, Ambrosino C. Ovarian aging: role of pituitary-ovarian axis hormones and ncRNAs in regulating ovarian mitochondrial activity. Front Endocrinol. 2021;12:791071.

Article  Google Scholar 

Escobar-Morreale HF. Polycystic ovary syndrome: Definition, aetiology, diagnosis and treatment. Nat Rev Endocrinol. 2018;14(5):270–84.

Article  PubMed  Google Scholar 

AziziKutenaei M, Hosseini Teshnizi S, Ghaemmaghami P, Eini F, Roozbeh N. The effects of myo-inositol vs metformin on the ovarian function in the polycystic ovary syndrome: a systematic review and meta-analysis. Eur Rev Med Pharmacol Sci. 2021;25(7):3105–15.

CAS  Google Scholar 

Kunitomi C, Harada M, Kusamoto A, Azhary JM, Nose E, Koike H, Xu Z, Urata Y, Takahashi N, Wada-Hiraike O, et al. Induction of aryl hydrocarbon receptor in granulosa cells by endoplasmic reticulum stress contributes to pathology of polycystic ovary syndrome. Mol Hum Reprod. 2021;27(3):gaab003.

Article  PubMed  Google Scholar 

Montazeri-Najafabady N, Chatrabnous N, Arabnezhad MR, Azarpira N. Anti-androgenic effect of astaxanthin in LNCaP cells is mediated through the aryl hydrocarbon-androgen receptors cross talk. J Food Biochem. 2021;45(4):e13702.

Article  CAS  PubMed  Google Scholar 

Bajard L, Negi CK, Mustieles V, Melymuk L, Jomini S, Barthelemy-Berneron J, Fernandez MF, Blaha L. Endocrine disrupting potential of replacement flame retardants – Review of current knowledge for nuclear receptors associated with reproductive outcomes. Environ Int. 2021;153:106550.

Article  CAS  PubMed  Google Scholar 

Pocar P, Fischer B, Klonisch T, Hombach-Klonisch S. Molecular interactions of the aryl hydrocarbon receptor and its biological and toxicological relevance for reproduction. Reproduction. 2005;129(4):379–89.

Article  CAS  PubMed  Google Scholar 

Swedenborg E, Rüegg J, Mäkelä S, Pongratz I. Endocrine disruptive chemicals: Mechanisms of action and involvement in metabolic disorders. J Mol Endocrinol. 2009;43(1):1–10.

Article  CAS  PubMed  Google Scholar 

Baba T, Mimura J, Nakamura N, Harada N, Yamamoto M, Morohashi K-I, Fujii-Kuriyama Y. Intrinsic function of the aryl hydrocarbon (dioxin) receptor as a key factor in female reproduction. Mol Cell Biol. 2005;25(22):10040–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harper PA, Riddick DS, Okey AB. Regulating the regulator: Factors that control levels and activity of the aryl hydrocarbon receptor. Biochem Pharmacol. 2006;72(3):267–79.

Article  CAS  PubMed  Google Scholar 

Larigot L, Juricek L, Dairou J, Coumoul X. AhR signaling pathways and regulatory functions. Biochimie Open. 2018;7:1–9.

Article  PubMed  PubMed Central  Google Scholar 

Wu Y, Baumgarten SC, Zhou P, Stocco C. Testosterone-dependent interaction between androgen receptor and aryl hydrocarbon receptor induces liver receptor homolog 1 expression in rat granulosa cells. Mol Cell Biol. 2013;33(15):2817–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JJ, Chae SJ, Choi YM, Hwang SS, Hwang KR, Kim SM, Yoon SH, Moon SY. Assessment of hirsutism among Korean women: Results of a randomly selected sample of women seeking pre-employment physical check-up. Hum Reprod. 2011;26(1):214–20.

Article  PubMed  Google Scholar 

Chung YK, Kim JJ, Hong MA, Hwang KR, Chae SJ, Yoon SH, Choi YM. Association between polycystic ovary syndrome and the polymorphisms of aryl hydrocarbon receptor repressor, glutathione-S-transferase T1, and glutathione-S-transferase M1 genes. Gynecol Endocrinol. 2021;37(6):558–61.

Article  CAS  PubMed  Google Scholar 

Mohammadi S, Eini F, Bazarganipour F, Taghavi SA, Kutenaee MA. The effect of Myo-inositol on fertility rates in poor ovarian responder in women undergoing assisted reproductive technique: a randomized clinical trial. Reprod Biol Endocrinol. 2021;19(1):1–7.

Article  Google Scholar 

Diaz F, O’brien M, Wigglesworth K, Eppig J. The preantral granulosa cell to cumulus cell transition in the mouse ovary: development of competence to undergo expansion. Dev Biol. 2006;299(1):91–104.

Article  CAS  PubMed  Google Scholar 

Scott L, Alvero R, Leondires M, Miller B. The morphology of human pronuclear embryos is positively related to blastocyst development and implantation. Hum Reprod. 2000;15(11):2394–403.

Article  CAS  PubMed  Google Scholar 

Depa-Martynow M, Jedrzejczak P, Pawelczyk L. Pronuclear scoring as a predictor of embryo quality in in vitro fertilization program. Folia histochemica et cytobiologica. 2007;45(1):85–9.

Google Scholar 

Li A, Zhang L, Jiang J, Yang N, Liu Y, Cai L, Cui Y, Diao F, Han X, Liu J. Follicular hyperandrogenism and insulin resistance in polycystic ovary syndrome patients with normal circulating testosterone levels. J Biomed Res. 2018;32(3):208.

Article  CAS  PubMed Central  Google Scholar 

Eini F, Novin MG, Joharchi K, Hosseini A, Nazarian H, Piryaei A, Bidadkosh A. Intracytoplasmic oxidative stress reverses epigenetic modifications in polycystic ovary syndrome. Reprod Fertil Dev. 2017;29(12):2313–23.

Article  CAS  PubMed  Google Scholar 

Eini F, Bidadkosh A, Nazarian H, Piryaei A, Ghaffari Novin M, Joharchi K. Thymoquinone reduces intracytoplasmic oxidative stress and improves epigenetic modification in polycystic ovary syndrome mice oocytes, during in-vitro maturation. Mol Reprod Dev. 2019;86(8):1053–66.

Article  CAS  PubMed  Google Scholar 

Jafarzadeh H, Nazarian H, Ghaffari Novin M, Shams Mofarahe Z, Eini F, Piryaei A. Improvement of oocyte in vitro maturation from mice with polycystic ovary syndrome by human mesenchymal stromal cell–conditioned media. J Cell Biochem. 2018;119(12):10365–75.

Article  CAS  PubMed  Google Scholar 

Shirzeyli MH, Amidi F, Shamsara M, Nazarian H, Eini F, Shirzeyli FH, Zolbin MM, Novin MG, Joupari MD. Exposing mouse oocytes to mitoq during in vitro maturation improves maturation and developmental competence. Iran J Biotechnol. 2020;18(3):12–21.

Google Scholar 

Li J, Chen H, Gou M, Tian C, Wang H, Song X, Keefe DL, Bai X, Liu L. Molecular features of polycystic ovary syndrome revealed by transcriptome analysis of oocytes and cumulus cells. Front Cell Dev Biol. 2021;9:735684–735684.

Article  PubMed  PubMed Central  Google Scholar 

Matvere A, Teino I, Varik I, Kuuse S, Tiido T, Kristjuhan A, Maimets T. Fsh/lh-dependent upregulation of ahr in murine granulosa cells is controlled by pka signaling and involves epigenetic regulation. Int J Mol Sci. 2019;20(12):3068.

Article  CAS  PubMed Central  Google Scholar 

Chapkin RS, Davidson LA, Park H, Jin UH, Fan YY, Cheng Y, Hensel ME, Landrock KK, Allred C, Menon R. Role of the Aryl Hydrocarbon Receptor (AhR) in mediating the effects of coffee in the colon. Mol Nutr Food Res. 2021;65(20):2100539.

Article  CAS  Google Scholar 

Murray IA, Patterson AD, Perdew GH. Aryl hydrocarbon receptor ligands in cancer: Friend and foe. Nat Rev Cancer. 2014;14(12):801–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bock KW. Aryl hydrocarbon receptor (AHR) functions: Balancing opposing processes including inflammatory reactions. Biochem Pharmacol. 2020;178:114093.

Article  CAS  PubMed  Google Scholar 

Shivanna B, Chu C, Moorthy B. The Aryl Hydrocarbon Receptor (AHR): a novel therapeutic target for pulmonary diseases? Int J Mol Sci. 2022;23(3):1516.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosenfield RL, Ehrmann DA. The Pathogenesis of Polycystic Ovary Syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited. Endocr Rev. 2016;37(5):467–520.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hayes CL, Spink DC, Spink BC, Cao JQ, Walker NJ, Sutter TR. 17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc Natl Acad Sci U S A. 1996;93(18):9776–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsuchiya Y, Nakajima M, Yokoi T. Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005;227(2):115–24.

Article  CAS  PubMed