Design, synthesis and anti-diabetic activity of piperazine sulphonamide derivatives as dipeptidyl peptidase-4 inhibitors

Article title

Abstract

Keywords

1. Introduction

2. Experimental procedure

3. In vitro assay for the inhibition of dipeptidyl peptidase-4 (DPP-4)

4. In-vivo anti-diabetic studies

4.1. Acute toxicity study

4.2. An oral glucose tolerance test (OGTT)

4.3. In-vivo study of antihyperglycemic activity in a STZ-induced T2DM model

4.4. Statistical analysis

5. Results and discussion

5.1. Molecular docking

5.2. Chemistry

5.3. In vitro DPP-4 assay and structure-activity relationship studies

5.4. In-vivo study of antihyperglycemic activity in a STZ-induced T2DM model

5.5. Oral glucose tolerance test in rats and the response of test substances on blood sugar levels

6. Conclusion

Acknowledgments

References

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