Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.

Article  PubMed  Google Scholar 

Keaver L, Xu B, Jaccard A, Webber L. Morbid obesity in the UK: a modelling projection study to 2035. Scand J Public Health. 2020;48:422–7.

Article  PubMed  Google Scholar 

Crosbie EJ, Zwahlen M, Kitchener HC, Egger M, Renehan AG. Body mass index, hormone replacement therapy, and endometrial cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2010;19:3119–30.

Article  CAS  PubMed  Google Scholar 

Weihe P, Spielmann J, Kielstein H, Henning-Klusmann J, Weihrauch-Blüher S. Childhood obesity and cancer risk in adulthood. Curr Obes Rep. 2020;9:204–12.

Article  PubMed  Google Scholar 

Aarestrup J, Gamborg M, Ulrich LG, Sørensen TIA, Baker JL. Childhood body mass index and height and risk of histologic subtypes of endometrial cancer. Int J Obes. 2016;40:1096–102.

Article  CAS  Google Scholar 

von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61:344–9.

Article  Google Scholar 

Smith GD, Ebrahim S. ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? Int. J. Epidemiol. 2003;32:1–22.

Article  PubMed  Google Scholar 

Burgess S, Thompson SG. Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects. Am J Epidemiol. 2015;181:251–60.

Article  PubMed  PubMed Central  Google Scholar 

Richardson TG, Sanderson E, Elsworth B, Tilling K, Davey Smith G. Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study. BMJ. 2020;369:m1203.

Article  PubMed  PubMed Central  Google Scholar 

O’Mara TA, Glubb DM, Amant F, Annibali D, Ashton K, Attia J, et al. Identification of nine new susceptibility loci for endometrial cancer. Nat Commun. 2018;9:3166.

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44:512–25.

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Davey, Smith G, Haycock PC, Burgess S. Consistent estimation in Mendelian randomization with Some invalid instruments using a weighted median estimator. Genet Epidemiol. 2016;40:304–14.

Article  PubMed  PubMed Central  Google Scholar 

Hartwig FP, Davey Smith G, Bowden J. Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption. Int J Epidemiol. 2017;46:1985–98.

Article  PubMed  PubMed Central  Google Scholar 

Hemani G, Bowden J, Davey Smith G. Evaluating the potential role of pleiotropy in Mendelian randomization studies. Hum Mol Genet. 2018;27:R195–R208.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, et al. The MR-Base platform supports systematic causal inference across the human phenome. Elife. 2018;7:e34408 https://doi.org/10.7554/eLife.34408

Article  PubMed  PubMed Central  Google Scholar 

Yavorska OO, Burgess S. MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data. Int J Epidemiol. 2017;46:1734–9.

Article  PubMed  PubMed Central  Google Scholar 

Viechtbauer W. Conducting meta-analyses in R with the metafor package. J Stat Softw. 2010;36:1–48.

Article  Google Scholar 

Burgess S, Davies NM, Thompson SG. Bias due to participant overlap in two-sample Mendelian randomization. Genet Epidemiol. 2016;40:597–608.

Article  PubMed  PubMed Central  Google Scholar 

Mahdy H, Casey MJ, Crotzer D. Endometrial cancer. StatPearls. Treasure Island (FL): StatPearls Publishing; 2021. https://www.ncbi.nlm.nih.gov/books/NBK525981/.

Ogden CL, Carroll MD, Curtin LR, Lamb MM, Flegal KM. Prevalence of high body mass index in US children and adolescents, 2007–2008. JAMA. 2010;303:242–9.

Article  CAS  PubMed  Google Scholar 

Jaishuen A, Kunakornporamat K, Viriyapak B, Benjapibal M, Chaopotong P, Petsuksiri J, et al. Incidence and clinical outcomes of non-endometrioid carcinoma of endometrium: Siriraj Hospital experience. Asian Pac J Cancer Prev. 2014;15:2905–9.

Article  PubMed  Google Scholar 

Painter JN, O’Mara TA, Marquart L, Webb PM, Attia J, Medland SE, et al. Genetic risk score Mendelian randomization shows that obesity measured as body mass index, but not waist:hip ratio, is causal for endometrial cancer. Cancer Epidemiol Biomarkers Prev. 2016;25:1503–10.

Article  PubMed  PubMed Central  Google Scholar 

Kaaks R, Lukanova A, Kurzer MS. Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomarkers Prev. 2002;11:1531–43.

CAS  PubMed  Google Scholar 

Mesa Valencia DC, Mericq V, Corvalán C, Pereira A. Obesity and related metabolic biomarkers and its association with serum levels of estrogen in pre-pubertal Chilean girls. Endocr Res. 2020;45:102–10.

Article  CAS  PubMed  Google Scholar 

Tobin LM, Mavinkurve M, Carolan E, Kinlen D, O’Brien EC, Little MA, et al. NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient. JCI insight. 2017;2. https://doi.org/10.1172/jci.insight.94939.