Elevation of spermine remodels immunosuppressive microenvironment through driving the modification of PD-L1 in hepatocellular carcinoma

Novita Sari I, Setiawan T, Seock Kim K, Toni Wijaya Y, Won Cho K, Young Kwon H. Metabolism and function of polyamines in cancer progression. Cancer Lett. 2021;519:91–104.

CAS  PubMed  Google Scholar 

Igarashi K, Kashiwagi K. The functional role of polyamines in eukaryotic cells. Int J Biochem Cell Biol. 2019;107:104–15.

CAS  PubMed  Google Scholar 

Sagar NA, Tarafdar S, Agarwal S, Tarafdar A, Sharma S. Polyamines: functions, metabolism, and role in human disease management. Med Sci (Basel). 2021;9(2):44.

CAS  Google Scholar 

Casero RA Jr, Murray Stewart T, Pegg AE. Polyamine metabolism and cancer: treatments, challenges and opportunities. Nat Rev Cancer. 2018;18(11):681–95.

CAS  PubMed  PubMed Central  Google Scholar 

Guo Y, Ye Q, Deng P, Cao Y, He D, Zhou Z, Wang C, Zaytseva YY, Schwartz CE, Lee EY, et al. Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression. Nat Commun. 2020;11(1):3243.

CAS  PubMed  PubMed Central  Google Scholar 

Casero RA Jr, Marton LJ. Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat Rev Drug Discov. 2007;6(5):373–90.

CAS  PubMed  Google Scholar 

Liu R, Bi K, Jia Y, Wang Q, Yin R, Li Q. Determination of polyamines in human plasma by high-performance liquid chromatography coupled with Q-TOF mass spectrometry. J Mass Spectrom. 2012;47(10):1341–6.

CAS  PubMed  Google Scholar 

Byun JA, Lee SH, Jung BH, Choi MH, Moon MH, Chung BC. Analysis of polyamines as carbamoyl derivatives in urine and serum by liquid chromatography-tandem mass spectrometry. Biomed Chromatogr. 2008;22(1):73–80.

CAS  PubMed  Google Scholar 

Sen U, Guha S. The role of polyamines as a marker of tumor progression and regression in experimental tumors. Neoplasma. 1990;37(5):521–6.

CAS  PubMed  Google Scholar 

Minois N, Carmona-Gutierrez D, Madeo F. Polyamines in aging and disease. Aging (Albany NY). 2011;3(8):716–32.

Google Scholar 

Nakajima KI, Zhu K, Sun YH, Hegyi B, Zeng Q, Murphy CJ, Small JV, Chen-Izu Y, Izumiya Y, Penninger JM, et al. KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nat Commun. 2015;6:8532.

CAS  PubMed  Google Scholar 

Murray-Stewart TR, Woster PM, Casero RA Jr. Targeting polyamine metabolism for cancer therapy and prevention. Biochem J. 2016;473(19):2937–53.

CAS  PubMed  Google Scholar 

Dai F, Li Q, Wang Y, Ge C, Feng C, Xie S, He H, Xu X, Wang C. Design, synthesis, and biological evaluation of mitochondria-targeted flavone-naphthalimide-polyamine conjugates with antimetastatic activity. J Med Chem. 2017;60(5):2071–83.

CAS  PubMed  Google Scholar 

Mandal S, Mandal A, Park MH. Depletion of the polyamines spermidine and spermine by overexpression of spermidine/spermine N(1)-acetyltransferase 1 (SAT1) leads to mitochondria-mediated apoptosis in mammalian cells. Biochem J. 2015;468(3):435–47.

CAS  PubMed  Google Scholar 

Kakimoto M, Yamamoto H, Tanaka AR. Spermine synthesis inhibitor blocks 25-hydroxycholesterol-induced- apoptosis via SREBP2 upregulation in DLD-1 cell spheroids. Biochem Biophys Rep. 2020;22:100754.

PubMed  PubMed Central  Google Scholar 

Puleston DJ, Baixauli F, Sanin DE, Edwards-Hicks J, Villa M, Kabat AM, Kaminski MM, Stanckzak M, Weiss HJ, Grzes KM, et al. Polyamine metabolism is a central determinant of helper T cell lineage fidelity. Cell. 2021;184(16):4186-4202.e4120.

CAS  PubMed  PubMed Central  Google Scholar 

McNamara KM, Gobert AP, Wilson KT. The role of polyamines in gastric cancer. Oncogene. 2021;40(26):4399–412.

CAS  PubMed  PubMed Central  Google Scholar 

Hesterberg RS, Cleveland JL, Epling-Burnette PK. Role of polyamines in immune cell functions. Med Sci (Basel). 2018;6(1):22.

Google Scholar 

Zhou S, Gu J, Liu R, Wei S, Wang Q, Shen H, Dai Y, Zhou H, Zhang F, Lu L. Spermine alleviates acute liver injury by inhibiting liver-resident macrophage pro-inflammatory response through ATG5-dependent autophagy. Front Immunol. 2018;9:948.

PubMed  PubMed Central  Google Scholar 

Kano Y, Soda K, Nakamura T, Saitoh M, Kawakami M, Konishi F. Increased blood spermine levels decrease the cytotoxic activity of lymphokine-activated killer cells: a novel mechanism of cancer evasion. Cancer Immunol Immunother. 2007;56(6):771–81.

CAS  PubMed  Google Scholar 

Evans CH, Lee TS, Flugelman AA. Spermine-directed immunosuppression of cervical carcinoma cell sensitivity to a majority of lymphokine-activated killer lymphocyte cytotoxicity. Nat Immun. 1995;14(3):157–63.

CAS  PubMed  Google Scholar 

Zhang H, Zhang W, Jiang L, Chen Y. Recent advances in systemic therapy for hepatocellular carcinoma. Biomark Res. 2022;10(1):3.

CAS  PubMed  PubMed Central  Google Scholar 

Zongyi Y, Xiaowu L. Immunotherapy for hepatocellular carcinoma. Cancer Lett. 2020;470:8–17.

PubMed  Google Scholar 

Liu Z, Liu X, Liang J, Liu Y, Hou X, Zhang M, Li Y, Jiang X. Immunotherapy for hepatocellular carcinoma: current status and future prospects. Front Immunol. 2021;12:765101.

CAS  PubMed  PubMed Central  Google Scholar 

Al-Malki AL, Razvi SS, Mohammed FA, Zamzami MA, Choudhry H, Kumosani TA, Balamash KS, Alshubaily FA, Abualnaja KO, et al. Synthesis and in vitro antitumor activity of novel acylspermidine derivative N-(4-aminobutyl)-N-(3-aminopropyl)-8-hydroxy-dodecanamide (AAHD) against HepG2 cells. Bioorg Chem. 2019;88:102937.

CAS  PubMed  Google Scholar 

Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV. The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases. Nat Rev Endocrinol. 2018;15(1):33–51.

PubMed  PubMed Central  Google Scholar 

Canaff L, Petit JL, Kisiel M, Watson PH, Gascon-Barre M, Hendy GN. Extracellular calcium-sensing receptor is expressed in rat hepatocytes coupling to intracellular calcium mobilization and stimulation of bile flow. J Biol Chem. 2001;276(6):4070–9.

CAS  PubMed  Google Scholar 

Wang Y, Wang Y, Li F, Zhang X, Li H, Yang G, Xu C, Wei C. Spermine protects cardiomyocytes from high glucose-induced energy disturbance by targeting the CaSR-gp78-ubiquitin proteasome system. Cardiovasc Drugs Ther. 2021;35(1):73–85.

CAS  PubMed  Google Scholar 

Hu F, Pan L, Zhang K, Xing F, Wang X, Lee I, Zhang X, Xu J. Elevation of extracellular Ca2+ induces store-operated calcium entry via calcium-sensing receptors: a pathway contributes to the proliferation of osteoblasts. PLoS ONE. 2014;9(9):e107217.

PubMed  PubMed Central  Google Scholar 

Xie R, Xu J, Xiao Y, Wu J, Wan H, Tang B, Liu J, Fan Y, Wang S, Wu Y, et al. Calcium promotes human gastric cancer via a novel coupling of calcium-sensing receptor and TRPV4 channel. Cancer Res. 2017;77(23):6499–512.

CAS  PubMed  Google Scholar 

Du L, Lee JH, Jiang H, Wang C, Wang S, Zheng Z, Shao F, Xu D, Xia Y, Li J, et al. beta-Catenin induces transcriptional expression of PD-L1 to promote glioblastoma immune evasion. J Exp Med. 2020;217(11):1.

CAS  Google Scholar 

Hsu JM, Xia W, Hsu YH, Chan LC, Yu WH, Cha JH, Chen CT, Liao HW, Kuo CW, Khoo KH, et al. STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion. Nat Commun. 2018;9(1):1908.

PubMed  PubMed Central  Google Scholar 

Wang C, Jia Q, Sun C, Jing C. Calcium sensing receptor contribute to early brain injury through the CaMKII/NLRP3 pathway after subarachnoid hemorrhage in mice. Biochem Biophys Res Commun. 2020;530(4):651–7.

CAS  PubMed  Google Scholar 

Yamamura A, Guo Q, Yamamura H, Zimnicka AM, Pohl NM, Smith KA, Fernandez RA, Zeifman A, Makino A, Dong H, et al. Enhanced Ca(2+)-sensing receptor function in idiopathic pulmonary arterial hypertension. Circ Res. 2012;111(4):469–81.

CAS  PubMed  PubMed Central  Google Scholar 

Tennakoon S, Aggarwal A, Kallay E. The calcium-sensing receptor and the hallmarks of cancer. Biochim Biophys Acta. 2016;1863:1398–407.

CAS  PubMed  Google Scholar 

Meng K, Xu J, Zhang C, Zhang R, Yang H, Liao C, Jiao J. Calcium sensing receptor modulates extracellular calcium entry and proliferation via TRPC3/6 channels in cultured human mesangial cells. PLoS ONE. 2014;9(6):e98777.

PubMed  PubMed Central  Google Scholar 

Owen JL, Cheng SX, Ge Y, Sahay B, Mohamadzadeh M. The role of the calcium-sensing receptor in gastrointestinal inflammation. Semin Cell Dev Biol. 2016;49:44–51.

CAS  PubMed  Google Scholar 

Giudice ML, Mihalik B, Dinnyes A, Kobolak J. The nervous system relevance of the calcium sensing receptor in health and disease. Molecules. 2019;24(14):2546.

PubMed Central  Google Scholar 

Maltsev AV. Agmatine modulates calcium handling in cardiomyocytes of hibernating ground squirrels through calcium-sensing receptor signaling. Cell Signal. 2018;51:1–12.

CAS  PubMed  Google Scholar 

Brennan SC, Thiem U, Roth S, Aggarwal A, Fetahu I, Tennakoon S, Gomes AR, Brandi ML, Bruggeman F, Mentaverri R, et al. Calcium sensing receptor signalling in physiology and cancer. Biochim Biophys Acta. 2013;1833(7):1732–44.

CAS  PubMed  Google Scholar 

Tuffour A, Kosiba AA, Zhang Y, Peprah FA, Gu J, Shi H. Role of the calcium-sensing receptor (CaSR) in cancer metastasis to bone: Identifying a potential therapeutic target. Biochim Biophys Acta Rev Cancer. 2021;1875(2):188528.

CAS  PubMed  Google Scholar 

Hernandez-Bedolla MA, Gonzalez-Dominguez E, Zavala-Barrera C, Gutierrez-Lopez TY, Hidalgo-Moyle JJ, Vazquez-Prado J, Sanchez-Torres C, Reyes-Cruz G. Calcium-sensing-receptor (CaSR) controls IL-6 secretion in metastatic breast cancer MDA-MB-231 cells by a dual mechanism revealed by agonist and inverse-agonist modulators. Mol Cell Endocrinol. 2016;436:159–68.

CAS  PubMed 

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