Allan KC, Hu LR, Scavuzzo MA, Morton AR, Gevorgyan AS, Cohn EF, Clayton BLL, Bederman IR, Hung S, Bartels CF, Madhavan M, Tesar PJ (2021) Non-canonical targets of hif1a impair oligodendrocyte progenitor cell function. Cell Stem Cell 28(2):257-272.e211. https://doi.org/10.1016/j.stem.2020.09.019

Article  CAS  PubMed  Google Scholar 

Back SA, Rosenberg PA (2014) Pathophysiology of glia in perinatal white matter injury. Glia 62(11):1790–1815. https://doi.org/10.1002/glia.22658

Article  PubMed  PubMed Central  Google Scholar 

Barateiro A, Brites D, Fernandes A (2016) Oligodendrocyte development and myelination in neurodevelopment: molecular mechanisms in health and disease. Curr Pharm Des 22(6):656–679. https://doi.org/10.2174/1381612822666151204000636

Article  CAS  PubMed  Google Scholar 

Cai J, Tuong CM, Zhang Y, Shields CB, Guo G, Fu H, Gozal D (2012) Mouse intermittent hypoxia mimicking apnoea of prematurity: effects on myelinogenesis and axonal maturation. J Pathol 226(3):495–508. https://doi.org/10.1002/path.2980

Article  CAS  PubMed  Google Scholar 

Chavali M, Ulloa-Navas MJ, Pérez-Borredá P, Garcia-Verdugo JM, McQuillen PS, Huang EJ, Rowitch DH (2020) Wnt-dependent oligodendroglial-endothelial interactions regulate white matter vascularization and attenuate injury. Neuron 108(6):1130-1145.e1135. https://doi.org/10.1016/j.neuron.2020.09.033

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen L, Ren SY, Li RX, Liu K, Chen JF, Yang YJ, Deng YB, Wang HZ, Xiao L, Mei F, Wang F (2021) Chronic exposure to hypoxia inhibits myelinogenesis and causes motor coordination deficits in adult mice. Neurosci Bull. https://doi.org/10.1007/s12264-021-00745-1

Article  PubMed  PubMed Central  Google Scholar 

Cree BAC, Niu J, Hoi KK, Zhao C, Caganap SD, Henry RG, Dao DQ, Zollinger DR, Mei F, Shen YA, Franklin RJM, Ullian EM, Xiao L, Chan JR, Fancy SPJ (2018) Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury. Brain J Neurol 141(1):85–98. https://doi.org/10.1093/brain/awx312

Article  Google Scholar 

Dawson MR, Polito A, Levine JM, Reynolds R (2003) NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS. Mol Cell Neurosci 24(2):476–488. https://doi.org/10.1016/s1044-7431(03)00210-0

Article  CAS  PubMed  Google Scholar 

Dodd JW, Chung AW, van den Broek MD, Barrick TR, Charlton RA, Jones PW (2012) Brain structure and function in chronic obstructive pulmonary disease: a multimodal cranial magnetic resonance imaging study. Am J Respir Crit Care Med 186(3):240–245. https://doi.org/10.1164/rccm.201202-0355OC

Article  PubMed  Google Scholar 

Duncan GJ, Plemel JR, Assinck P, Manesh SB, Muir FGW, Hirata R, Berson M, Liu J, Wegner M, Emery B, Moore GRW, Tetzlaff W (2017) Myelin regulatory factor drives remyelination in multiple sclerosis. Acta Neuropathol 134(3):403–422. https://doi.org/10.1007/s00401-017-1741-7

Article  CAS  PubMed  Google Scholar 

Emery B (2010) Regulation of oligodendrocyte differentiation and myelination. Science (new York, NY) 330(6005):779–782. https://doi.org/10.1126/science.1190927

Article  CAS  Google Scholar 

Fan C, Zhao Y, Yu Q, Yin W, Liu H, Lin J, Yang T, Fan M, Gesang L, Zhang J (2016) Reversible brain abnormalities in people without signs of mountain sickness during high-altitude exposure. Sci Rep 6:33596. https://doi.org/10.1038/srep33596

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gosar D, Tretnjak V, Bregant T, Neubauer D, Derganc M (2020) Reduced white-matter integrity and lower speed of information processing in adolescents with mild and moderate neonatal hypoxic-ischaemic encephalopathy. European J Paediatr Neurol EJPN off j European Paediatr Neurol Soc 28:205–213. https://doi.org/10.1016/j.ejpn.2020.06.003

Article  Google Scholar 

Kirby L, Jin J, Cardona JG, Smith MD, Martin KA, Wang J, Strasburger H, Herbst L, Alexis M, Karnell J, Davidson T, Dutta R, Goverman J, Bergles D, Calabresi PA (2019) Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination. Nat Commun 10(1):3887. https://doi.org/10.1038/s41467-019-11638-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lope-Piedrafita S (2018) Diffusion tensor imaging (DTI). In: García Martín M, López Larrubia P (eds) Preclinical MRI. Methods in Molecular Biology, vol 1718. Humana Press, New York, pp 103–116

Chapter  Google Scholar 

Luks AM (2015) Physiology in medicine: a physiologic approach to prevention and treatment of acute high-altitude illnesses. J Appl Physiol (bethesda) 118(5):509–519. https://doi.org/10.1152/japplphysiol.00955.2014

Article  CAS  Google Scholar 

Macey PM, Kumar R, Woo MA, Valladares EM, Yan-Go FL, Harper RM (2008) Brain structural changes in obstructive sleep apnea. Sleep 31(7):967–977

PubMed  PubMed Central  Google Scholar 

Mao M, Yang L, Jin Z, Li LX, Wang YR, Li TT, Zhao YJ, Ai J (2021) Impact of intrauterine hypoxia on adolescent and adult cognitive function in rat offspring: sexual differences and the effects of spermidine intervention. Acta Pharmacol Sin 42(3):361–369. https://doi.org/10.1038/s41401-020-0437-z

Article  CAS  PubMed  Google Scholar 

Martin D, Windsor J (2008) From mountain to bedside: understanding the clinical relevance of human acclimatisation to high-altitude hypoxia. Postgrad Med j 84(998):622–627. https://doi.org/10.1136/pgmj.2008.068296

Article  CAS  PubMed  Google Scholar 

Miyamoto N, Maki T, Pham LD, Hayakawa K, Seo JH, Mandeville ET, Mandeville JB, Kim KW, Lo EH, Arai K (2013) Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice. Stroke 44(12):3516–3521. https://doi.org/10.1161/strokeaha.113.002813

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mukherjee P, Miller JH, Shimony JS, Philip JV, Nehra D, Snyder AZ, Conturo TE, Neil JJ, McKinstry RC (2002) Diffusion-tensor MR imaging of gray and white matter development during normal human brain maturation. AJNR Am J Neuroradiol 23(9):1445–1456

PubMed  PubMed Central  Google Scholar 

Patwari PP, Carroll MS, Rand CM, Kumar R, Harper R, Weese-Mayer DE (2010) Congenital central hypoventilation syndrome and the PHOX2B gene: a model of respiratory and autonomic dysregulation. Respir Physiol Neurobiol 173(3):322–335. https://doi.org/10.1016/j.resp.2010.06.013

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ravindranath V, Shivakumar BR, Anandatheerthavarada HK (1989) Low glutathione levels in brain regions of aged rats. Neurosci Lett 101(2):187–190. https://doi.org/10.1016/0304-3940(89)90528-4

Article  CAS  PubMed  Google Scholar 

Sampaio-Baptista C, Johansen-Berg H (2017) White matter plasticity in the adult brain. Neuron 96(6):1239–1251. https://doi.org/10.1016/j.neuron.2017.11.026

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sasaki T, Senda M (1999) Evaluation of glutathione localization in brain using 99mTc meso-HMPAO. J Nucl Med off Pub Soc Nucl Medi 40(6):1056–1060

CAS  Google Scholar 

Schwartz ED, Hackney DB (2003) Diffusion-weighted MRI and the evaluation of spinal cord axonal integrity following injury and treatment. Exp Neurol 184(2):570–589. https://doi.org/10.1016/s0014-4886(03)00295-4

Article  PubMed  Google Scholar 

Semenza GL (2012) Hypoxia-inducible factors in physiology and medicine. Cell 148(3):399–408. https://doi.org/10.1016/j.cell.2012.01.021

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stolt CC, Lommes P, Friedrich RP, Wegner M (2004) Transcription factors Sox8 and Sox10 perform non-equivalent roles during oligodendrocyte development despite functional redundancy. Development (cambridge, England) 131(10):2349–2358. https://doi.org/10.1242/dev.01114

Article  CAS  Google Scholar 

Veasey SC, Lear J, Zhu Y, Grinspan JB, Hare DJ, Wang S, Bunch D, Doble PA, Robinson SR (2013) Long-term intermittent hypoxia elevates cobalt levels in the brain and injures white matter in adult mice. Sleep 36(10):1471–1481. https://doi.org/10.5665/sleep.3038

Article  PubMed  PubMed Central  Google Scholar 

Võikar V, Rauvala H, Ikonen E (2002) Cognitive deficit and development of motor impairment in a mouse model of niemann-pick type C disease. Behav Brain Res 132(1):1–10. https://doi.org/10.1016/s0166-4328(01)00380-1

Article  PubMed  Google Scholar 

Wang F, Yang YJ, Yang N, Chen XJ, Huang NX, Zhang J, Wu Y, Liu Z, Gao X, Li T, Pan GQ, Liu SB, Li HL, Fancy SPJ, Xiao L, Chan JR, Mei F (2018) Enhancing oligodendrocyte myelination rescues synaptic loss and improves functional recovery after chronic hypoxia. Neuron 99(4):689-701.e685. https://doi.org/10.1016/j.neuron.2018.07.017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang H, Liu M, Zou G, Wang L, Duan W, He X, Ji M, Zou X, Hu Y, Yang J, Chen G (2021) Deletion of PDK1 in oligodendrocyte lineage cells causes white matter abnormality and myelination defect in the central nervous system. Neurobiol Dis 148:105212. https://doi.org/10.1016/j.nbd.2020.105212

Article  CAS  PubMed  Google Scholar 

Wolfel EE, Selland MA, Mazzeo RS, Reeves JT (1994) Systemic hypertension at 4,300 m is related to sympathoadrenal activity. J Appl Physiol (bethesda) 76(4):1643–1650. https://doi.org/10.1152/jappl.1994.76.4.1643

Article  CAS  Google Scholar 

Xu L, Song H, Qiu Q, Jiang T, Ge P, Su Z, Ma W, Zhang R, Huang C, Li S, Lin D, Zhang J (2021) Different expressions of hif-1α and metabolism in brain and major visceral organs of acute hypoxic mice. Int j Mol Sci. https://doi.org/10.3390/ijms22136705

Article  PubMed  PubMed Central  Google Scholar 

Zhang H, Lin J, Sun Y, Huang Y, Ye H, Wang X, Yang T, Jiang X, Zhang J (2012a) Compromised white matter microstructural integrity after mountain climbing: evidence from diffusion tensor imaging. High Alt Med Biol 13(2):118–125. https://doi.org/10.1089/ham.2011.1073

Article  CAS