In vivo killing of primary HIV-infected cells by peripheral-injected early memory–enriched anti-HIV duoCAR T cells

Research ArticleAIDS/HIVTherapeutics Open Access | 10.1172/jci.insight.161698

Kim Anthony-Gonda,1,2 Alex Ray,3 Hang Su,3 Yuge Wang,2 Ying Xiong,1,2 Danica Lee,3 Ariele Block,3 Vanessa Chilunda,4 Jessica Weiselberg,4 Lily Zemelko,5 Yen Y. Wang,5 Sarah Kleinsorge-Block,6 Jane S. Reese,6 Marcos de Lima,6 Christina Ochsenbauer,7 John C. Kappes,7,8 Dimiter S. Dimitrov,9 Rimas Orentas,1,10 Steven G. Deeks,5 Rachel L. Rutishauser,5 Joan W. Berman,3,4 Harris Goldstein,3,11 and Boro Dropulić1,2

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Anthony-Gonda, K. in: JCI | PubMed | Google Scholar |

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Ray, A. in: JCI | PubMed | Google Scholar

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Su, H. in: JCI | PubMed | Google Scholar |

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Wang, Y. in: JCI | PubMed | Google Scholar

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Xiong, Y. in: JCI | PubMed | Google Scholar |

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Lee, D. in: JCI | PubMed | Google Scholar

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Block, A. in: JCI | PubMed | Google Scholar

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Chilunda, V. in: JCI | PubMed | Google Scholar

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Weiselberg, J. in: JCI | PubMed | Google Scholar |

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Zemelko, L. in: JCI | PubMed | Google Scholar

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Wang, Y. in: JCI | PubMed | Google Scholar

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Kleinsorge-Block, S. in: JCI | PubMed | Google Scholar

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Reese, J. in: JCI | PubMed | Google Scholar |

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by de Lima, M. in: JCI | PubMed | Google Scholar |

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Ochsenbauer, C. in: JCI | PubMed | Google Scholar |

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Kappes, J. in: JCI | PubMed | Google Scholar

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Dimitrov, D. in: JCI | PubMed | Google Scholar

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Orentas, R. in: JCI | PubMed | Google Scholar

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Deeks, S. in: JCI | PubMed | Google Scholar |

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Rutishauser, R. in: JCI | PubMed | Google Scholar

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Berman, J. in: JCI | PubMed | Google Scholar

1Caring Cross, Gaithersburg, Maryland, USA.

2Lentigen, a Miltenyi Biotec Company, Gaithersburg, Maryland, USA.

3Department of Microbiology & Immunology and

4Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

5Department of Medicine, UCSF, San Francisco, California, USA.

6Stem Cell Transplant Program and Center for Regenerative Medicine, University Hospitals Seidman Cancer Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

7Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

8Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, Alabama, USA.

9Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

10Department of Pediatrics, University of Washington School of Medicine, and Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research lnstitute, Seattle, Washington, USA.

11Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA.

Address correspondence to: Kim Anthony-Gonda or Boro Dropulić, 910 Clopper Road, Suite 200-S, Gaithersburg, Maryland 20878, USA. Phone: 240.477.8085; Email: kim.anthony-gonda@caringcross.org (KAG); Email: boro.dropulic@caringcross.org (BD). Or to: Harris Goldstein, 1300 Morris Park Ave, Forchheimer Bld #408, Bronx, New York 10461, USA. Phone: 718.430.2156; Email: harris.goldstein@einsteinmed.edu.

Authorship note: KAG, AR, and HS contributed equally to this work.

Find articles by Goldstein, H. in: JCI | PubMed | Google Scholar |

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