Feigin VL et al (2021) Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol 20:795–820

CAS  Google Scholar 

Lanas F, Seron P (2021) Facing the stroke burden worldwide. Lancet Glob Heal 9:e235–e236

Google Scholar 

Albers GW et al (2018) Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N Engl J Med 378:708–718

PubMed  PubMed Central  Google Scholar 

Berkhemer OA et al (2014) A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med 372:11–20

PubMed  Google Scholar 

Nogueira RG et al (2017) Thrombectomy 6 to 24 hours after stroke with a mismatch between deficit and infarct. N Engl J Med 378:11–21

PubMed  Google Scholar 

Feigin VL, Norrving B, Mensah GA (2017) Global burden of stroke. Circ Res 120:439–448

CAS  PubMed  Google Scholar 

Suarez JI, Tarr RW, Selman WR (2006) Aneurysmal subarachnoid hemorrhage. N Engl J Med 354:387–396

CAS  PubMed  Google Scholar 

Iadecola C, Buckwalter MS, Anrather J (2020) Immune responses to stroke: mechanisms, modulation, and therapeutic potential. J Clin Invest 130:2777–2788

CAS  PubMed  PubMed Central  Google Scholar 

Elkind MSV, Boehme AK, Smith CJ, Meisel A, Buckwalter MS (2020) Infection as a stroke risk factor and determinant of outcome after stroke. Stroke 51:3156–3168

CAS  PubMed  PubMed Central  Google Scholar 

Zheng VZ, Wong GKC (2017) Neuroinflammation responses after subarachnoid hemorrhage: a review. J Clin Neurosci Off J Neurosurg Soc Australas 42:7–11

Google Scholar 

Mracsko E, Veltkamp R (2014) Neuroinflammation after intracerebral hemorrhage. Front Cell Neurosci 8:388

PubMed  PubMed Central  Google Scholar 

Jayaraj RL, Azimullah S, Beiram R, Jalal FY, Rosenberg GA (2019) Neuroinflammation: friend and foe for ischemic stroke. J Neuroinflammation 16:142

PubMed  PubMed Central  Google Scholar 

Shi K et al (2019) Global brain inflammation in stroke. Lancet Neurol 18:1058–1066

PubMed  Google Scholar 

Saand AR, Yu F, Chen J, Chou SH-Y (2019) Systemic inflammation in hemorrhagic strokes — a novel neurological sign and therapeutic target? J Cereb Blood Flow Metab 39:959–988

PubMed  PubMed Central  Google Scholar 

Urra X et al (2009) Monocytes are major players in the prognosis and risk of infection after acute stroke. Stroke. https://doi.org/10.1161/STROKEAHA.108.532085

Article  PubMed  Google Scholar 

Morotti A et al (2017) Lymphopenia, infectious complications, and outcome in spontaneous intracerebral hemorrhage. Neurocrit Care 26:160–166

PubMed  PubMed Central  Google Scholar 

Nam K-W et al (2018) High neutrophil-to-lymphocyte ratio predicts stroke-associated pneumonia. Stroke 49:1886–1892

PubMed  Google Scholar 

Jin R, Liu L, Zhang S, Nanda A, Li G (2013) Role of inflammation and its mediators in acute ischemic stroke. J Cardiovasc Transl Res 6:834–851

PubMed  Google Scholar 

Anrather J, Iadecola C (2016) Inflammation and stroke: an overview. Neurother J Am Soc Exp Neurother 13:661–670

CAS  Google Scholar 

Wang J, Doré S (2007) Inflammation after intracerebral hemorrhage. J Cereb Blood Flow Metab 27:894–908

CAS  PubMed  Google Scholar 

Zhang Z, Fang Y, Lenahan C, Chen S (2021) The role of immune inflammation in aneurysmal subarachnoid hemorrhage. Exp Neurol 336:113535

Google Scholar 

Patel AR, Ritzel R, McCullough LD, Liu F (2013) Microglia and ischemic stroke: a double-edged sword. Int J Physiol Pathophysiol Pharmacol 5:73–90

PubMed  PubMed Central  Google Scholar 

Peeyush Kumar T et al (2019) Endothelial cell dysfunction and injury in subarachnoid hemorrhage. Mol Neurobiol 56:1992–2006

CAS  PubMed  Google Scholar 

Iadecola C, Anrather J (2011) The immunology of stroke: from mechanisms to translation. Nat Med 17:796–808

CAS  PubMed  PubMed Central  Google Scholar 

Stanzione R et al (2022) Role of DAMPs and of leukocytes infiltration in ischemic stroke: insights from animal models and translation to the human disease. Cell Mol Neurobiol 42:545–556

CAS  PubMed  Google Scholar 

Bulters D et al (2018) Haemoglobin scavenging in intracranial bleeding: biology and clinical implications. Nat Rev Neurol 14:416–432

CAS  PubMed  Google Scholar 

Greenhalgh AD et al (2012) Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology. Dis Model Mech 5:823–833

CAS  PubMed  PubMed Central  Google Scholar 

Gidday JM et al (2005) Leukocyte-derived matrix metalloproteinase-9 mediates blood-brain barrier breakdown and is proinflammatory after transient focal cerebral ischemia. Am J Physiol Heart Circ Physiol 289:H558–H568

CAS  PubMed  Google Scholar 

Chu HX et al (2015) Evidence that Ly6Chi monocytes are protective in acute ischemic stroke by promoting M2 macrophage polarization. Stroke 46:1929–1937

CAS  PubMed  Google Scholar 

Keep RF et al (2014) Vascular disruption and blood-brain barrier dysfunction in intracerebral hemorrhage. Fluids Barriers CNS 11:18

PubMed  PubMed Central  Google Scholar 

Huang J, Upadhyay UM, Tamargo RJ (2006) Inflammation in stroke and focal cerebral ischemia. Surg Neurol 66:232–245

PubMed  Google Scholar 

Yilmaz G, Granger DN (2010) Leukocyte recruitment and ischemic brain injury. Neuromol Med 12:193–204

CAS  Google Scholar 

Zhao X et al (2018) Beneficial role of neutrophils through function of Lactoferrin after intracerebral hemorrhage. Stroke 49:1241–1247

CAS  PubMed  PubMed Central  Google Scholar 

Friedrich V et al (2011) Reduction of neutrophil activity decreases early microvascular injury after subarachnoid haemorrhage. J Neuroinflammation 8:103

CAS  PubMed  PubMed Central  Google Scholar 

Otxoa-de-Amezaga A et al (2019) Location of neutrophils in different compartments of the damaged mouse brain after severe ischemia/reperfusion. Stroke 50:1548–1557

CAS  PubMed  Google Scholar 

Perez-de-Puig I et al (2015) Neutrophil recruitment to the brain in mouse and human ischemic stroke. Acta Neuropathol 129:239–257

CAS  PubMed  Google Scholar 

Ritzel RM et al (2015) Functional differences between microglia and monocytes after ischemic stroke. J Neuroinflammation. https://doi.org/10.1186/s12974-015-0329-1

Article  PubMed  PubMed Central  Google Scholar 

Taylor RA, Hammond MD, Ai Y, Sansing LH (2014) CX3CR1 Signaling on monocytes is dispensable after intracerebral hemorrhage. PLoS ONE 9:e114472

PubMed  PubMed Central  Google Scholar 

Xu Z et al (2019) Resident microglia activate before peripheral monocyte infiltration and p75NTR blockade reduces microglial activation and early brain injury after subarachnoid hemorrhage. ACS Chem Neurosci 10:412–423

CAS  PubMed  Google Scholar 

Zhao X et al (2014) Polymorphonuclear neutrophil in brain parenchyma after experimental intracerebral hemorrhage. Transl Stroke Res 5:554–561

PubMed  Google Scholar 

Kim E, Yang J, Beltran CD, Cho S (2014) Role of spleen-derived monocytes/macrophages in acute ischemic brain injury. J Cereb Blood Flow Metab 34:1411–1419

CAS  PubMed  PubMed Central  Google Scholar 

Hammond MD et al (2014) CCR2+ Ly6C(hi) inflammatory monocyte recruitment exacerbates acute disability following intracerebral hemorrhage. J Neurosci 34:3901–3909

PubMed  PubMed Central  Google Scholar 

Wattananit S et al (2016) Monocyte-derived macrophages contribute to spontaneous long-term functional recovery after stroke in mice. J Neurosci 36:4182–4195

CAS  PubMed  PubMed Central  Google Scholar 

Doyle KP et al (2015) B-lymphocyte-mediated delayed cognitive impairment following stroke. J Neurosci 35:2133–2145

CAS  PubMed  PubMed Central  Google Scholar 

Zhou K et al (2017) Regulatory T cells ameliorate intracerebral hemorrhage-induced inflammatory injury by modulating microglia/macrophage polarization through the IL-10/GSK3β/PTEN axis. J Cereb Blood Flow Metab 37:967–979

CAS  PubMed  Google Scholar 

Silver FL, Norris JW, Lewis AJ, Hachinski VC (1984) Early mortality following stroke: a prospective review. Stroke 15:492–496

CAS  PubMed  Google Scholar 

Rymer MM (2011) Hemorrhagic stroke: intracerebral hemorrhage. Mo Med 108:50–54

PubMed  PubMed Central  Google Scholar 

Abulhasan YB, Alabdulraheem N, Simoneau G, Angle MR, Teitelbaum J (2018) Mortality after spontaneous subarachnoid hemorrhage: causality and validation of a prediction model. World Neurosurg 112:e799–e811

PubMed