Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation

Panizo S, Martínez-Arias L, Alonso-Montes C, Cannata P, Martín-Carro B, Fernández-Martín JL, et al. Fibrosis in chronic kidney disease: Pathogenesis and consequences. Int J Mol Sci. 2021;22:408.

CAS  PubMed Central  Google Scholar 

Lin YC, Chang YH, Yang SY, Wu KD, Chu TS. Update of pathophysiology and management of diabetic kidney disease. J Formos Med Assoc. 2018;117:662–75.

CAS  PubMed  Google Scholar 

Ahmad AA, Draves SO, Rosca M. Mitochondria in diabetic kidney disease. Cells. 2021;10:2945.

CAS  PubMed  PubMed Central  Google Scholar 

Boyman L, Karbowski M, Lederer WJ. Regulation of mitochondrial ATP production: Ca2+ signaling and quality control. Trends Mol Med. 2020;26:21–39.

CAS  PubMed  Google Scholar 

Aranda-Rivera AK, Cruz-Gregorio A, Aparicio-Trejo OE, Pedraza-Chaverri  J. Mitochondrial redox signaling and oxidative stress in kidney diseases. Biomolecules. 2021;11:1144.

CAS  PubMed  PubMed Central  Google Scholar 

Duann P, Lin PH. Mitochondria damage and kidney disease. Adv Exp Med Biol. 2017;982:529–51.

CAS  PubMed  PubMed Central  Google Scholar 

Rovira-Llopis S, Bañuls C, Diaz-Morales N, Hernandez-Mijares A, Rocha M, Victor VM. Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications. Redox Biol. 2017;11:637–45.

CAS  PubMed  PubMed Central  Google Scholar 

Jin JY, Wei XX, Zhi XL, Wang XH, Meng D. Drp1-dependent mitochondrial fission in cardiovascular disease. Acta Pharmacol Sin. 2021;42:655–64.

CAS  PubMed  Google Scholar 

Zhang X, Agborbesong E, Li X. The role of mitochondria in acute kidney injury and chronic kidney disease and its therapeutic potential. Int J Mol Sci. 2021;22:11253.

CAS  PubMed  PubMed Central  Google Scholar 

Liu W, Shi LJ, Li SG. The immunomodulatory effect of alpha-lipoic acid in autoimmune diseases. Biomed Res Int. 2019;2019:8086257.

PubMed  PubMed Central  Google Scholar 

Zhao L, Liu Z, Jia H, Feng Z, Liu J, Li X. Lipoamide acts as an indirect antioxidant by simultaneously stimulating mitochondrial biogenesis and phase ii antioxidant enzyme systems in ARPE-19 Cells. PLoS One. 2015;10:e0128502.

PubMed  PubMed Central  Google Scholar 

Li X, Liu Z, Luo C, Jia H, Sun L, Hou B, et al. Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Free Radic Biol Med. 2008;44:1465–74.

CAS  PubMed  PubMed Central  Google Scholar 

Jeoung NH. Pyruvate dehydrogenase kinases: Therapeutic targets for diabetes and cancers. Diabetes Metab J. 2015;39:188–97.

PubMed  PubMed Central  Google Scholar 

Hou Y, Li X, Peng S, Yao J, Bai F, Fang J. Lipoamide ameliorates oxidative stress via induction of Nrf2/ARE signaling pathway in PC12 cells. J Agric Food Chem. 2019;67:8227–34.

CAS  PubMed  Google Scholar 

Zhang Y, Zhou R, Qu Y, Shu M, Guo S, Bai Z. Lipoamide inhibits NF1 deficiency-induced epithelial-mesenchymal transition in murine schwann cells. Arch Med Res. 2017;48:498–505.

CAS  PubMed  Google Scholar 

Strobbe D, Sharma S, Campanella M. Links between mitochondrial retrograde response and mitophagy in pathogenic cell signalling. Cell Mol Life Sci. 2021;78:3767–75.

CAS  PubMed  Google Scholar 

Chae S, Ahn BY, Byun K, Cho YM, Yu MH, Lee B, et al. A systems approach for decoding mitochondrial retrograde signaling pathways. Sci Signal. 2013;6:rs4.

PubMed  Google Scholar 

Ma X, Warnier M, Raynard C, Ferrand M, Kirsh O, Defossez PA, et al. The nuclear receptor RXRA controls cellular senescence by regulating calcium signaling. Aging Cell. 2018;17:e12831.

PubMed  PubMed Central  Google Scholar 

Onuki M, Watanabe M, Ishihara N, Suzuki K, Takizawa K, Hirota M, et al. A partial agonist for retinoid X receptor mitigates experimental colitis. Int Immunol. 2019;31:251–62.

CAS  PubMed  Google Scholar 

Liu H, Yan R, Liang L, Zhang H, Xiang J, Liu L, et al. The role of CDX2 in renal tubular lesions during diabetic kidney disease. Aging. 2021;13:6782–803.

CAS  PubMed  PubMed Central  Google Scholar 

Yu L, Su Y, Paueksakon P, Cheng H, Chen X, Wang H, et al. Integrin α1/Akita double-knockout mice on a Balb/c background develop advanced features of human diabetic nephropathy. Kidney Int. 2012;81:1086–97.

CAS  PubMed  PubMed Central  Google Scholar 

Zhou B, Wen M, Lin X, Chen YH, Gou Y, Li Y, et al. Alpha lipoamide ameliorates motor deficits and mitochondrial dynamics in the parkinson’s disease model induced by 6-hydroxydopamine. Neurotox Res. 2018;33:759–67.

CAS  PubMed  Google Scholar 

Soulage CO, Pelletier CC, Florens N, Lemoine S, Dubourg L, Juillard L, et al. Two Toxic Lipid Aldehydes, 4-hydroxy-2-hexenal (4-HHE) and 4 -hydroxy-nonenal (4-HNE), accumulate in patients with chronic kidney disease. Toxins. 2020;12:567.

CAS  PubMed Central  Google Scholar 

Quirós PM, Mottis A, Auwerx J. Mitonuclear communication in homeostasis and stress. Nat Rev Mol Cell Biol. 2016;17:213–26.

PubMed  Google Scholar 

Ouamrane L, Larrieu G, Gauthier B, Pineau T. RXR activators molecular signalling: Involvement of a PPAR alpha-dependent pathway in the liver and kidney, evidence for an alternative pathway in the heart. Br J Pharmacol. 2003;138:845–54.

CAS  Google Scholar 

Annesley SJ, Fisher PR. Mitochondria in health and disease. Cells. 2019;8:680.

CAS  PubMed Central  Google Scholar 

Yapa NMB, Lisnyak V, Reljic B, Ryan MT. Mitochondrial dynamics in health and disease. FEBS Lett. 2021;595:1184–204.

CAS  PubMed  Google Scholar 

Bhargava P, Schnellmann RG. Mitochondrial energetics in the kidney. Nat Rev Nephrol. 2017;13:629–46.

CAS  PubMed  PubMed Central  Google Scholar 

Jiménez-Uribe AP, Hernández-Cruz EY, Ramírez-Magaña KJ, Pedraza-Chaverri J. Involvement of tricarboxylic acid cycle metabolites in kidney diseases. Biomolecules. 2021;11:1259.

PubMed  PubMed Central  Google Scholar 

Wu Y, Chen M, Jiang J. Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling. Mitochondrion. 2019;49:35–45.

CAS  PubMed  Google Scholar 

Irazabal MV, Torres VE. Reactive oxygen species and redox signaling in chronic kidney disease. Cells. 2020;9:1342.

CAS  PubMed Central  Google Scholar 

Persson HL, Svensson AI, Brunk UT. Alpha-lipoic acid and alpha-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis. Redox Rep. 2001;6:327–34.

CAS  PubMed  Google Scholar 

Zhang XK, Su Y, Chen L, Chen F, Liu J, Zhou H. Regulation of the nongenomic actions of retinoid X receptor-αby targeting the coregulator-binding sites. Acta Pharmacol Sin. 2015;36:102–12.

PubMed  Google Scholar 

De Bosscher K, Desmet SJ, Clarisse D, Estébanez-Perpiña E, Brunsveld L. Nuclear receptor crosstalk - defining the mechanisms for therapeutic innovation. Nat Rev Endocrinol. 2020;16:363–77.

PubMed  Google Scholar 

Lu Z, Liu H, Fu W, Wang Y, Geng J, Wang Y, et al. 20(S)-Protopanaxadiol inhibits epithelial-mesenchymal transition by promoting retinoid X receptor alpha in human colorectal carcinoma cells. J Cell Mol Med. 2020;24:14349–65.

CAS  PubMed  PubMed Central  Google Scholar 

Tunctan B, Kucukkavruk SP, Temiz-Resitoglu M, Guden DS, Sari AN, Sahan-Firat S, et al. Bexarotene, a selective RXRα agonist, reverses hypotension associated with inflammation and tissue injury in a rat model of septic shock. Inflammation. 2018;41:337–55.

CAS  PubMed  Google Scholar 

Li JE, Futawaka K, Yamamoto H, Kasahara M, Tagami T, Liu TH, et al. Cinnamaldehyde contributes to insulin sensitivity by activating PPARδ, PPARγ, and RXR. Am J Chin Med. 2015;43:879–92.

CAS  PubMed  Google Scholar 

Chai D, Lin X, Zheng Q, Xu C, Xie H, Ruan Q, et al. Retinoid X receptor agonists attenuates cardiomyopathy in streptozotocin-induced type 1 diabetes through LKB1-dependent anti-fibrosis effects. Clin Sci. 2020;134:609–28.

CAS  Google Scholar 

Ayala-Peña VB, Pilotti F, Volonté Y, Rotstein NP, Politi LE, German OL. Protective effects of retinoid x receptors on retina pigment epithelium cells. Biochim Biophys Acta. 2016;1863:1134–45.

PubMed  Google Scholar 

Wang HB, Wei H, Wang JS, Li L, Chen AY, Li ZG. Down-regulated expression of LINC00518 prevents epithelial cell growth and metastasis in breast cancer through the inhibition of CDX2 methylation and the Wnt signaling pathway. Biochim Biophys Acta Mol Basis Dis. 2019;1865:708–23.

CAS  PubMed  Google Scholar 

Schunk SJ, Floege J, Fliser D, Speer T. WNT-β-catenin signalling—a versatile player in kidney injury and repair. Nat Rev Nephrol. 2021;17:172–84.

CAS  PubMed  Google Scholar 

Simon-Tillaux N, Hertig A. Snail and kidney fibrosis. Nephrol Dial Transpl. 2017;32:224–33.

CAS  Google Scholar 

Gnemmi V, Bouillez A, Gaudelot K, Hémon B, Ringot B, Pottier N, et al. MUC1 drives epithelial-mesenchymal transition in renal carcinoma through Wnt/β-catenin pathway and interaction with SNAIL promoter. Cancer Lett. 2014;346:225–36.

CAS  PubMed  Google Scholar 

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