Knopman DS, Jones DT, Greicius MD. Failure to demonstrate efficacy of aducanumab: an analysis of the EMERGE and ENGAGE trials as reported by Biogen, December 2019”. Alzheimers Dement. 2021;17(4):696–701.
Singh CSB, Choia KB, Munroa L, Wanga HY, Pfeifera C, Jefferies W. Reversing pathology in a preclinical model of Alzheimer’s disease by hacking cerebrovascular neoangiogenesis with advanced cancer therapeutics. EBioMedicine. 2021. https://doi.org/10.1016/j.ebiom.2021.103503.
Article PubMed PubMed Central Google Scholar
Ancidoni A, Bacigalupo I, Remoli G, Lacorte E, Piscopo P, Sarti G, Corbo M, Vanacore N, Canevelli M. Anticancer drugs repurposed for Alzheimer’s disease: a systematic review. Alzheimers Res Ther. 2021;13(1):96. https://doi.org/10.1186/s13195-021-00831-6.PMID:33952306;PMCID:PMC8101105.
Article PubMed PubMed Central Google Scholar
Biessels GJ, Strachan MW, Visseren FL, Kappelle LJ, Whitmer RA. Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions. Lancet Diabetes Endocrinol. 2014;2:246–55.
Ng RC, Cheng OY, Jian M, Kwan JS, Ho PW, Cheng KK, et al. Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice. Mol Neurodegener. 2016;11:71–80.
PubMed PubMed Central Google Scholar
Kang S, Kim CH, Jung H, Kim E, Song HT, Lee JE. Agmatine ameliorates type 2 diabetes induced-Alzheimer’s disease-like alterations in high-fat-diet-fed mice via reactivation of blunted insulin signalling. Neuropharmacology. 2017;113:467–79.
Gomaa AA, Makboul R, Al-Mokhtar M, Abdel-Rahman E, Ahmed I, Nicola M. Terpenoid-rich Elettaria cardamomum extract prevents Alzheimer-like alterations induced in diabetic rats via inhibition of GSK3β activity, oxidative stress and pro-inflammatory cytokines. Cytokine. 2019;113:405–16.
Mukherjee A, Soto C. Prion-like protein aggregates and type 2 Diabetes. Cold Spring Harb Perspect Med. 2017;7: a024315.
PubMed PubMed Central Google Scholar
Ma L, Xu GB, Tang X, Zhang C, Zhao W, Wang J, Chen H. Anti-cancer potential of polysaccharide extracted from hawthorn (Crataegus) on human colon cancer cell line HCT116 via cell cycle arrest and apoptosis. J Funct Foods. 2019;64: 103677.
Wang X, Chen Y, Fang Z. In-vitro photothermal therapy using plant extract polyphenols functionalized graphene sheets for treatment of lung cancer. J Photochem Photobioi B: Biology. 2019;204:111587–601.
Ali Abdalla YO, Subramaniam B, Nyamathulla S, Shamsuddin N, Arshad NM, Mun KS, Awang K, Nagoor NH. Natural products for cancer therapy: a review of their mechanism of actions and toxicity in the past decade. J Trop Med. 2022;11(2022):5794350. https://doi.org/10.1155/2022/5794350.
Freyssin A, Page G, Fauconneau B, Bilan A. Natural polyphenols effects on protein aggregates in Alzheimer’s and Parkinson’s prion-like diseases. Neural Regen Res. 2018;13:955–61.
CAS PubMed PubMed Central Google Scholar
Dhouafli Z, Cuanalo-Contreras K, Hayouni E, Mays C, et al. Inhibition of protein misfolding and aggregation by natural phenolic compounds. Cell Mol Life Sci. 2018;75(19):3521–38.
Gomaa AA, Makboul R, Al-Mokhtarc M, Nicola M. Polyphenol-rich Boswellia serrata gum prevents cognitive impairment and insulin resistance of diabetic rats through inhibition of GSK3β activity, oxidative stress and pro-inflammatory cytokines. Biomed Pharmacother. 2019;2919(109):281–92.
Nassar M, Elshamy A, Gendy A.,2014. Phenolics, essential oil and biological activity of Conyza dioscoridis growing in Egypt. Planta Med. 2014,80 - LP15
Awaad AS, El-meligy RM, Qenawy SA, Atta AH, Soliman GA. Anti-inflammatory, antinociceptive and antipyretic effects of some desert plants. J Saudi Chem Soc. 2011;15:367–73.
El Zalabani SM, Hetta MH, Ismail AS. Anti-inflammatory and antimicrobial activity of the different Conyza dioscoridis L. Desf organs Biosafety. 2013;2:1–3.
El Zalabani S, Hetta M, Ross S, Abo Youssef A, Zaki M, Ismail A. Antihyperglycemic and antioxidant activities and chemical composition of Conyza dioscoridis (L.) Desf. DC. growing in Egypt. Aust J Basic Applied Sci. 2012;6:257–65.
El shamy A, Gendy A., Farrag A, Nassar M. Antidiabetic and antioxidant activities of phenolic extracts of conyza Dioscoridis L. Int J Pharm Pharm Sci. 2015;7:65–72.
Hamed MM, Mohamed MA, Ibrahim MT. Phytochemical investigation and cytotoxic characterization of bioactive constituents from Conyza dioscoridis. Planta Med 2015; 81 - PW_76 DOI: https://doi.org/10.1055/s-0035-1565700
Araujo L, Moujir LM, Rojas J, Rojas L, Carmona J, Rondón M. Chemical composition and biological activity of Conyza bonariensis essential oil collected in Mérida. Venezuela Nat Prod Commun. 2013;8(8):1175–8 (PMID: 24079198).
Elgamal A.M., Ahmed R.F., Abd-ElGawad A.M., El Gendy A.E.-N.G., Elshamy A.I., Nassar M.I. Chemical profiles, anticancer, and anti-aging activities of Essential Oils of Pluchea dioscoridis (L.) DC. and Erigeron bonariensis L. Plants. 2021;10:667. https://doi.org/10.3390/plants10040667.
Article CAS PubMed PubMed Central Google Scholar
Peng L, Hu C, Zhang C, Lu Y, Man S, Ma L. Anti-cancer activity of Conyza blinii saponin against cervical carcinoma through MAPK/TGF-β/Nrf2 signaling pathways. J Ethnopharmacol. 2020;251: 112503. https://doi.org/10.1016/j.jep.2019.112503.
Article CAS PubMed Google Scholar
Karray A, Alonazi M, Smaoui S, Michaud P, Soliman D, Ben BA. Purification and biochemical characterization of a new protease inhibitor from Conyza dioscoridis with antimicrobial, antifungal and cytotoxic effects. Molecules. 2020;25(22):5452. https://doi.org/10.3390/molecules25225452.PMID:33233753;PMCID:PMC7699837.
Article CAS PubMed Central Google Scholar
Bonturi CR, Silva Teixeira AB, Rocha VM, et al. Plant Kunitz Inhibitors and Their Interaction with Proteases: Current and Potential Pharmacological Targets. Int J Mol Sci. 2022;23(9):4742. Published 2022 Apr 25. doi:https://doi.org/10.3390/ijms23094742
Ebert U, Kirch W. Scopolamine models of dementia electroencephalogram findings and cognitive performance. Eur J Clin Invest. 1998;28:944–9.
Van Dam D, De Deyn PP. Animal models in the drug discovery pipeline for Alzheimer’s disease. Br J Pharmacol. 2011;2011(164):1285–300.
Nuzzo D, Picone P, Baldassano S, Caruana L, Messina E, Marino GA, et al. Insulin resistance as common molecular denominator linking obesity to Alzheimer’s disease. Curr Alzheimer Res. 2015;2015(12):723–35.
Niu L, Han DW, Xu RL, Han B, Zhou X, Wu HW, et al. A high-sugar high-fat diet-induced metabolic syndrome shows some symptoms of Alzheimer’s disease in rats. J Nutr Health Aging. 2016;2016(20):509–13.
Kang S, Lee YH, Lee JE. Metabolism-centric overview of the pathogenesis of Alzheimer’s disease. Yonsei Med J. 2017;58:479–88.
CAS PubMed PubMed Central Google Scholar
Lee TT, Huang CC, Shieh XH, Chen CL, Chen LJ, Yu B. Flavonoid, phenol and polysaccharide contents of Echinacea purpurea l. and its immunostimulant capacity in vitro. Int J Environ Sci and Develop. 2010;1:5–9.
Chang C, Yang M, Wen H, Chern J. Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J Food Drug Anal. 2002;10:178–82.
Ping KY, Darah I, Yusuf UK, Latha LY, Sasidharan S. Standardization of Euphorbia hirta with Chemical Compounds Identification (GC-MS). Int J Phytomed. 2012;4:12–21.
Nath P, Yadav AK. Acute and sub-acute oral toxicity assessment of the methanolic extract from leaves of Hibiscus rosa-sinensis L. in mice. J Intercult Ethnopharmacol. 2015;4(1):70–3. https://doi.org/10.5455/jice.20141028021746.
Article CAS PubMed Google Scholar
Ozarowski M, Mikolajczak PL, Bogacz A, Gryszczynska A, Kujawska M, et al. Rosmarinus officinalis L. leaf extract improves memory impairment and affects acetylcholinesterase and butyrylcholinesterase activities in rat brain. Fitoterapia. 2013,;91:261–71.
Zhang F, Ye C, Li G, Ding W, Zhou W, Zhu H, et al. The rat model of type 2 diabetic mellitus and its glycometabolism characters. Exp Anim. 2003;52:401–7.
Anderson RA, Qin B, Canini F, Poulet L, Roussel AM. Cinnamon counteracts the negative effects of a high fat/high fructose diet on behavior, brain insulin signaling and Alzheimer-associated changes. PLoS ONE. 2013;8: e83243.
PubMed PubMed Central Google Scholar
Xiang X, Wang Z, Zhu Y, Bian L, Yang Y. Dosage of streptozocin in inducing rat model of type 2 diabetes mellitus. Wei Sheng Yan Jiu. 2010;2010(39):138–42.
Lin HB, Yang XM, Li TJ, Cheng YF, Zhang HT, Xu JP. Memory deficits and neurochemical changes induced by C-reactive protein in rats: implication in Alzheimer’s disease. Psychopharmacology. 2009;204:705–14.
Shin SC, Lee DU. Ameliorating effect of new constituents from the hooks of Uncaria rhynchophylla on scopolamine-induced memory impairment. Chin J Nat Med. 2013;11:391–5.
Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, et al. Biochemical and immunohistochemical analysis of an Alzheimer’s disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiol Dis. 2009;36:293–302.
CAS PubMed PubMed Central Google Scholar
Wang X, Ge A, Cheng M, Guo F, Zhao M, Zhou X, et al. Increased hypothalamic inflammation associated with the susceptibility to obesity in rats exposed to high-fat diet. Exp Diabetes Res. 2012;2012:847246.
PubMed PubMed Central Google Scholar
Gomaa AA, Farghaly HSM, El-Sers DA, Farrag MM, Al-Zokeim NI. Inhibition of adiposity and related metabolic disturbances by polyphenol-rich extract of Boswellia serrata gum through alteration of adipo/cytokine profiles. Inflammopharmacology. 2019;27(3):549–59.
Glushakova OY, Glushakov AA, Wijesinghe DS, Valadka AB, Hayes RL, et al. Prospective clinical biomarkers of caspase-mediated apoptosis associated with neuronal and neurovascular damage following stroke and other severe brain injuries: implications for chronic neurodegeneration. Brain Circ. 2017;3:87–108.
PubMed PubMed Central Google Scholar
Plaschke K, Kopitz J. In vitro streptozotocin model for modeling Alzheimer-like changes: effect on amyloid precursor protein secretases and glycogen synthase kinase-3. J Neural Transm (Vienna). 2015;122:551–7.
Barichello T, dos S, I, Savi GD, Simoes LR, Silvestre T, Comim CM
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