Alappat EC, Volkland J, Peter ME. Cell cycle effects by C-FADD depend on its C-terminal phosphorylation site. J Biol Chem. 2003;278(43):41585–8.
Alappat EC, Feig C, Boyerinas B, Volkland J, Samuels M, Murmann AE, et al. Phosphorylation of FADD at serine 194 by CKIalpha regulates its nonapoptotic activities. Mol Cell. 2005;19(3):321–32.
Antunovic M, Matic I, Nagy B, Caput Mihalic K, Skelin J, Stambuk J, et al. FADD-deficient mouse embryonic fibroblasts undergo RIPK1-dependent apoptosis and autophagy after NB-UVB irradiation. J Photochem Photobiol B. 2019;194:32–45.
Ao X, Ding W, Ge H, Zhang Y, Ding D, Liu Y. PBX1 is a valuable prognostic biomarker for patients with breast cancer. Experimental and therapeutic medicine. 2020;20(1):385–94.
CAS PubMed PubMed Central Google Scholar
Bhojani MS, Chen G, Ross BD, Beer DG, Rehemtulla A. Nuclear localized phosphorylated FADD induces cell proliferation and is associated with aggressive lung cancer. Cell Cycle. 2005;4(11):1478–81.
Bowman BM, Sebolt KA, Hoff BA, Boes JL, Daniels DL, Heist KA, et al. Phosphorylation of FADD by the kinase CK1alpha promotes KRASG12D-induced lung cancer. Sci Signal. 2015;8(361):ra9.
PubMed PubMed Central Google Scholar
Brennan K, Lyons C, Fernandes P, Doyle S, Houston A, Brint E. Engagement of Fas differentially regulates the production of LPS-induced proinflammatory cytokines and type I interferons. FEBS J. 2019;286(3):523–35.
Brown LA, Kalloger SE, Miller MA, Shih Ie M, McKinney SE, Santos JL, et al. Amplification of 11q13 in ovarian carcinoma. Genes Chromosomes Cancer. 2008;47(6):481–9.
Cai F, Xu H, Cao N, Zhang X, Liu J, Lu Y, et al. ADT-OH, a hydrogen sulfide-releasing donor, induces apoptosis and inhibits the development of melanoma in vivo by upregulating FADD. Cell Death Dis. 2020;11(1):33.
CAS PubMed PubMed Central Google Scholar
Callegari CC, Cavalli IJ, Lima RS, Jucoski TS, Torresan C, Urban CA, et al. Copy number and expression analysis of FOSL1, GSTP1, NTSR1, FADD and CCND1 genes in primary breast tumors with axillary lymph node metastasis. Cancer Genet. 2016;209(7–8):331–9.
Chaithongyot S, Jantaree P, Sokolova O, Naumann M. NF-kappaB in Gastric Cancer Development and Therapy. Biomedicines. 2021;9(8).
Chang W, Li M, Song L, Miao S, Yu W, Wang J. Noncoding RNAs from tissue-derived small extracellular vesicles: Roles in diabetes and diabetic complications. Mol Metab. 2022a;58:101453.
CAS PubMed PubMed Central Google Scholar
Chang W, Wang M, Zhang Y, Yu F, Hu B, Goljanek-Whysall K, et al. Roles of long noncoding RNAs and small extracellular vesicle-long noncoding RNAs in type 2 diabetes. Traffic. 2022b.
Chaudhary PM, Eby MT, Jasmin A, Kumar A, Liu L, Hood L. Activation of the NF-kappaB pathway by caspase 8 and its homologs. Oncogene. 2000;19(39):4451–60.
Chen G, Bhojani MS, Heaford AC, Chang DC, Laxman B, Thomas DG, et al. Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas. Proc Natl Acad Sci U S A. 2005;102(35):12507–12.
CAS PubMed PubMed Central Google Scholar
Chen L, Xie G, Feng J, Wen Q, Zang H, Lu J, et al. Overexpression of FADD and Bcl-XS proteins as novel prognostic biomarkers for surgically resected non-small cell lung cancer. Cancer Biomark. 2021;30(2):145–54.
Chien HT, Cheng SD, Chuang WY, Liao CT, Wang HM, Huang SF. Clinical Implications of FADD Gene Amplification and Protein Overexpression in Taiwanese Oral Cavity Squamous Cell Carcinomas. PLoS ONE. 2016;11(10):e0164870.
PubMed PubMed Central Google Scholar
Choi EJ, Yun JA, Jabeen S, Jeon EK, Won HS, Ko YH, et al. Prognostic significance of TMEM16A, PPFIA1, and FADD expression in invasive ductal carcinoma of the breast. World J Surg Oncol. 2014;12:137.
PubMed PubMed Central Google Scholar
Choi SG, Kim H, Jeong EI, Lee HJ, Park S, Lee SY, et al. SUMO-Modified FADD Recruits Cytosolic Drp1 and Caspase-10 to Mitochondria for Regulated Necrosis. Mol Cell Biol. 2017;37(2).
Cimino Y, Costes A, Damotte D, Validire P, Mistou S, Cagnard N, et al. FADD protein release mirrors the development and aggressiveness of human non-small cell lung cancer. Br J Cancer. 2012;106(12):1989–96.
CAS PubMed PubMed Central Google Scholar
Cui H, Weng Y, Ding N, Cheng C, Wang L, Zhou Y, et al. Autophagy-Related Three-Gene Prognostic Signature for Predicting Survival in Esophageal Squamous Cell Carcinoma. Front Oncol. 2021;11:650891.
PubMed PubMed Central Google Scholar
Debnath S, Sarkar A, Mukherjee DD, Ray S, Mahata B, Mahata T, et al. Eriodictyol mediated selective targeting of the TNFR1/FADD/TRADD axis in cancer cells induce apoptosis and inhibit tumor progression and metastasis. Transl Oncol. 2022;21:101433.
CAS PubMed PubMed Central Google Scholar
Eberstadt M, Huang B, Chen Z, Meadows RP, Ng SC, Zheng L, et al. NMR structure and mutagenesis of the FADD (Mort1) death-effector domain. Nature. 1998;392(6679):941–5.
Ehlken H, Krishna-Subramanian S, Ochoa-Callejero L, Kondylis V, Nadi NE, Straub BK, et al. Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout. Cell Death Differ. 2014;21(11):1721–32.
CAS PubMed PubMed Central Google Scholar
Eytan DF, Snow GE, Carlson S, Derakhshan A, Saleh A, Schiltz S, et al. SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2. Cancer Res. 2016;76(18):5442–54.
CAS PubMed PubMed Central Google Scholar
Fan S, Muller S, Chen ZG, Pan L, Tighiouart M, Shin DM, et al. Prognostic impact of Fas-associated death domain, a key component in death receptor signaling, is dependent on the presence of lymph node metastasis in head and neck squamous cell carcinoma. Cancer Biol Ther. 2013;14(4):365–9.
CAS PubMed PubMed Central Google Scholar
Fan Y, Li X, Zhang L, Zong Z, Wang F, Huang J, et al. SUMOylation in Viral Replication and Antiviral Defense. Adv Sci (Weinh). 2022;9(7):e2104126.
Feng S, Ma L, Yang Y, Wu M. Truncated RIP3 (tRIP3) acts upstream of FADD to induce apoptosis in the human hepatocellular carcinoma cell line QGY-7703. Biochem Biophys Res Commun. 2006;347(3):558–65.
Fox JL, Hughes MA, Meng X, Sarnowska NA, Powley IR, Jukes-Jones R, et al. Cryo-EM structural analysis of FADD:Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate. Nat Commun. 2021;12(1):819.
CAS PubMed PubMed Central Google Scholar
Ge L, Zhang X, Hu S, Song Y, Kong J, Zhang B, et al. H19 suppresses the growth of hepatoblastoma cells by promoting their apoptosis via the signaling pathways of miR-675/FADD and miR-138/PTK2. J Cell Biochem. 2019;120(4):5218–31.
Gibcus JH, Menkema L, Mastik MF, Hermsen MA, de Bock GH, van Velthuysen ML, et al. Amplicon mapping and expression profiling identify the Fas-associated death domain gene as a new driver in the 11q13.3 amplicon in laryngeal/pharyngeal cancer. Clin Cancer Res. 2007;13(21):6257–66.
Gomez-Angelats M, Cidlowski JA. Molecular evidence for the nuclear localization of FADD. Cell Death Differ. 2003;10(7):791–7.
Gonzalez-Moles MA, Ayen A, Gonzalez-Ruiz I, de Porras-Carrique T, Gonzalez-Ruiz L, Ruiz-Avila I, et al. Prognostic and Clinicopathological Significance of FADD Upregulation in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. Cancers. 2020;12(9).
Goto E, Tokunaga F. Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP. Biochem Biophys Res Commun. 2017;485(1):152–9.
Han B, Meng X, Wu P, Li Z, Li S, Zhang Y, et al. ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma. Theranostics. 2020;10(7):3351–65.
CAS PubMed PubMed Central Google Scholar
Harari-Steinfeld R, Gefen M, Simerzin A, Zorde-Khvalevsky E, Rivkin M, Ella E, et al. The lncRNA H19-Derived MicroRNA-675 Promotes Liver Necroptosis by Targeting FADD. Cancers. 2021;13(3).
Hartwig T, Montinaro A, von Karstedt S, Sevko A, Surinova S, Chakravarthy A, et al. The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2. Mol Cell. 2017;65(4):730–42. e5.
CAS PubMed PubMed Central Google Scholar
He L, Ren Y, Zheng Q, Wang L, Lai Y, Guan S, et al. Fas-associated protein with death domain (FADD) regulates autophagy through promoting the expression of Ras homolog enriched in brain (Rheb) in human breast adenocarcinoma cells. Oncotarget. 2016;7(17):24572–84.
PubMed PubMed Central Google Scholar
He X, Peng X, Liu Y, Zhang X, Li H, Yin H. Adenovirus-mediated overexpression FADD induces a significant antitumor effect on human colorectal cancer cells both in vitro and in vivo. Cell Mol Biol (Noisy-le-grand). 2018;64(6):31–5.
Henry CM, Martin SJ. Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory “FADDosome” Complex upon TRAIL Stimulation. Mol Cell. 2017;65(4):715–29. e5.
Hindryckx P, De Vos M, Jacques P, Ferdinande L, Peeters H, Olievier K, et al. Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD. J Immunol. 2010;185(10):6306–16.
Hollomon MG, Patterson L, Santiago-O’Farrill J, Kleinerman ES, Gordon N. Knock down of Fas-Associated Protein with Death Domain (FADD) Sensitizes Osteosarcoma to TNFalpha-induced Cell Death. J Cancer. 2020;11(7):1657–67.
CAS PubMed PubMed Central Google Scholar
Hu WH, Johnson H, Shu HB. Activation of NF-kappaB by FADD, Casper, and caspase-8. J Biol Chem. 2000;275(15):10838–44.
Ikeda T, Tanaka N, Shimada K, Matsumura Y, Miyake M, Anai S, et al. Phosphorylation status of Fas-associated death domain protein is associated with biochemical recurrence after radical prostatectomy. Urology. 2013;81(3):607–10.
Imtiyaz HZ, Zhou X, Zhang H, Chen D, Hu T, Zhang J. The death domain of FADD is essential for embryogenesis, lymphocyte development, and proliferation.
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