Kang J, Brajanovski N, Chan KT, Xuan J, Pearson RB, Sanij E. Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy. Signal Transduct Target Ther. 2021;6:323.

CAS  PubMed  PubMed Central  Google Scholar 

Cui K, Liu C, Li X, Zhang Q, Li Y. Comprehensive characterization of the rRNA metabolism-related genes in human cancer. Oncogene 2020;39:786–800.

CAS  PubMed  Google Scholar 

Boczonadi V, Muller JS, Pyle A, Munkley J, Dor T, Quartararo J, et al. EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia. Nat Commun. 2014;5:4287.

CAS  PubMed  Google Scholar 

Muller JS, Burns DT, Griffin H, Wells GR, Zendah RA, Munro B, et al. RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels. Life Sci Alliance. 2020;3:e202000678.

PubMed  PubMed Central  Google Scholar 

Liu Q, Xiao Q, Sun Z, Wang B, Wang L, Wang N, et al. Exosome component 1 cleaves single-stranded DNA and sensitizes human kidney renal clear cell carcinoma cells to poly(ADP-ribose) polymerase inhibitor. Elife. 2021;10:e69454.

PubMed  PubMed Central  Google Scholar 

Taniue K, Tanu T, Shimoura Y, Mitsutomi S, Han H, Kakisaka R, et al. RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is Required for the Cancer Cell Survival. Int J Mol Sci. 2022;23:496.

PubMed  PubMed Central  Google Scholar 

Chen X, Huang Y, Liu J, Lin W, Chen C, Chen Y, et al. EXOSC5 promotes proliferation of gastric cancer through regulating AKT/STAT3 signaling pathways. J Cancer. 2022;13:1456–67.

CAS  PubMed  PubMed Central  Google Scholar 

Pan H, Pan J, Song S, Ji L, Lv H, Yang Z. EXOSC5 as a Novel Prognostic Marker Promotes Proliferation of Colorectal Cancer via Activating the ERK and AKT Pathways. Front Oncol. 2019;9:643.

PubMed  PubMed Central  Google Scholar 

Prakash V, Carson BB, Feenstra JM, Dass RA, Sekyrova P, Hoshino A, et al. Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease. Nat Commun. 2019;10:2110.

PubMed  PubMed Central  Google Scholar 

Hong F, Meng Q, Zhang W, Zheng R, Li X, Cheng T, et al. Single-Cell Analysis of the Pan-Cancer Immune Microenvironment and scTIME Portal. Cancer Immunol Res. 2021;9:939–51.

CAS  PubMed  Google Scholar 

Pelletier J, Thomas G, Volarevic S. Ribosome biogenesis in cancer: new players and therapeutic avenues. Nat Rev Cancer. 2018;18:51–63.

CAS  PubMed  Google Scholar 

Morral C, Stanisavljevic J, Hernando-Momblona X, Mereu E, Alvarez-Varela A, Cortina C, et al. Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer. Cell Stem Cell. 2020;26:845–861.e812.

CAS  PubMed  PubMed Central  Google Scholar 

Zanchin NI, Goldfarb DS. The exosome subunit Rrp43p is required for the efficient maturation of 5.8S, 18S and 25S rRNA. Nucl Acids Res. 1999;27:1283–8.

CAS  PubMed  PubMed Central  Google Scholar 

Garden GA, Hartlage-Rubsamen M, Rubel EW, Bothwell MA. Protein masking of a ribosomal RNA epitope is an early event in afferent deprivation-induced neuronal death. Mol Cell Neurosci. 1995;6:293–310.

CAS  PubMed  Google Scholar 

Boutelle AM, Attardi LD. p53 and Tumor Suppression: It Takes a Network. Trends Cell Biol. 2021;31:298–310.

CAS  PubMed  PubMed Central  Google Scholar 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci. 2005;102:15545–50.

CAS  PubMed  PubMed Central  Google Scholar 

Deisenroth C, Zhang Y. Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway. Oncogene 2010;29:4253–60.

CAS  PubMed  Google Scholar 

Hein N, Hannan KM, George AJ, Sanij E, Hannan RD. The nucleolus: an emerging target for cancer therapy. Trends Mol Med. 2013;19:643–54.

CAS  PubMed  Google Scholar 

Jhan YY, Prasca-Chamorro D, Palou Zuniga G, Moore DM, Arun Kumar S, Gaharwar AK, et al. Engineered extracellular vesicles with synthetic lipids via membrane fusion to establish efficient gene delivery. Int J Pharm. 2020;573:118802.

CAS  PubMed  Google Scholar 

Ferdows BE, Patel DN, Chen W, Huang X, Kong N, Tao W. RNA cancer nanomedicine: nanotechnology-mediated RNA therapy. Nanoscale 2022;14:4448–55.

CAS  PubMed  Google Scholar 

Zhang Y, Liu Q, Zhang X, Huang H, Tang S, Chai Y, et al. Recent advances in exosome-mediated nucleic acid delivery for cancer therapy. J Nanobiotechnology. 2022;20:279.

CAS  PubMed  PubMed Central  Google Scholar 

Yang B, Chen Y, Shi J. Exosome Biochemistry and Advanced Nanotechnology for Next-Generation Theranostic Platforms. Adv Mater. 2019;31:e1802896.

PubMed  Google Scholar 

Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. 2011;29:341–5.

CAS  PubMed  Google Scholar 

van Eijndhoven MAJ, Baglio SR, Pegtel DM. Packaging RNA drugs into extracellular vesicles. Nat Biomed Eng. 2020;4:6–8.

PubMed  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71:209–49.

PubMed  Google Scholar 

Zheng R, Zhang S, Zeng H, Wang S, Sun K, Chen R, et al. Cancer incidence and mortality in China, 2016. J Natl Cancer Cent. 2022;2:1–9.

Google Scholar 

Morton DJ, Kuiper EG, Jones SK, Leung SW, Corbett AH, Fasken MB. The RNA exosome and RNA exosome-linked disease. RNA 2018;24:127–42.

CAS  PubMed  PubMed Central  Google Scholar 

Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646–74.

CAS  PubMed  Google Scholar 

Shen A, Chen Y, Liu L, Huang Y, Chen H, Qi F, et al. EBF1-Mediated Upregulation of Ribosome Assembly Factor PNO1 Contributes to Cancer Progression by Negatively Regulating the p53 Signaling Pathway. Cancer Res. 2019;79:2257–70.

CAS  PubMed  Google Scholar 

Li W, Cui K, Prochownik EV, Li Y. The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth. Cell Death Dis. 2018;9:482.

CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Cui K, Zhang Q, Li X, Lin X, Tang Y, et al. FBXL6 degrades phosphorylated p53 to promote tumor growth. Cell Death Differ. 2021;28:2112–25.

CAS  PubMed  PubMed Central  Google Scholar 

Zhu Y, Gu L, Lin X, Zhou X, Lu B, Liu C et al. P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis. Hepatology. 2022. https://doi.org/10.1002/hep.32518.

Cao P, Yang A, Li P, Xia X, Han Y, Zhou G et al. Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling. Sci Adv. 2021;7:eabf4304.

Yu ZK, Geyer RK, Maki CG. MDM2-dependent ubiquitination of nuclear and cytoplasmic P53. Oncogene 2000;19:5892–7.

CAS  PubMed  Google Scholar 

Shirangi TR, Zaika A, Moll UM. Nuclear degradation of p53 occurs during down-regulation of the p53 response after DNA damage. FASEB J. 2002;16:420–2.

CAS  PubMed  Google Scholar 

Jiang T, Altman S. A protein subunit of human RNase P, Rpp14, and its interacting partner, OIP2, have 3’–>5’ exoribonuclease activity. Proc Natl Acad Sci. 2002;99:5295–300.

CAS  PubMed  PubMed Central  Google Scholar 

Lee HO, Hong Y, Etlioglu HE, Cho YB, Pomella V, Van den Bosch B, et al. Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer. Nat Genet. 2020;52:594–603.

CAS  PubMed  Google Scholar 

Hao Y, Hao S, Andersen-Nissen E, Mauck WM 3rd, Zheng S, Butler A, et al. Integrated analysis of multimodal single-cell data. Cell 2021;184:3573–87e3529.

CAS  PubMed  PubMed Central  Google Scholar 

Andreatta M, Carmona SJ. UCell: Robust and scalable single-cell gene signature scoring. Comput Struct Biotechnol J. 2021;19:3796–8.

CAS  PubMed  PubMed Central  Google Scholar 

Gao R, Bai S, Henderson YC, Lin Y, Schalck A, Yan Y, et al. Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes. Nat Biotechnol. 2021;39:599–608.

CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Cui K, Huang L, Yang F, Sun S, Bian Z, et al. SLCO4A1-AS1 promotes colorectal tumourigenesis by regulating Cdk2/c-Myc signalling. J Biomed Sci. 2022;29:4.

PubMed  PubMed Central  Google Scholar 

Cui K, Yao S, Zhang H, Zhou M, Liu B, Cao Y, et al. Identification of an immune overdrive high-risk subpopulation with aberrant expression of FOXP3 and CTLA4 in colorectal cancer. Oncogene 2021;40:2130–45.

CAS  PubMed  Google Scholar 

Gong L, Li Y, Cui K, Chen Y, Hong H, Li J, et al. Nanobody-Engineered Natural Killer Cell Conjugates for Solid Tumor Adoptive Immunotherapy. Small 2021;17:e2103463.

PubMed  Google Scholar 

Bian Z, Zhou M, Cui K, Yang F, Cao Y, Sun S, et al. SNHG17 promotes colorectal tumorigenesis and metastasis via regulating Trim23-PES1 axis and miR-339-5p-FOSL2-SNHG17 positive feedback loop. J Exp Clin Cancer Res. 2021;40:360.

CAS  PubMed  PubMed Central