Wang Y, Tao Y, Hyman ME, Li J, Chen Y. Osteoporosis in china. Osteoporos Int. 2009;20:1651–62.

CAS  PubMed  Google Scholar 

Neugebauer J, Heilig J, Hosseinibarkooie S, Ross BC, Mendoza-Ferreira N, Nolte F, Peters M, Holker I, Hupperich K, Tschanz T, Grysko V, Zaucke F, Niehoff A, Wirth B. Plastin 3 influences bone homeostasis through regulation of osteoclast activity. Hum Mol Genet. 2018;27:4249–62.

CAS  PubMed  Google Scholar 

Lane NE. Epidemiology, etiology, and diagnosis of osteoporosis. Am J Obstet Gynecol. 2006;194:S3-11.

CAS  PubMed  Google Scholar 

Qadir A, Liang S, Wu Z, Chen Z, Hu L, Qian A. Senile osteoporosis: the involvement of differentiation and senescence of bone marrow stromal cells. Int J Mol Sci. 2020;21:349.

CAS  PubMed Central  Google Scholar 

Montalcini T, Romeo S, Ferro Y, Migliaccio V, Gazzaruso C, Pujia A. Osteoporosis in chronic inflammatory disease: the role of malnutrition. Endocrine. 2013;43:59–64.

CAS  PubMed  Google Scholar 

Fischer V, Haffner-Luntzer M. Interaction between bone and immune cells: implications for postmenopausal osteoporosis. Semin Cell Dev Biol. 2021;123:14–21.

PubMed  Google Scholar 

Hardy RS, Zhou H, Seibel MJ, Cooper MS. Glucocorticoids and bone: consequences of endogenous and exogenous excess and replacement therapy. Endocr Rev. 2018;39:519–48.

PubMed  Google Scholar 

Zhao F, Guo L, Wang X, Zhang Y. Correlation of oxidative stress-related biomarkers with postmenopausal osteoporosis: a systematic review and meta-analysis. Arch Osteoporos. 2021;16:4.

PubMed  Google Scholar 

Stoppoloni D, Politi L, Leopizzi M, Gaetani S, Guazzo R, Basciani S, Moreschini O, De Santi M, Scandurra R, Scotto d’Abusco A. Effect of glucosamine and its peptidyl-derivative on the production of extracellular matrix components by human primary chondrocytes. Osteoarthr Cartil. 2015;23:103–13.

CAS  Google Scholar 

Reginster JY, Neuprez A, Lecart MP, Sarlet N, Bruyere O. Role of glucosamine in the treatment for osteoarthritis. Rheumatol Int. 2012;32:2959–67.

CAS  PubMed  PubMed Central  Google Scholar 

Jiang Z, Li Z, Zhang W, Yang Y, Han B, Liu W, Peng Y. Dietary natural N-acetyl-d-glucosamine prevents bone loss in ovariectomized rat model of postmenopausal osteoporosis. Molecules. 2018;23:2302.

PubMed Central  Google Scholar 

Ali T, Badshah H, Kim TH, Kim MO. Melatonin attenuates d-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-K B/JNK signaling pathway in aging mouse model. J Pineal Res. 2015;58:71–85.

CAS  PubMed  Google Scholar 

Hsu WH, Shiao YJ, Chao YM, Huang YJ, Lin YL. T1–11, an adenosine derivative, ameliorates aging-related behavioral physiology and senescence markers in aging mice. Aging (Albany NY). 2020;12:10556–77.

CAS  Google Scholar 

Lv C, Wang L, Zhu X, Lin W, Chen X, Huang Z, Huang L, Yang S. Glucosamine promotes osteoblast proliferation by modulating autophagy via the mammalian target of rapamycin pathway. Biomed Pharmacother Biomed Pharmacother. 2018;99:271–7.

CAS  PubMed  Google Scholar 

Doherty J, Baehrecke EH. Life, death and autophagy. Nat Cell Biol. 2018;20:1110–7.

CAS  PubMed  Google Scholar 

Lenoir O, Jasiek M, Henique C, Guyonnet L, Hartleben B, Bork T, Chipont A, Flosseau K, Bensaada I, Schmitt A, Masse JM, Souyri M, Huber TB, Tharaux PL. Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis. Autophagy. 2015;11:1130–45.

CAS  PubMed  PubMed Central  Google Scholar 

Habieb ME, Mohamed MA, El Gamal DM, Hawas AM, Mohamed TM. Anti-aging effect of DL-beta-hydroxybutyrate against hepatic cellular senescence induced by d-galactose or gamma-irradiation via autophagic flux stimulation in male rats. Arch Gerontol Geriatr. 2021;92:104288.

CAS  PubMed  Google Scholar 

Lee J, Giordano S, Zhang J. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J. 2012;441:523–40.

CAS  PubMed  Google Scholar 

Li X, Xu J, Dai B, Wang X, Guo Q, Qin L. Targeting autophagy in osteoporosis: from pathophysiology to potential therapy. Ageing Res Rev. 2020;62:101098.

CAS  PubMed  Google Scholar 

McCormick JJ, Dokladny K, Moseley PL, Kenny GP. Autophagy and heat: a potential role for heat therapy to improve autophagic function in health and disease. J Appl Physiol. 2021;130:1–9.

CAS  PubMed  Google Scholar 

Luo D, Ren H, Li T, Lian K, Lin D. Rapamycin reduces severity of senile osteoporosis by activating osteocyte autophagy. Osteoporos Int. 2016;27:1093–101.

CAS  PubMed  Google Scholar 

Onal M, Piemontese M, Xiong J, Wang Y, Han L, Ye S, Komatsu M, Selig M, Weinstein RS, Zhao H, Jilka RL, Almeida M, Manolagas SC, O’Brien CA. Suppression of autophagy in osteocytes mimics skeletal aging. J Biol Chem. 2013;288:17432–40.

CAS  PubMed  PubMed Central  Google Scholar 

Nollet M, Santucci-Darmanin S, Breuil V, Al-Sahlanee R, Cros C, Topi M, Momier D, Samson M, Pagnotta S, Cailleteau L, Battaglia S, Farlay D, Dacquin R, Barois N, Jurdic P, Boivin G, Heymann D, Lafont F, Lu SS, Dempster DW, Carle GF, Pierrefite-Carle V. Autophagy in osteoblasts is involved in mineralization and bone homeostasis. Autophagy. 2014;10:1965–77.

PubMed  PubMed Central  Google Scholar 

Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S. Targeting cellular senescence prevents age-related bone loss in mice. Nat Med. 2017;23:1072–9.

CAS  PubMed  PubMed Central  Google Scholar 

Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell. 2010;140:313–26.

CAS  PubMed  PubMed Central  Google Scholar 

Sun X, Li F, Ma X, Ma J, Zhao B, Zhang Y, Li Y, Lv J, Meng X. The effects of combined treatment with naringin and treadmill exercise on osteoporosis in ovariectomized rats. Sci Rep. 2015;5:13009.

CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Guo Y, Li J, Chen YY, Liu Q, Tan L, Gao ZR, Zhang SH, Zhou YH, Feng YZ. Endoplasmic reticulum stress remodels alveolar bone formation after tooth extraction. J Cell Mol Med. 2020;24:12411–20.

CAS  PubMed  PubMed Central  Google Scholar 

The Lancet Diabetes Endocrinology. Osteoporosis: overlooked in men for too long. Lancet Diabetes Endocrinol. 2021;9:1.

PubMed  Google Scholar 

Chawalitpong S, Chokchaisiri R, Suksamrarn A, Katayama S, Mitani T, Nakamura S, Athamneh AA, Ritprajak P, Leelahavanichkul A, Aeimlapa R, Charoenphandhu N, Palaga T. Cyperenoic acid suppresses osteoclast differentiation and delays bone loss in a senile osteoporosis mouse model by inhibiting non-canonical NF-kappaB pathway. Sci Rep. 2018;8:5625.

PubMed  PubMed Central  Google Scholar 

Duque G, Troen BR. Understanding the mechanisms of senile osteoporosis: new facts for a major geriatric syndrome. J Am Geriatr Soc. 2008;56:935–41.

PubMed  Google Scholar 

Subbiah V, Madsen VS, Raymond AK, Benjamin RS, Ludwig JA. Of mice and men: divergent risks of teriparatide-induced osteosarcoma. Osteoporos Int J Establ Result Coop Between Eur Found Osteoporos Natl Osteoporos Found USA. 2010;21:1041–5.

CAS  Google Scholar 

Boquete-Castro A, Gomez-Moreno G, Calvo-Guirado JL, Aguilar-Salvatierra A, Delgado-Ruiz RA. Denosumab and osteonecrosis of the jaw. A systematic analysis of events reported in clinical trials. Clin Oral Implants Res. 2016;27:367–75.

PubMed  Google Scholar 

Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, Giacovelli G, Henrotin Y, Dacre JE, Gossett C. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001;357:251–6.

CAS  PubMed  Google Scholar 

Hu J, Chen R, Jia P, Fang Y, Liu T, Song N, Xu X, Ji J, Ding X. Augmented O-GlcNAc signaling via glucosamine attenuates oxidative stress and apoptosis following contrast-induced acute kidney injury in rats. Free Radic Biol Med. 2017;103:121–32.

CAS  PubMed  Google Scholar 

Chen YJ, Huang YS, Chen JT, Chen YH, Tai MC, Chen CL, Liang CM. Protective effects of glucosamine on oxidative-stress and ischemia/reperfusion-induced retinal injury. Investig Ophthalmol Vis Sci. 2015;56:1506–16.

CAS  Google Scholar 

Valvason C, Musacchio E, Pozzuoli A, Ramonda R, Aldegheri R, Punzi L. Influence of glucosamine sulphate on oxidative stress in human osteoarthritic chondrocytes: effects on HO-1, p22(Phox) and iNOS expression. Rheumatology. 2008;47:31–5.

CAS  PubMed  Google Scholar 

Igarashi M, Sakamoto K, Nagaoka I. Effect of glucosamine, a therapeutic agent for osteoarthritis, on osteoblastic cell differentiation. Int J Mol Med. 2011;28:373–9.

CAS  PubMed  Google Scholar 

Kumar A, Prakash A, Dogra S. Centella asiatica attenuates d-galactose-induced cognitive impairment, oxidative and mitochondrial dysfunction in mice. Int J Alzheimers Dis. 2011;2011:347569.

PubMed  PubMed Central  Google Scholar 

El-Baz FK, Saleh DO, Abdel Jaleel GA, Hussein RA, Hassan A. Heamatococcus pluvialis ameliorates bone loss in experimentally-induced osteoporosis in rats via the regulation of OPG/RANKL pathway. Biomed Pharmacother Biomed Pharmacother. 2019;116:109017.

PubMed  Google Scholar 

Yu Y, Wu J, Li J, Liu Y, Zheng X, Du M, Zhou L, Yang Y, Luo S, Hu W, Li L, Yao W, Liu Y. Cycloastragenol prevents age-related bone loss: Evidence in d-galactose-treated and aged rats. Biomed Pharmacother Biomed Pharmacother. 2020;128:110304.

CAS  PubMed  Google Scholar 

Zhang H, Wang Z, Li Y, Han J, Cui C, Lu C, Zhou J, Cheong L, Li Y, Sun T, Zhang D, Su X. Sex-based differences in gut microbiota composition in response to tuna oil and algae oil supplementation in a d-galactose-induced aging mouse model. Front Aging Neurosci. 2018;10:187.

PubMed  PubMed Central  Google Scholar 

Parzych KR, Klionsky DJ. An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal. 2014;20:460–73.