Coronary artery disease and prostate cancer share a common genetic risk mediated through Lipoprotein(a)

Abstract

The genetics underlying cancer and cardiovascular disease have been studied for decades. However, despite sharing numerous risk factors and pathologic features, the contribution of shared genetics in these diseases remains poorly defined. Our study sought to identify common genetic factors between these two diseases. We found a unique relationship between coronary artery disease and prostate cancer that appears to be mediated through germline genetic variation in LPA.

Competing Interest Statement

The authors have declared no competing interest.

Funding Statement

N.L. was supported by NIH R35 HL144475 and the American Heart Association EIA34770065. R.A.B. was supported by NIH F30 HL136188 K.T.N. is a Cancer Prevention Research Institute of Texas (CPRIT) Scholars in Cancer Research and is supported by CPRIT RR190077 and NCI K08CA263313.

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I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.

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Data Availability

GWAS summary statistics for 17 common cancers were obtained from the UK biobank (https://github.com/Wittelab/pancancer_pleiotropy) and for CAD from meta-analysis of UK Biobank SOFT CAD GWAS with the CARDIoGRAMplusC4D 1000 genomes-based GWAS and the Myocardial Infarction Genetics and CARDIoGRAM Exome(http://www.cardiogramplusc4d.org/). When prostate cancer was identified as the only cancer that correlated with CAD, prostate cancer GWAS summary statistics were obtained from the PRACTICAL consortium to increase the power for further analyses (http://practical.icr.ac.uk/blog/).

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