Borm FJ, Smit J, Oprea-Lager DE, Wondergem M, Haanen JBAG, Smit EF, et al. Response prediction and evaluation using PET in patients with solid tumors treated with immunotherapy. Cancers. 2021;13:3083.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raskov H, Orhan A, Christensen JP, Gögenur I. Cytotoxic CD8+ T cells in cancer and cancer immunotherapy. Brit J Cancer. 2021;124:359–67.

Article  CAS  PubMed  Google Scholar 

Huang Y, Park Y, Wang-Zhu Y, Larange A, Arens R, Bernardo I, et al. Mucosal memory CD8+ T cells are selected in the periphery by an MHC class I molecule. Nat Immunol. 2011;12:1086–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moebius U, Kober G, Griscelli AL, Hercend T, Meuer SC. Expression of different CD8 isoforms on distinct human lymphocyte subpopulations. Eur J Immunol. 1991;21:1793–800.

Article  CAS  PubMed  Google Scholar 

Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJM, Robert L, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature. 2014;515:568–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pandit-Taskar N, Postow MA, Hellmann MD, Harding JJ, Barker CA, O’Donoghue JA, et al. First-in-humans imaging with 89Zr-Df-IAB22M2C anti-CD8 minibody in patients with solid malignancies: preliminary pharmacokinetics, biodistribution, and lesion targeting. J Nucl Med. 2020;61:512–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ogasawara A, Kiefer JR, Gill H, Chiang E, Sriraman S, Ferl GZ, et al. Preclinical development of ZED8 an 89Zr immuno-PET reagent for monitoring tumor CD8 status in patients undergoing cancer immunotherapy. Eur J Nucl Med Mol Imaging. 2022. https://doi.org/10.1007/s00259-022-05968-6.

Kist de Ruijter L, van de Donk PP, Hooiveld-Noeken JS, Giesen D, Ungewickell A, Fine B, et al. Abstract LB037: 89ZED88082A PET imaging to visualize CD8+ T cells in patients with cancer treated with immune checkpoint inhibitor. 2021;81:LB037–LB037. https://doi.org/10.1158/1538-7445.AM2021-LB037.

Feo MSD, Pontico M, Frantellizzi V, Corica F, Cristofaro FD, Vincentis GD. 89Zr-PET imaging in humans: a systematic review. Clin Transl Imaging. 2022;10:23–36.

Article  Google Scholar 

Rashidian M, Ploegh H. Nanobodies as noninvasive imaging tools. Immuno-oncology Technol. 2020;7:2–14.

Article  CAS  Google Scholar 

Schoonooghe S, Laoui D, Ginderachter JAV, Devoogdt N, Lahoutte T, Baetselier PD, et al. Novel applications of nanobodies for in vivo bio-imaging of inflamed tissues in inflammatory diseases and cancer. Immunobiology. 2012;217:1266–72.

Article  CAS  PubMed  Google Scholar 

Abdiche YN, Yeung AY, Ni I, Stone D, Miles A, Morishige W, et al. Antibodies targeting closely adjacent or minimally overlapping epitopes can displace one another. Plos one. 2017;12:e0169535.

Article  PubMed  PubMed Central  Google Scholar 

Otwinowski Z, Minor W. [20] Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 1997;276:307–26.

Article  CAS  PubMed  Google Scholar 

McCoy AJ, Oeffner RD, Wrobel AG, Ojala JRM, Tryggvason K, Lohkamp B, et al. Ab initio solution of macromolecular crystal structures without direct methods. Proc Natl Acad Sci. 2017;114:3637–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Emsley P, Cowtan K. Coot: model-building tools for molecular graphics. Acta Crystallogr Sect D Biological Crystallogr. 2004;60:2126–32.

Article  Google Scholar 

Adams PD, Afonine PV, Bunkóczi G, Chen VB, Davis IW, Echols N, et al. PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr Sect D Biological Crystallogr. 2010;66:213–21.

Article  CAS  Google Scholar 

Genst ED, Silence K, Decanniere K, Conrath K, Loris R, Kinne J, et al. Molecular basis for the preferential cleft recognition by dromedary heavy-chain antibodies. Proc National Acad Sci. 2006;103:4586–91.

Article  Google Scholar 

Gill H, Seipert R, Carroll VM, Gouasmat A, Yin J, Ogasawara A, et al. The production, quality control, and characterization of ZED8, a CD8-specific 89Zr-labeled immuno-PET clinical imaging agent. Aaps J. 2020;22:22.

Article  CAS  PubMed  Google Scholar 

Qi J, Leahy RM. Iterative reconstruction techniques in emission computed tomography. Phys Med Biol. 2006;51:R541–78.

Article  PubMed  Google Scholar 

Wang R, Natarajan K, Margulies DH. Structural basis of the CD8αβ/MHC class I interaction: focused recognition orients CD8β to a T cell proximal position. J Immunol. 2009;183:2554–64.

Article  CAS  PubMed  Google Scholar 

Sun J, Kavathas PB. Comparison of the roles of CD8 alpha alpha and CD8 alpha beta in interaction with MHC class I. J Immunol Baltim Md. 1950;1997(159):6077–82.

Google Scholar 

Bostrom J, Lee CV, Haber L, Fuh G. Therapeutic antibodies, methods and protocols. Methods Mol Biol. 2008;525:353–76.

Article  Google Scholar 

Schneider TD, Stephens RM. Sequence logos: a new way to display consensus sequences. Nucleic Acids Res. 1990;18:6097–100.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barnett D, Storie I, Granger V, Whitby L, Reilly JT, Brough S, et al. Standardization of lymphocyte antibody binding capacity – a multi-centre study. Clin Lab Haematol. 2000;22:89–96.

Article  CAS  PubMed  Google Scholar 

Rashidian M, Ingram JR, Dougan M, Dongre A, Whang KA, LeGall C, et al. Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells. J Exp Med. 2017;214:2243–55.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muyldermans S. Nanobodies: natural single-domain antibodies. Annu Rev Biochem. 2013;82:775–97.

Article  CAS  PubMed  Google Scholar 

Ewert S, Cambillau C, Conrath K, Plückthun A. Biophysical properties of camelid VHH domains compared to those of human VH3 domains. Biochemistry-us. 2002;41:3628–36.

Article  CAS  Google Scholar 

Mitchell LS, Colwell LJ. Comparative analysis of nanobody sequence and structure data. Proteins Struct Funct Bioinform. 2018;86:697–706.

Article  CAS  Google Scholar 

Mitchell LS, Colwell LJ. Analysis of nanobody paratopes reveals greater diversity than classical antibodies. Protein Eng Des Sel. 2018;31:267–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen DS, Mellman I. Elements of cancer immunity and the cancer–immune set point. Nature. 2017;541:321–30.

Article  CAS  PubMed  Google Scholar 

Echarti A, Hecht M, Büttner-Herold M, Haderlein M, Hartmann A, Fietkau R, et al. CD8+ and regulatory T cells differentiate tumor immune phenotypes and predict survival in locally advanced head and neck cancer. Cancers. 2019;11:1398.

Article  CAS  PubMed Central  Google Scholar 

Tolmachev V, Tran TA, Rosik D, Sjöberg A, Abrahmsén L, Orlova A. Tumor targeting using affibody molecules: interplay of affinity, target expression level, and binding site composition. J Nucl Med. 2012;53:953–60.

Article  CAS  PubMed  Google Scholar 

Sörensen J, Velikyan I, Sandberg D, Wennborg A, Feldwisch J, Tolmachev V, et al. Measuring HER2-receptor expression in metastatic breast cancer using [68Ga]ABY-025 affibody PET/CT. Theranostics. 2016;6:262–71.

Article  PubMed  PubMed Central  Google Scholar 

Sanchez-Crespo A. Comparison of gallium-68 and fluorine-18 imaging characteristics in positron emission tomography. Appl Radiat Isotopes. 2013;76:55–62.

Article  CAS  Google Scholar 

Rashidian M, Keliher EJ, Bilate AM, Duarte JN, Wojtkiewicz GR, Jacobsen JT, et al. Noninvasive imaging of immune responses. P Natl Acad Sci Usa. 2015;112:6146–51.

Article  CAS  Google Scholar 

Barakat S, Berksoz M, Zahedimaram P, Piepoli S, Erman B. Nanobodies as molecular imaging probes. Free Radical Bio Med. 2022;182:260–75.

Article  CAS  Google Scholar 

Behr TM, Goldenberg DM, Becker W. Reducing the renal uptake of radiolabeled antibody fragments and peptides for diagnosis and therapy: present status, future prospects and limitations. Eur J Nucl Med. 1998;25:201–12.

Article  CAS  PubMed  Google Scholar 

Larimer BM, Wehrenberg-Klee E, Dubois F, Mehta A, Kalomeris T, Flaherty K, et al. Granzyme B PET imaging as a predictive biomarker of immunotherapy response. Cancer Res. 2017;77:2318–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roth KS, Voltin C-A, van-Heek L, Wegen S, Schomaecker K, Fischer T, et al (2022) Dual-tracer PET/CT protocol with [ 18 F]-FDG and [ 68 Ga]Ga-FAPI-46 for cancer imaging - a proof of concept. J Nucl Med. jnumed.122.263835.

Cherry SR, Jones T, Karp JS, Qi J, Moses WW, Badawi RD. Total-body PET: maximizing sensitivity to create new opportunities for clinical research and patient care. J Nucl Med. 2018;59:3–12.

Article  CAS  PubMed  PubMed Central