Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, et al. IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183: 109119.

Article  PubMed  Google Scholar 

Yazıcı D, Sezer H. Insulin resistance, obesity and lipotoxicity. Adv Exp Med Biol. 2017;960:277–304.

Article  PubMed  Google Scholar 

Unger RH, Zhou YT, Orci L. Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc Natl Acad Sci USA. 1999;96(5):2327–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meex RCR, Blaak EE, van Loon LJC. Lipotoxicity plays a key role in the development of both insulin resistance and muscle atrophy in patients with type 2 diabetes. Obes Rev. 2019;20(9):1205–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Imai Y, Cousins RS, Liu S, Phelps BM, Promes JA. Connecting pancreatic islet lipid metabolism with insulin secretion and the development of type 2 diabetes. Ann N Y Acad Sci. 2020;1461(1):53–72.

Article  CAS  PubMed  Google Scholar 

Yea K, Kim J, Yoon JH, Kwon T, Kim JH, Lee BD, et al. Lysophosphatidylcholine activates adipocyte glucose uptake and lowers blood glucose levels in murine models of diabetes. J Biol Chem. 2009;284(49):33833–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chamroonkiadtikun P, Ananchaisarp T, Wanichanon W. The triglyceride-glucose index, a predictor of type 2 diabetes development: a retrospective cohort study. Prim Care Diabetes. 2020;14(2):161–7.

Article  PubMed  Google Scholar 

Yun H, Sun L, Wu Q, Zong G, Qi Q, Li H, et al. Associations among circulating sphingolipids, beta-cell function, and risk of developing type 2 diabetes: a population-based cohort study in China. PLoS Med. 2020;17(12): e1003451.

Article  PubMed  PubMed Central  Google Scholar 

Lu J, Lam SM, Wan Q, Shi L, Huo Y, Chen L, et al. High-coverage targeted lipidomics reveals novel serum lipid predictors and lipid pathway dysregulation antecedent to type 2 diabetes onset in normoglycemic chinese adults. Diabetes Care. 2019;42(11):2117–26.

Article  CAS  PubMed  Google Scholar 

Fernandez C, Surma MA, Klose C, Gerl MJ, Ottosson F, Ericson U, et al. Plasma lipidome and prediction of type 2 diabetes in the population-based malmo diet and cancer cohort. Diabetes Care. 2020;43(2):366–73.

Article  CAS  PubMed  Google Scholar 

Razquin C, Toledo E, Clish CB, Ruiz-Canela M, Dennis C, Corella D, et al. Plasma lipidomic profiling and risk of type 2 diabetes in the PREDIMED trial. Diabetes Care. 2018;41(12):2617–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muilwijk M, Goorden SMI, Celis-Morales C, Hof MH, van der Vlugt KG, Beers-Stet FS, et al. Contributions of amino acid, acylcarnitine and sphingolipid profiles to type 2 diabetes risk among South-Asian Surinamese and Dutch adults. BMJ Open Diabetes Res Care. 2020. https://doi.org/10.1136/bmjdrc-2019-001003.

Article  PubMed  PubMed Central  Google Scholar 

Merino J, Leong A, Liu CT, Porneala B, Walford GA, von Grotthuss M, et al. Metabolomics insights into early type 2 diabetes pathogenesis and detection in individuals with normal fasting glucose. Diabetologia. 2018;61(6):1315–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rhee EP, Cheng S, Larson MG, Walford GA, Lewis GD, McCabe E, et al. Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. J Clin Invest. 2011;121(4):1402–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu Y, Wang Y, Zou L, Liang X, Ong CN, Tavintharan S, et al. Serum lipids in association with type 2 diabetes risk and prevalence in a Chinese population. J Clin Endocrinol Metab. 2018;103(2):671–80.

Article  PubMed  Google Scholar 

Chew WS, Torta F, Ji S, Choi H, Begum H, Sim X, et al. Large-scale lipidomics identifies associations between plasma sphingolipids and T2DM incidence. JCI Insight. 2019. https://doi.org/10.1172/jci.insight.126925.

Article  PubMed  PubMed Central  Google Scholar 

Sun L, Liang L, Gao X, Zhang H, Yao P, Hu Y, et al. Early prediction of developing type 2 diabetes by plasma acylcarnitines: a population-based study. Diabetes Care. 2016;39(9):1563–70.

Article  PubMed  Google Scholar 

Lu Y, Wang Y, Ong CN, Subramaniam T, Choi HW, Yuan JM, et al. Metabolic signatures and risk of type 2 diabetes in a Chinese population: an untargeted metabolomics study using both LC-MS and GC-MS. Diabetologia. 2016;59(11):2349–59.

Article  CAS  PubMed  Google Scholar 

Janus ED. Epidemiology of cardiovascular risk factors in Hong Kong. Clin Exp Pharmacol Physiol. 1997;24(12):987–8.

Article  CAS  PubMed  Google Scholar 

Lui DTW, Lee CH, Woo YC, Fong CHY, Tso AWK, Cheung BMY, et al. Cohort profile: The Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS) and the follow-up studies. Int J Epidemiol. 2021;50(4):1069-h.

Article  Google Scholar 

Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539–53.

Article  CAS  PubMed  Google Scholar 

Singh B, Saxena A. Surrogate markers of insulin resistance: a review. World J Diabetes. 2010;1(2):36–47.

Article  PubMed  PubMed Central  Google Scholar 

Halldorsson A, Magnusson CD, Haraldsson GG. Chemoenzymatic synthesis of structured triacylglycerols by highly regioselective acylation. Tetrahedron. 2003;59(46):9101–9.

Article  CAS  Google Scholar 

Matyash V, Liebisch G, Kurzchalia TV, Shevchenko A, Schwudke D. Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics. J Lipid Res. 2008;49(5):1137–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang H, Shao X, Zhao H, Li X, Wei J, Yang C, et al. Integration of metabolomics and lipidomics reveals metabolic mechanisms of triclosan-induced toxicity in human hepatocytes. Environ Sci Technol. 2019;53(9):5406–15.

Article  CAS  PubMed  Google Scholar 

Acharjee A, Larkman J, Xu Y, Cardoso VR, Gkoutos GV. A random forest based biomarker discovery and power analysis framework for diagnostics research. BMC Med Genomics. 2020;13(1):178.

Article  PubMed  PubMed Central  Google Scholar 

Pencina MJ, D’Agostino RB Sr, Steyerberg EW. Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers. Stat Med. 2011;30(1):11–21.

Article  PubMed  Google Scholar 

Yabe D, Seino Y, Fukushima M, Seino S. β cell dysfunction versus insulin resistance in the pathogenesis of type 2 diabetes in East Asians. Curr Diab Rep. 2015;15(6):602.

Article  PubMed  Google Scholar 

Qian L, Xu L, Wang X, Fu X, Gu Y, Lin F, et al. Early insulin secretion failure leads to diabetes in Chinese subjects with impaired glucose regulation. Diabetes Metab Res Rev. 2009;25(2):144–9.

Article  CAS  PubMed  Google Scholar 

Shi L, Brunius C, Lehtonen M, Auriola S, Bergdahl IA, Rolandsson O, et al. Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort. Diabetologia. 2018;61(4):849–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diamanti K, Cavalli M, Pan G, Pereira MJ, Kumar C, Skrtic S, et al. Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes. Sci Rep. 2019;9(1):9653.

Article  PubMed  PubMed Central  Google Scholar 

Yin X, Willinger CM, Keefe J, Liu J, Fernandez-Ortiz A, Ibanez B, et al. Lipidomic profiling identifies signatures of metabolic risk. EBioMedicine. 2020;51: 102520.

Article  PubMed  Google Scholar 

Meikle PJ, Wong G, Barlow CK, Weir JM, Greeve MA, MacIntosh GL, et al. Plasma lipid profiling shows similar associations with prediabetes and type 2 diabetes. PLoS ONE. 2013;8(9): e74341.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Welch EJ, Naikawadi RP, Li Z, Lin P, Ishii S, Shimizu T, et al. Opposing effects of platelet-activating factor and lyso-platelet-activating factor on neutrophil and platelet activation. Mol Pharmacol. 2009;75(1):227–34.

Article  CAS  PubMed  Google Scholar 

Iwahashi H, Okauchi Y, Ryo M, Noguchi M, Morita S, Kishida K, et al. Insulin-secretion capacity in normal glucose tolerance, impaired glucose tolerance, and diabetes in obese and non-obese Japanese patients. J Diabetes Investig. 2012;3(3):271–5.

Article  CAS  PubMed  Google Scholar 

Cen J, Sargsyan E, Bergsten P. Fatty acids stimulate insulin secretion from human pancreatic islets at fasting glucose concentra