UK Biobank’s reimaging colossus

This largest longitudinal repeat imaging study of its kind will be particularly useful for neurodegenerative disease. Serial (longitudinal) imaging in the same person typically provides better insight into disease trajectory than a single measure across a cohort (cross-sectional). It’s estimated that 6,000 to 8,000 currently healthy participants, aged 40–69 years at study onset, will develop dementia during the study. The before-and-after brain MRI images in this large population could find early, presymptomatic changes in brain structure and function.

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