Dr Audrey Elizabeth Evans, emeritus Professor of Pediatrics at the University of Pennsylvania, died peacefully at home on September 29, 2022. Like few other physicians, she helped transform what the medical establishment of the time thought impossible, curing children with cancer. On her way to do so, she shattered several glass ceilings. Audrey was passionate and undeterred when it came to doing what was right, especially for children with cancer and their families. She leaves and enormous legacy and the torch she passes on will be carried by many of her trainees, who now have become leaders in the field.