A man in his 80s’ presented with a rapidly growing lesion on his hypogastric region. Agminated small, red and translucent papules (“frog spawn” pattern) were observed [Figure 1] at the site. Koilocytes and a low-risk subtype human papillomavirus virus (HPV) infection were demonstrated in a skin biopsy. A diagnosis of condyloma acuminata was made. The lesion was excised by curettage.

Figure 1:: Grouped multiple, red and translucent small cysts-like lesions (“frog spawn” pattern) in a fold of the pubic region

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Immunosenescence and development of the lesion in a moist area might have contributed to this clinical presentation. Unusual clinical forms of anogenital warts do not seem to be related with the presence of high-risk HPV subtypes.

The differential diagnosis of “frog spawn” pattern lesions should not only include microcystic lymphatic malformation, but also condyloma, in keeping with the patient’s age.