Department of Marine Biomedicine and Polar Medicine, Naval Medical University (Second Military Medical University), Shanghai, China

Correspondence to Yang-kai Wang, Department of Marine Biomedicine and Polar Medicine, Naval Medical University, 880 Xiangyin Road, Shanghai 200433, China. E-mail: [email protected]

Abbreviations: aCSF, artificial cerebrospinal fluid; AngII, angiotensin II; BP, blood pressure; CNS, central nervous system; COX, cyclooxygenase; DMEM, Dulbecco's modified eagle medium; EAAT1, excitatory amino acid transporter1; GFP, green fluorescent protein; ICV, intracerebroventricular; KYN, kynurenic acid; pAAV, recombinant plasmids adeno-associated viral vector; PGE2, prostaglandin E2; PVN, paraventricular nucleus; RVLM, rostral ventrolateral medulla; SHR, sspontaneous hypertensive rats; SNAP25, synaptosomal-associationed protein; STAT3, signal transducer and activator of transcription 3; WKY, Wistar-Kyoto

Received 24 April, 2022

Revised 14 July, 2022

Accepted 14 July, 2022