P.J. Cimino, D.H. Gutmann, Neurofibromatosis type 1, Handbook of clinical neurology 148, 799–811 (2018) https://doi.org/10.1016/b978-0-444-64076-5.00051-x

J.M. Friedman, Epidemiology of neurofibromatosis type 1. Am. J. Med. Genet. 89, 1–6 (1999)

Article  CAS  PubMed  Google Scholar 

E. Rad, A.R. Tee, Neurofibromatosis type 1: Fundamental insights into cell signalling and cancer. Semin. Cell Dev. Biol. 52, 39–46 (2016). https://doi.org/10.1016/j.semcdb.2016.02.007

Article  CAS  PubMed  Google Scholar 

G.A. Mashour, P.H. Driever, M. Hartmann, S.N. Drissel, T. Zhang, B. Scharf, U. Felderhoff-Müser, S. Sakuma, R.E. Friedrich, R.L. Martuza, V.F. Mautner, A. Kurtz, Circulating growth factor levels are associated with tumorigenesis in neurofibromatosis type 1. Clin. cancer research: official J. Am. Association Cancer Res. 10, 5677–5683 (2004). https://doi.org/10.1158/1078-0432.Ccr-03-0769

Article  CAS  Google Scholar 

D.H. Gutmann, R.E. Ferner, R.H. Listernick, B.R. Korf, P.L. Wolters, K.J. Johnson, Neurofibromatosis type 1. Nat. Rev. Dis. Primers 3, 17004 (2017). https://doi.org/10.1038/nrdp.2017.4

Article  PubMed  Google Scholar 

T. Tucker, P. Wolkenstein, J. Revuz, J. Zeller, J.M. Friedman, Association between benign and malignant peripheral nerve sheath tumors in NF1, Neurology 65, 205–211 (2005) https://doi.org/10.1212/01.wnl.0000168830.79997.13

B.N. Somatilaka, A. Sadek, R.M. McKay, L.Q. Le, Malignant peripheral nerve sheath tumor: models, biology, and translation. Oncogene 41, 2405–2421 (2022). https://doi.org/10.1038/s41388-022-02290-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

O.O. Seminog, M.J. Goldacre, Risk of benign tumours of nervous system, and of malignant neoplasms, in people with neurofibromatosis: population-based record-linkage study. Br. J. Cancer 108, 193–198 (2013). https://doi.org/10.1038/bjc.2012.535

Article  CAS  PubMed  Google Scholar 

G. Blanchard, M.P. Lafforgue, L. Lion-François, I. Kemlin, D. Rodriguez, P. Castelnau, M. Carneiro, P. Meyer, F. Rivier, S. Barbarot, Y. Chaix, Systematic MRI in NF1 children under six years of age for the diagnosis of optic pathway gliomas. Study and outcome of a French cohort. Eur. J. Pediatr. neurology: EJPN : official J. Eur. Pediatr. Neurol. Soc. 20, 275–281 (2016). https://doi.org/10.1016/j.ejpn.2015.12.002

Article  Google Scholar 

C.J. Campen, D.H. Gutmann, Optic Pathway Gliomas in Neurofibromatosis Type 1. J. Child. Neurol. 33, 73–81 (2018). https://doi.org/10.1177/0883073817739509

Article  PubMed  PubMed Central  Google Scholar 

F. D’Angelo, M. Ceccarelli, L. Tala, J. Garofano, V. Zhang, F.P. Frattini, G. Caruso, K.D. Lewis, L. Alfaro, G. Bauchet, D. Berzero, M. Cachia, L. Cangiano, J. Capelle, F. de Groot, F. DiMeco, W. Ducray, G. Farah, S. Finocchiaro, C. Goutagny, C. Kamiya-Matsuoka, H. Lavarino, V. Loiseau, C.E. Lorgis, I. Marras, D.H. McCutcheon, S. Nam, V. Ronchi, R. Saletti, J. Seizeur, M. Slopis, F. Suñol, P. Vandenbos, D. Varlet, C. Vidaud, V. Watts, D.E. Tabar, S.K. Reuss, D. Kim, K. Meyronet, H. Mokhtari, K.P. Salvador, M. Bhat, M. Eoli, A. Sanson, Lasorella, A. Iavarone, The molecular landscape of glioma in patients with Neurofibromatosis 1. Nat. Med. 25, 176–187 (2019). https://doi.org/10.1038/s41591-018-0263-8

Article  CAS  PubMed  Google Scholar 

A.H. Zahalka, P.S. Frenette, Nerves in cancer, Nat. Rev. Cancer 20, 143–157 (2020). https://doi.org/10.1038/s41568-019-0237-2

Article  CAS  PubMed  Google Scholar 

S. Deborde, T. Omelchenko, A. Lyubchik, Y. Zhou, S. He, W.F. McNamara, N. Chernichenko, S.Y. Lee, F. Barajas, C.H. Chen, R.L. Bakst, E. Vakiani, S. He, A. Hall, R.J. Wong, Schwann cells induce cancer cell dispersion and invasion. J. Clin. Investig. 126, 1538–1554 (2016). https://doi.org/10.1172/jci82658

Article  PubMed  PubMed Central  Google Scholar 

C. Hutchings, J.A. Phillips, M.B.A. Djamgoz, Nerve input to tumours: Pathophysiological consequences of a dynamic relationship. Biochim. Biophys. Acta Rev. Cancer 1874, 188411 (2020). https://doi.org/10.1016/j.bbcan.2020.188411

Article  CAS  PubMed  Google Scholar 

H.D. Reavis, H.I. Chen, R. Drapkin, Tumor Innervation: Cancer Has Some Nerve. Trends Cancer 6, 1059–1067 (2020). https://doi.org/10.1016/j.trecan.2020.07.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

C. Magnon, S.J. Hall, J. Lin, X. Xue, L. Gerber, S.J. Freedland, P.S. Frenette, Autonomic nerve development contributes to prostate cancer progression. Sci. (New York N Y ) 341, 1236361 (2013). https://doi.org/10.1126/science.1236361

Article  Google Scholar 

H.C. Ko, V. Gupta, W.F. Mourad, K.S. Hu, L.B. Harrison, P.M. Som, R.L. Bakst, A contouring guide for head and neck cancers with perineural invasion. Pract. Radiat. Oncol. 4, e247–e258 (2014). https://doi.org/10.1016/j.prro.2014.02.001

Article  PubMed  Google Scholar 

G. Rademakers, N. Vaes, S. Schonkeren, A. Koch, K.A. Sharkey, V. Melotte, The role of enteric neurons in the development and progression of colorectal cancer, Biochim. Biophys. Acta Rev. Cancer 1868, 420–434 (2017). https://doi.org/10.1016/j.bbcan.2017.08.003

Article  CAS  PubMed  Google Scholar 

S. Faulkner, P. Jobling, B. March, C.C. Jiang, H. Hondermarck, Tumor Neurobiology and the War of Nerves in Cancer. Cancer Discov. 9, 702–710 (2019). https://doi.org/10.1158/2159-8290.Cd-18-1398

Article  CAS  PubMed  Google Scholar 

C. Jiang, R.M. McKay, L.Q. Le, Tumorigenesis in neurofibromatosis type 1: role of the microenvironment. Oncogene 40, 5781–5787 (2021). https://doi.org/10.1038/s41388-021-01979-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

N.H. Boyd, A.N. Tran, J.D. Bernstock, T. Etminan, A.B. Jones, G.Y. Gillespie, G.K. Friedman, A.B. Hjelmeland, Glioma stem cells and their roles within the hypoxic tumor microenvironment. Theranostics 11, 665–683 (2021). https://doi.org/10.7150/thno.41692

Article  CAS  PubMed  PubMed Central  Google Scholar 

Y.P. Hsueh, Neurofibromin signaling and synapses. J. Biomed. Sci. 14, 461–466 (2007). https://doi.org/10.1007/s11373-007-9158-2

Article  CAS  PubMed  Google Scholar 

A.B. Trovó-Marqui, E.H. Tajara, Neurofibromin: a general outlook. Clin. Genet. 70, 1–13 (2006). https://doi.org/10.1111/j.1399-0004.2006.00639.x

Article  PubMed  Google Scholar 

J.A. Brown, K.A. Diggs-Andrews, S.M. Gianino, D.H. Gutmann, Neurofibromatosis-1 heterozygosity impairs CNS neuronal morphology in a cAMP/PKA/ROCK-dependent manner, Mol. Cell. Neurosci. 49, 13–22 (2012) https://doi.org/10.1016/j.mcn.2011.08.008

B. Rico, H.E. Beggs, D. Schahin-Reed, N. Kimes, A. Schmidt, L.F. Reichardt, Control of axonal branching and synapse formation by focal adhesion kinase. Nat. Neurosci. 7, 1059–1069 (2004). https://doi.org/10.1038/nn1317

Article  CAS  PubMed  PubMed Central  Google Scholar 

E. Robles, T.M. Gomez, Focal adhesion kinase signaling at sites of integrin-mediated adhesion controls axon pathfinding. Nat. Neurosci. 9, 1274–1283 (2006). https://doi.org/10.1038/nn1762

Article  CAS  PubMed  Google Scholar 

M. Endo, T. Yamashita, Inactivation of Ras by p120GAP via focal adhesion kinase dephosphorylation mediates RGMa-induced growth cone collapse. J. neuroscience: official J. Soc. Neurosci. 29, 6649–6662 (2009). https://doi.org/10.1523/jneurosci.0927-09.2009

Article  CAS  Google Scholar 

S. Woo, D.J. Rowan, T.M. Gomez, Retinotopic mapping requires focal adhesion kinase-mediated regulation of growth cone adhesion. J. neuroscience: official J. Soc. Neurosci. 29, 13981–13991 (2009). https://doi.org/10.1523/jneurosci.4028-09.2009

Article  CAS  Google Scholar 

F. Kweh, M. Zheng, E. Kurenova, M. Wallace, V. Golubovskaya, W.G. Cance, Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinase. Mol. Carcinog. 48, 1005–1017 (2009). https://doi.org/10.1002/mc.20552

Article  CAS  PubMed  PubMed Central  Google Scholar 

T. Ozawa, N. Araki, S. Yunoue, H. Tokuo, L. Feng, S. Patrakitkomjorn, T. Hara, Y. Ichikawa, K. Matsumoto, K. Fujii, H. Saya, The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway. J. Biol. Chem. 280, 39524–39533 (2005). https://doi.org/10.1074/jbc.M503707200

Article  CAS  PubMed  Google Scholar 

P.I. Tsai, M. Wang, H.H. Kao, Y.J. Cheng, J.A. Walker, R.H. Chen, C.T. Chien, Neurofibromin mediates FAK signaling in confining synapse growth at Drosophila neuromuscular junctions. J. neuroscience: official J. Soc. Neurosci. 32, 16971–16981 (2012). https://doi.org/10.1523/jneurosci.1756-12.2012

Article  CAS  Google Scholar 

Y.L. Lin, Y.P. Hsueh, Neurofibromin interacts with CRMP-2 and CRMP-4 in rat brain. Biochem. Biophys. Res. Commun. 369, 747–752 (2008). https://doi.org/10.1016/j.bbrc.2008.02.095

Article  CAS  PubMed  Google Scholar 

S. Patrakitkomjorn, D. Kobayashi, T. Morikawa, M.M. Wilson, N. Tsubota, A. Irie, T. Ozawa, M. Aoki, N. Arimura, K. Kaibuchi, H. Saya, N. Araki, Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2. J. Biol. Chem. 283, 9399–9413 (2008). https://doi.org/10.1074/jbc.M708206200

Article  CAS  PubMed  Google Scholar 

M. Bergoug, M. Doudeau, F. Godin, C. Mosrin, B. Vallée, H. Bénédetti, Neurofibromin Struct. Funct. Regul. Cells 9, (2020) https://doi.org/10.3390/cells9112365

M.E. Önger, B. Delibaş, A.P. Türkmen, E. Erener, B.Z. Altunkaynak, S. Kaplan, The role of growth factors in nerve regeneration. Drug discoveries & therapeutics 10, 285–291 (2017). https://doi.org/10.5582/ddt.2016.01058

Article  CAS  Google Scholar 

K. Cichowski, S. Santiago, M. Jardim, B.W. Johnson, T. Jacks, Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor. Genes Dev. 17, 449–454 (2003). https://doi.org/10.1101/gad.1054703

Article  CAS  PubMed  PubMed Central  Google Scholar 

Y.Y. Zhang, T.A. Vik, J.W. Ryder, E.F. Srour, T. Jacks, K. Shannon, D.W. Clapp, Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines. J. Exp. Med. 187, 1893–1902 (1998). https://doi.org/10.1084/jem.187.11.1893

Article  CAS  PubMed