Design, synthesis and biological characteristics of pyrazolo[3,4-d]pyrimidine derivatives as potential VEGFR-2 inhibitors

This research was supported by the Science and Technology Program of Zhejiang Province (Key Innovative Team) under Grant no. 2018R01015, the National Natural Science Foundation of China under Grant no. 21877101, Zhejiang Provincial Natural Science Foundation of China under Grant no. LY19B020008 and the New-shoot Talents Program of Zhejiang Province under Grant No. 2022R403B082. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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