Remnant cholesterol and the risk of cardiovascular disease in type 2 diabetes: a nationwide longitudinal cohort study

Rawshani A, Rawshani A, Franzen S, Sattar N, Eliasson B, Svensson AM, Zethelius B, Miftaraj M, McGuire DK, Rosengren A, et al. Risk factors, mortality, and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2018;379(7):633–44.

Article  PubMed  Google Scholar 

Joshi PH, Martin SS, Blumenthal RS. The remnants of residual risk. J Am Coll Cardiol. 2015;65(21):2276–8.

Article  PubMed  Google Scholar 

Sandesara PB, Virani SS, Fazio S, Shapiro MD. The forgotten lipids: triglycerides, remnant cholesterol, and atherosclerotic cardiovascular disease risk. Endocr Rev. 2019;40(2):537–57.

Article  PubMed  Google Scholar 

Xiao C, Dash S, Morgantini C, Hegele RA, Lewis GF. Pharmacological targeting of the atherogenic dyslipidemia complex: the next frontier in CVD prevention beyond lowering LDL cholesterol. Diabetes. 2016;65(7):1767–78.

Article  CAS  PubMed  Google Scholar 

Nordestgaard BG, Varbo A. Triglycerides and cardiovascular disease. Lancet (London England). 2014;384(9943):626–35.

Article  CAS  Google Scholar 

Group HTC, Landray MJ, Haynes R, Hopewell JC, Parish S, Aung T, Tomson J, Wallendszus K, Craig M, Jiang L, et al. Effects of extended-release niacin with laropiprant in high-risk patients. N Engl J Med. 2014;371(3):203–12.

Article  Google Scholar 

Lincoff AM, Nicholls SJ, Riesmeyer JS, Barter PJ, Brewer HB, Fox KAA, Gibson CM, Granger C, Menon V, Montalescot G, et al. Evacetrapib and cardiovascular outcomes in high-risk vascular disease. N Engl J Med. 2017;376(20):1933–42.

Article  PubMed  Google Scholar 

Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007;298(3):299–308.

Article  CAS  PubMed  Google Scholar 

Quispe R, Martin SS, Michos ED, Lamba I, Blumenthal RS, Saeed A, Lima JAC, Puri R, Nomura SO, Tsai MY, et al: Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study. Eur Heart J 2021.

Castaner O, Pinto X, Subirana I, Amor AJ, Ros E, Hernaez A, Martinez-Gonzalez MA, Corella D, Salas-Salvado J, Estruch R, et al. Remnant cholesterol, not LDL cholesterol, is associated with incident cardiovascular disease. J Am Coll Cardiol. 2020;76(23):2712–24.

Article  CAS  PubMed  Google Scholar 

Varbo A, Benn M, Tybjaerg-Hansen A, Nordestgaard BG. Elevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease, whereas elevated low-density lipoprotein cholesterol causes ischemic heart disease without inflammation. Circulation. 2013;128(12):1298–309.

Article  CAS  PubMed  Google Scholar 

Kim HK, Song SO, Noh J, Jeong IK, Lee BW. Data configuration and publication trends for the korean national health insurance and health insurance review & assessment database. Diabetes Metab J. 2020;44(5):671–8.

Article  PubMed  PubMed Central  Google Scholar 

Kim JH, Moon JS, Byun SJ, Lee JH, Kang DR, Sung KC, Kim JY, Huh JH. Fatty liver index and development of cardiovascular disease in Koreans without pre-existing myocardial infarction and ischemic stroke: a large population-based study. Cardiovasc Diabetol. 2020;19(1):51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ko SH, Han K, Lee YH, Noh J, Park CY, Kim DJ, Jung CH, Lee KU, Ko KS. TaskForce team for the diabetes fact sheet of the korean diabetes a: past and current status of adult type 2 diabetes mellitus management in Korea: a national health insurance service database analysis. Diabetes Metab J. 2018;42(2):93–100.

Article  PubMed  PubMed Central  Google Scholar 

Ahn E, Shin DW, Yang HK, Yun JM, Chun SH, Suh B, Lee H, Son KY, Cho B. Treatment gap in the national health-screening program in Korea: claim-based follow-up of statin use for sustained hypercholesterolemia. J Korean Med Sci. 2015;30(9):1266–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim YH, Kang JG, Lee SJ, Han KD, Ihm SH, Cho KH, Park YG. Underweight increases the risk of end-stage renal diseases for type 2 diabetes in Korean population: data from the national health insurance service health checkups 2009–2017. Diabetes Care. 2020;43(5):1118–25.

Article  CAS  PubMed  Google Scholar 

Kim BY, Kang SM, Kang JH, Kang SY, Kim KK, Kim KB, Kim B, Kim SJ, Kim YH, Kim JH, et al. 2020 Korean society for the study of obesity guidelines for the management of obesity in Korea. J Obes Metab Syndr. 2021;30(2):81–92.

Article  PubMed  PubMed Central  Google Scholar 

Kim MK, Han K, Kim HS, Park YM, Kwon HS, Yoon KH, Lee SH. Cholesterol variability and the risk of mortality, myocardial infarction, and stroke: a nationwide population-based study. Eur Heart J. 2017;38(48):3560–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sone H, Nakagami T, Nishimura R, Tajima N, Group MS. Comparison of lipid parameters to predict cardiovascular events in Japanese mild-to-moderate hypercholesterolemic patients with and without type 2 diabetes: Subanalysis of the MEGA study. Diabetes Res Clin Pract. 2016;113:14–22.

Article  CAS  PubMed  Google Scholar 

Emerging Risk Factors C, Di Angelantonio E, Sarwar N, Perry P, Kaptoge S, Ray KK, Thompson A, Wood AM, Lewington S, Sattar N, et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009;302(18):1993–2000.

Article  Google Scholar 

Ye X, Kong W, Zafar MI, Chen LL. Serum triglycerides as a risk factor for cardiovascular diseases in type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies. Cardiovasc Diabetol. 2019;18(1):48.

Article  PubMed  PubMed Central  Google Scholar 

Redgrave TG, Snibson DA. Clearance of chylomicron triacylglycerol and cholesteryl ester from the plasma of streptozotocin-induced diabetic and hypercholesterolemic hypothyroid rats. Metabolism. 1977;26(5):493–503.

Article  CAS  PubMed  Google Scholar 

Proctor SD, Pabla CK, Mamo JC. Arterial intimal retention of pro-atherogenic lipoproteins in insulin deficient rabbits and rats. Atherosclerosis. 2000;149(2):315–22.

Article  CAS  PubMed  Google Scholar 

Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, Chapman MJ, De Backer GG, Delgado V, Ference BA, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020;41(1):111–88.

Article  PubMed  Google Scholar 

Johannesen CDL, Mortensen MB, Langsted A, Nordestgaard BG. Apolipoprotein B and non-HDL cholesterol better reflect residual risk than LDL cholesterol in statin-treated patients. J Am Coll Cardiol. 2021;77(11):1439–50.

Article  CAS  PubMed  Google Scholar 

Fox CS, Sullivan L, D’Agostino RB, Sr., Wilson PW, Framingham Heart S. The significant effect of diabetes duration on coronary heart disease mortality: the Framingham Heart Study. Diabetes Care. 2004;27(3):704–8.

Article  PubMed  Google Scholar 

Schaefer EJ, McNamara JR, Shah PK, Nakajima K, Cupples LA, Ordovas JM, Wilson PW, Framingham Offspring S. Elevated remnant-like particle cholesterol and triglyceride levels in diabetic men and women in the Framingham Offspring Study. Diabetes Care. 2002;25(6):989–94.

Article  CAS  PubMed  Google Scholar 

Tomono S, Kawazu S, Kato N, Ono T, Ishii C, Ito Y, Shimizu M, Shimoyama M, Nakano T, Nakajima K. Uptake of remnant like particles (RLP) in diabetic patients from mouse peritoneal macrophages. J Atheroscler Thromb. 1994;1(2):98–102.

Article  CAS  PubMed  Google Scholar 

Nordestgaard BG. Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology. Circ Res. 2016;118(4):547–63.

Article  CAS  PubMed  Google Scholar 

Cao YX, Zhang HW, Jin JL, Liu HH, Zhang Y, Gao Y, Guo YL, Wu NQ, Hua Q, Li YF, et al. The longitudinal association of remnant cholesterol with cardiovascular outcomes in patients with diabetes and pre-diabetes. Cardiovasc Diabetol. 2020;19(1):104.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim BY, Won JC, Lee JH, Kim HS, Park JH, Ha KH, Won KC, Kim DJ, Park KS. Diabetes fact sheets in Korea, 2018: An Appraisal of Current Status. Diabetes Metab J. 2019;43(4):487–94.

Article  PubMed  PubMed Central  Google Scholar 

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