Riedl MA. Critical appraisal of androgen use in hereditary angioedema: a systematic review. Ann Allergy Asthma Immunol. 2015;114(4). https://doi.org/10.1016/j.anai.2015.01.003.

Liu S, Xu Q, Xu Y, Wang X, Zhi Y. Current status of the management of hereditary angioedema in China: a patient-based, cross-sectional survey. Eur J Dermatol. 2020;30(2):169–76. https://doi.org/10.1684/ejd.2020.3758.

Article  PubMed  Google Scholar 

Santacroce R, D’Andrea G, Maffione AB, Margaglione M, d’Apolito M. The Genetics of Hereditary Angioedema: A Review. J Clin Med. 2021;10(9). https://doi.org/10.3390/jcm10092023.

Johnston DT, Henry Li H, Craig TJ, Bernstein JA, Anderson J, Joseph K, et al. Androgen use in hereditary angioedema: A critical appraisal and approaches to transitioning from androgens to other therapies. Allergy Asthma Proc. 2021;42(1):22 – 9. https://doi.org/10.2500/aap.2021.42.200106.

Nzeako UC, Frigas E, Tremaine WJ. Hereditary angioedema: a broad review for clinicians. Arch Intern Med. 2001 Nov 12;161(20):2417-29. https://doi.org/10.1001/archinte.161.20.2417.

Busse PJ, Christiansen SC. Hereditary Angioedema. N Engl J Med. 2020;382(12):1136–48. https://doi.org/10.1056/NEJMra1808012.

Article  CAS  PubMed  Google Scholar 

Patel G, Pongracic JA. Hereditary and acquired angioedema. Allergy Asthma Proc. 2019;40(6):441-5. https://doi.org/10.2500/aap.2019.40.4267.

Veronez CL, Mendes AR, Leite CS, Gomes CP, Grumach AS, Pesquero JB. The Panorama of Primary Angioedema in the Brazilian Population. J Allergy Clin Immunol Pract. 2021;9(6). https://doi.org/10.1016/j.jaip.2020.11.039.

Liu S, Xu Y, Liu Y, Zhi Y. Hereditary angioedema: a Chinese perspective. Eur J Dermatol. 2019;29(1):14–20. https://doi.org/10.1684/ejd.2018.3487.

Article  CAS  PubMed  Google Scholar 

Giavina-Bianchi P, Franca AT, Grumach AS, Motta AA, Fernandes FR, Campos RA, et al. Brazilian guidelines for the diagnosis and treatment of hereditary angioedema. Clin (Sao Paulo). 2011;66(9):1627–36. https://doi.org/10.1590/s1807-59322011000900021.

Article  Google Scholar 

Busse PJ, Christiansen SC, Riedl MA, Banerji A, Bernstein JA, Castaldo AJ, et al. US HAEA Medical Advisory Board 2020 Guidelines for the Management of Hereditary Angioedema. J Allergy Clin Immunol Pract. 2021;9(1). https://doi.org/10.1016/j.jaip.2020.08.046.

Zeerleder S, Levi M. Hereditary and acquired C1-inhibitor-dependent angioedema: from pathophysiology to treatment. Ann Med. 2016;48(4):256–67. https://doi.org/10.3109/07853890.2016.1162909.

Article  CAS  PubMed  Google Scholar 

Pappalardo E, Zingale LC, Cicardi M. Increased expression of C1-inhibitor mRNA in patients with hereditary angioedema treated with Danazol. Immunol Lett. 2003;86(3):271–6. https://doi.org/10.1016/s0165-2478(03)00029-4.

Article  CAS  PubMed  Google Scholar 

Drouet C, Désormeaux A, Robillard J, Ponard D, Bouillet L, Martin L, et al. Metallopeptidase activities in hereditary angioedema: effect of androgen prophylaxis on plasma aminopeptidase P. J Allergy Clin Immunol. 2008;121(2):429–33. https://doi.org/10.1016/s0165-2478(03)00029-4.

Article  CAS  PubMed  Google Scholar 

Gao Q, Zhang L, Zhao X, Zhu Y, Peng G, Li Y, et al. Eltrombopag, oral immunosuppressant and androgen combination therapy in twelve patients with refractory severe aplastic anemia. Hematology. 2020;25(1):341–7. https://doi.org/10.1080/16078454.2020.1815129.

Article  CAS  PubMed  Google Scholar 

Qin J, Cui N, Hou R, Liu T, Sun H, Liu Y, et al. Association between androgen receptor gene polymorphisms and testicular germ cell tumor: A systematic review and meta-analysis. J Cancer Res Ther. 2019;15(Supplement):60-S8. https://doi.org/10.4103/0973-1482.181175.

Article  CAS  Google Scholar 

Rey RA, Grinspon RP. Androgen Treatment in Adolescent Males With Hypogonadism. Am J Mens Health. 2020;14(3):1557988320922443. https://doi.org/10.1177/1557988320922443.

Article  PubMed  PubMed Central  Google Scholar 

Sheffer AL, Fearon DT, Austen KF. Methyltestosterone therapy in hereditary angioedema. Ann Intern Med. 1977;86(3):306–8. https://doi.org/10.7326/0003-4819-86-3-306.

Article  CAS  PubMed  Google Scholar 

Gelfand JA, Sherins RJ, Alling DW, Frank MM. Treatment of hereditary angioedema with danazol. Reversal of clinical and biochemical abnormalities. N Engl J Med. 1976;295(26):1444-8. http://dx.doi.org/23;295(26): 1444-8.

Bork K, Bygum A, Hardt J. Benefits and risks of danazol in hereditary angioedema: a long-term survey of 118 patients. Ann Allergy Asthma Immunol. 2008;100(2):153–61. https://doi.org/10.1016/S1081-1206(10)60424-3.

Article  CAS  PubMed  Google Scholar 

Zuraw BL, Davis DK, Castaldo AJ, Christiansen SC. Tolerability and Effectiveness of 17-α-Alkylated Androgen Therapy for Hereditary Angioedema: A Re-examination. J Allergy Clin Immunol Pract. 2016;4(5). https://doi.org/10.1016/j.jaip.2016.03.024.

Longhurst HJ, Tarzi MD, Ashworth F, Bethune C, Cale C, Dempster J, et al. C1 inhibitor deficiency: 2014 United Kingdom consensus document. Clin Exp Immunol. 2015;180(3):475–83. https://doi.org/10.1111/cei.12584.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maurer M, Magerl M. Long-term prophylaxis of hereditary angioedema with androgen derivates: a critical appraisal and potential alternatives. J Dtsch Dermatol Ges. 2011;9(2). https://doi.org/10.1111/j.1610-0387.2010.07546.x.

Cao Y, Liu S, Zhi Y. Recurrent and acute abdominal pain as the main clinical manifestation in patients with hereditary angioedema. Allergy Asthma Proc. 2021;42(2):131-5. https://doi.org/10.2500/aap.2021.42.210001.

Tse KY, Zuraw BL, Chen Q, Christiansen SC. Anabolic androgen use in the management of hereditary angioedema: Not so cheap after all. Ann Allergy Asthma Immunol. 2017;118(4). https://doi.org/10.1016/j.anai.2017.01.015.

Zotter Z, Veszeli N, Csuka D, et al. Frequency of the virilising effects of attenuated androgens reported by women with hereditary angioedema. Orphanet J Rare Dis. 2014;9:205. https://doi.org/10.1186/s13023-014-0205-6.

Article  PubMed  PubMed Central  Google Scholar 

Bouillet L, Longhurst H, Boccon-Gibod I, et al. Disease expression in women with hereditary angioedema. Am J Obstet Gynecol. 2008;199(5):484.e1-.e4. https://doi.org/10.1016/j.ajog.2008.04.034.

Article  PubMed  Google Scholar 

Caballero T, Farkas H, Bouillet L, et al. International consensus and practical guidelines on the gynecologic and obstetric management of female patients with hereditary angioedema caused by C1 inhibitor deficiency. J Allergy Clin Immunol. 2012;129(2):308–20. https://doi.org/10.1016/j.jaci.2011.11.025.

Article  PubMed  Google Scholar 

Sheffer AL, Fearon DT, Austen KF. Clinical and biochemical effects of stanozolol therapy for hereditary angioedema. J Allergy Clin Immunol. 1981;68(3):181–7. https://doi.org/10.1016/0091-6749(81)90181-0.

Article  CAS  PubMed  Google Scholar 

Zurlo JJ, Frank MM. The long-term safety of danazol in women with hereditary angioedema. Fertil Steril. 1990;54(1):64–72. https://doi.org/10.1016/s0015-0282(16)53638-3.

Article  CAS  PubMed  Google Scholar 

Hosea SW, Santaella ML, Brown EJ, et al. Long-term therapy of hereditary angioedema with danazol. Ann Intern Med. 1980;93(6):809–12. https://doi.org/10.1055/s-2008-1064982.

Article  CAS  PubMed  Google Scholar 

Bienenfeld A, Azarchi S, Lo Sicco K, et al. Androgens in women: Androgen-mediated skin disease and patient evaluation. J Am Acad Dermatol. 2019;80(6):1497–506. https://doi.org/10.1016/j.jaad.2018.08.062.

Article  CAS  PubMed  Google Scholar 

Lello S, Primavera G, Colonna L, et al. Effects of two estroprogestins containing ethynilestradiol 30 microg and drospirenone 3 mg and ethynilestradiol 30 microg and chlormadinone 2 mg on skin and hormonal hyperandrogenic manifestations. Gynecol Endocrinol. 2008;24(12):718–23. https://doi.org/10.1080/09513590802454943.

Article  CAS  PubMed  Google Scholar 

Elsenbruch S, Hahn S, Kowalsky D, et al. Quality of life, psychosocial well-being, and sexual satisfaction in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2003;88(12):5801–7. https://doi.org/10.1210/jc.2003-030562.

Article  CAS  PubMed  Google Scholar 

Westaby D, Ogle SJ, Paradinas FJ, et al. Liver damage from long-term methyltestosterone. Lancet. 1977;2(8032):262-3. http://dx.doi.org/6;2(8032): 262-3.

Balasch J, Martinez-Román S, Carreras J, et al. Acute pancreatitis associated with danazol treatment for endometriosis. Hum Reprod. 1994;9(6):1163–5. https://doi.org/10.1093/oxfordjournals.humrep.a138651.

Article  CAS  PubMed  Google Scholar 

Bork K, Schneiders V. Danazol-induced hepatocellular adenoma in patients with hereditary angio-oedema. J Hepatol. 2002;36(5):707–9. https://doi.org/10.1016/s0168-8278(02)00035-1.

Article  PubMed  Google Scholar 

Cicardi M, Bergamaschini L, Tucci A, et al. Morphologic evaluation of the liver in hereditary angioedema patients on long-term treatment with androgen derivatives. J Allergy Clin Immunol. 1983;72(3):294–8. https://doi.org/10.1016/0091-6749(83)90034-9.

Article  CAS  PubMed  Google Scholar 

Giannitrapani L, Soresi M, La Spada E, et al. Sex hormones and risk of liver tumor. Ann N Y Acad Sci. 2006;1089:228–36. https://doi.org/10.1196/annals.1386.044.

Article  CAS  PubMed  Google Scholar 

Helsing P, Nielsen EW. Hepatocellular focal nodular hyperplasia after danazol treatment for hereditary angio-oedema. Acta Derm Venereol. 2006;86(3):272–3. https://doi.org/10.2340/00015555-0057.

Article  PubMed  Google Scholar 

Corfield EC, Martin NG, Nyholt DR. Co-occurrence and symptomatology of fatigue and depression. Compr Psychiatry 2016;71. https://doi.org/10.1016/j.comppsych.2016.08.004.

Andriole GL, Brickman C, Lack EE, et al. Danazol-induced cystitis: an undescribed source of hematuria in patients with hereditary angioneurotic edema. J Urol. 1986;135(1):44–6. https://doi.org/10.1016/s0022-5347(17)45509-1.

Article  CAS  PubMed  Google Scholar 

Rosado-Quiñones AM, Zaragoza-Urdaz R. Hereditary Angioedema: An Updated Experience with Patients with Angioedema in Puerto Rico. P R Health Sci J. 2019;38(4):248–54. http://dx.doi.org/38. 4 : 248–254.

PubMed  Google Scholar 

Birjmohun RS, Kees Hovingh G, Stroes ESG, et al. Effects of short-term and long-term danazol treatment on lipoproteins, coagulation, and progression of atherosclerosis: two clinical trials in healthy volunteers and patients with hereditary angioedema. Clin Ther. 2008;30(12):2314–23. https://doi.org/10.1016/j.clinthera.2008.12.021.

Article  CAS  PubMed  Google Scholar 

Széplaki G, Varga L, Valentin S, et al. Adverse effects of danazol prophylaxis on the lipid profiles of patients with hereditary angioedema. J Allergy Clin Immunol. 2005;115(4):864–9. https://doi.org/10.1016/j.jaci.2004.12.1130.

Article  CAS  PubMed  Google Scholar 

Hartgens F, Kuipers H. Effects of androgenic-anabolic steroids in athletes. Sports Med. 2004;34(8):513–54. https://doi.org/10.2165/00007256-200434080-00003.

Article  PubMed  Google Scholar 

van Amsterdam J, Opperhuizen A, Hartgens F. Adverse health effects of anabolic-androgenic steroids. Regul Toxicol Pharmacol. 2010;57(1):117–23. https://doi.org/10.1016/j.yrtph.2010.02.001.

Article