Horm Metab Res
DOI: 10.1055/a-1954-5605
1 school of medicine, Bam University of Medical Sciences, Bam, Iran (the Islamic Republic of) (Ringgold ID: RIN394237)
,
Mohammad Moein Derakhshan
2 Student Research committee, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran (the Islamic Republic of) (Ringgold ID: RIN48516)
,
mohadese razmjooie
3 nursing school, Islamic Azad University of Darab, darab, Iran (the Islamic Republic of)
,
fateme zare
4 Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran (the Islamic Republic of) (Ringgold ID: RIN48516)
,
habibe Amiresmaeili
5 Nursing research center, Kerman University of Medical Sciences, Kerman, Iran (the Islamic Republic of) (Ringgold ID: RIN48463)
,
negin salehi
6 School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran (the Islamic Republic of) (Ringgold ID: RIN48455)
,
negar namakkoobi
7 Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran (the Islamic Republic of) (Ringgold ID: RIN113396)
,
hamid mirhosseini
8 Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran (the Islamic Republic of) (Ringgold ID: RIN48516)
,
bardia karim
9 Student Research Committee, Babol University of Medical Science, Babol, Iran (the Islamic Republic of) (Ringgold ID: RIN114456)
,
sima iravani
10 School of Paramedical Sciences, Yazd University of Medical Science, Yazd, Iran (the Islamic Republic of) (Ringgold ID: RIN48516)
› Author Affiliations › Further Information Also available at PDF Download Buy Article Permissions and ReprintsBackground and Aim: by the end of December 2019 new corona virus began to spread from Wuhan, China and caused a worldwide pandemic. COVID-19 deaths and prevalence represented sex discrepant patterns with higher rate of deaths and infection in males than females which could be justified by androgen-mediated mechanisms. this review aimed to assess the role of androgens in COVID-19 severity and mortality Discussion: androgens increase expression of Type II transmembrane Serine Protease (TMPRSS2) and Angiotensin Converting Enzyme 2 (ACE2) which both facilitate new corona virus entry into host cell and their expression is higher in young males than females. According to observational studies, prevalence of COVID-19 infections and deaths was more in androgenic alopecic patients than patients without androgenic alopecia. The COVID-19 mortality rates in aged men (>60 years) was substantially higher than aged females and even young males caused by high inflammatory activities such as cytokine storm due to hypogonadism in this population. Use of anti-androgen and TMPRSS2 inhibitor drugs considerably modified COVID-19 symptoms. androgen deprivation therapy also improved COVID-19 symptoms in prostate cancer: overall the role of androgens in severity of COVID-19 and its associated mortality seemed to be very important . So more studies in variety of populations are required to define the absolute role of androgens.
Publication HistoryReceived: 20 December 2021
Accepted after revision: 04 October 2022
Accepted Manuscript online:
04 October 2022
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