Horm Metab Res
DOI: 10.1055/a-1954-5605

1   school of medicine, Bam University of Medical Sciences, Bam, Iran (the Islamic Republic of) (Ringgold ID: RIN394237)

,

Mohammad Moein Derakhshan

2   Student Research committee, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran (the Islamic Republic of) (Ringgold ID: RIN48516)

,

mohadese razmjooie

3   nursing school, Islamic Azad University of Darab, darab, Iran (the Islamic Republic of)

,

fateme zare

4   Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran (the Islamic Republic of) (Ringgold ID: RIN48516)

,

habibe Amiresmaeili

5   Nursing research center, Kerman University of Medical Sciences, Kerman, Iran (the Islamic Republic of) (Ringgold ID: RIN48463)

,

negin salehi

6   School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran (the Islamic Republic of) (Ringgold ID: RIN48455)

,

negar namakkoobi

7   Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran (the Islamic Republic of) (Ringgold ID: RIN113396)

,

hamid mirhosseini

8   Research Center of Addiction and Behavioral Sciences, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran (the Islamic Republic of) (Ringgold ID: RIN48516)

,

bardia karim

9   Student Research Committee, Babol University of Medical Science, Babol, Iran (the Islamic Republic of) (Ringgold ID: RIN114456)

,

sima iravani

10   School of Paramedical Sciences, Yazd University of Medical Science, Yazd, Iran (the Islamic Republic of) (Ringgold ID: RIN48516)

Background and Aim: by the end of December 2019 new corona virus began to spread from Wuhan, China and caused a worldwide pandemic. COVID-19 deaths and prevalence represented sex discrepant patterns with higher rate of deaths and infection in males than females which could be justified by androgen-mediated mechanisms. this review aimed to assess the role of androgens in COVID-19 severity and mortality Discussion: androgens increase expression of Type II transmembrane Serine Protease (TMPRSS2) and Angiotensin Converting Enzyme 2 (ACE2) which both facilitate new corona virus entry into host cell and their expression is higher in young males than females. According to observational studies, prevalence of COVID-19 infections and deaths was more in androgenic alopecic patients than patients without androgenic alopecia. The COVID-19 mortality rates in aged men (>60 years) was substantially higher than aged females and even young males caused by high inflammatory activities such as cytokine storm due to hypogonadism in this population. Use of anti-androgen and TMPRSS2 inhibitor drugs considerably modified COVID-19 symptoms. androgen deprivation therapy also improved COVID-19 symptoms in prostate cancer: overall the role of androgens in severity of COVID-19 and its associated mortality seemed to be very important . So more studies in variety of populations are required to define the absolute role of androgens.

Received: 20 December 2021

Accepted after revision: 04 October 2022

Accepted Manuscript online:
04 October 2022

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