Glucose-responsive nanoparticles designed via a molecular-docking-driven method for insulin delivery
Keywords
Diabetes
Insulin delivery
Glucose-responsive nanoparticles
Anti-hypoglycemia properties
Molecular docking
Abbreviation listGRIDS
Glucose-responsive insulin delivery system
FITC-INS
Fluorescein-isothiocyanate-labeled insulin
PBS
Phosphate buffered saline
ELISA
Enzyme linked immunosorbent assay
FPBA
4-Carboxy-3-fluorophenylboronic acid
EDC
1-Ethyl-3-(3-dimethylamino propyl)-carbodiimide hydrochloride
Cn/FPBA-g-PL
Fatty-acid/4-carboxy −3-fluorophenylboronic-acid-g-ε-polylysine
CnPL
Cn(10%)-g-PL (n = 4–12, 10% represented the graft ratio of Cn)
CnMS
Cn(10%)/FPBA(48%)-g-PL (n = 4–12, 10% and 48% represented the graft ratio of Cn and FPBA, respectively)
MACn
Methyl-amidated Cn (n = 2–18)
RBA
Relative bioavailability
MCV
Mean corpuscular volume
FRET
Förster resonance energy transfer
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