Dementia risk variants — hunting needles in a haystack

Ertekin-Taner, N. Gene expression endophenotypes: a novel approach for gene discovery in Alzheimer’s disease. Mol. Neurodegener. 6, 31 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zou, F. et al. Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. PLoS Genet. 8, e1002707 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Allen, M. et al. Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci. Acta Neuropathol. 132, 197–211 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sieberts, S. K. et al. Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions. Sci. Data 7, 340 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ertekin-Taner, N., De Jager, P. L., Yu, L. & Bennett, D. A. Alternative approaches in gene discovery and characterization in Alzheimer’s disease. Curr. Genet. Med. Rep. 1, 39–51 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Allen, M. et al. Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy. Acta Neuropathol. 136, 709–727 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wan, Y.-W. et al. Meta-analysis of the Alzheimer’s disease human brain transcriptome and functional dissection in mouse models. Cell Rep. 32, 107908 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, X. et al. Alzheimer’s disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions. J. Clin. Invest. 132, e149904 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Allen, M. et al. Conserved brain myelination networks are altered in Alzheimer’s and other neurodegenerative diseases. Alzheimers Dement. 14, 352–366 (2018).

Article  PubMed  Google Scholar 

Cooper, Y. A. et al. Functional regulatory variants implicate distinct transcriptional networks in dementia. Science 377, eabi8654 (2022).

Article  CAS  PubMed  Google Scholar 

留言 (0)

沒有登入
gif