Synchronous Whole Sternal Metastasis from Primary Malignant Mediastinal Germ Cell Tumor in a Teenager

CC BY-NC-ND 4.0 · South Asian J Cancer
DOI: 10.1055/s-0042-1757426

Vasudeva K. Bhat

1   Division of Pediatric Hematology and Oncology, Manipal Comprehensive Cancer Care Center, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India

,

1   Division of Pediatric Hematology and Oncology, Manipal Comprehensive Cancer Care Center, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India

,

Nawaz Usman

2   Department of Surgical Oncology, Manipal Comprehensive Cancer Care Center, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India

,

2   Department of Surgical Oncology, Manipal Comprehensive Cancer Care Center, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India

› Author Affiliations Funding This study did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
  SFX Search  Permissions and Reprints Abstract Naveena A.N. Kumar

Primary malignant germ cell tumor (GCT) of the mediastinum is a rare entity with an incidence ranging from 1 to 2% of all childhood cancers. Though a few cases of bone metastasis from mediastinal GCTs have been reported, synchronous whole sternal metastasis from primary malignant mediastinal GCTs is very rare. We report such a rare manifestation in a teenager, emphasizing the need for a multidisciplinary treatment approach with neoadjuvant chemotherapy, surgical expertise for en bloc excision of the mediastinal mass along with whole sternal resection, and reconstruction in a dedicated cancer care center for better oncological outcomes.

Keywords malignant mediastinal germ cell tumor - sternal metastasis - sternal resection and reconstruction - childhood cancer Ethics Approval

The institutional research committee has confirmed that no ethical approval is required.


Note

Written informed consent was obtained from the patient for participation in the study and for publication of their clinical details and images.

Publication History

Article published online:
02 November 2022

© 2022. MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

Thieme Medical and Scientific Publishers Pvt. Ltd.
A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

 
References 1 Yalçın B, Demir HA, Tanyel FC. et al. Mediastinal germ cell tumors in childhood. Pediatr Hematol Oncol 2012; 29 (07) 633-642 2 Oing C, Oechsle K, Necchi A. et al. Impact of primary metastatic bone disease in germ cell tumors: results of an International Global Germ Cell Tumor Collaborative Group G3 Registry Study. Ann Oncol 2017; 28 (03) 576-582 3 Grabski DF, Pappo AS, Krasin MJ, Davidoff AM, Rao BN, Fernandez-Pineda I. Long-term outcomes of pediatric and adolescent mediastinal germ cell tumors: a single pediatric oncology institutional experience. Pediatr Surg Int 2017; 33 (02) 235-244 4 Chapelier AR, Missana MC, Couturaud B. et al. Sternal resection and reconstruction for primary malignant tumors. Ann Thorac Surg 2004; 77 (03) 1001-1006 , discussion 1006–1007 5 Incarbone M, Nava M, Lequaglie C, Ravasi G, Pastorino U. Sternal resection for primary or secondary tumors. J Thorac Cardiovasc Surg 1997; 114 (01) 93-99
 

留言 (0)

沒有登入
gif