Agarwalla A, Liu JN, Garcia GH, Gowd AK, Puzzitiello RN, Yanke AB et al (2020) Return to sport following isolated lateral opening wedge distal femoral osteotomy. Cartilage. https://doi.org/10.1177/19476035209247751947603520924775

Article  PubMed  PubMed Central  Google Scholar 

Alford JW, Cole BJ (2005) Cartilage restoration, part 1: basic science, historical perspective, patient evaluation, and treatment options. Am J Sports Med 33:295–306

PubMed  Google Scholar 

Ball LM, Bernardo ME, Locatelli F, Egeler RM (2008) Potential role of mesenchymal stromal cells in pediatric hematopoietic SCT. Bone Marrow Transplant 42(Suppl 2):S60-66

CAS  PubMed  Google Scholar 

Barie A, Kruck P, Sorbi R, Rehnitz C, Oberle D, Walker T et al (2020) Prospective long-term follow-up of autologous chondrocyte implantation with periosteum versus matrix-associated autologous chondrocyte implantation: a randomized clinical trial. Am J Sports Med 48:2230–2241

PubMed  Google Scholar 

Basad E, Wissing FR, Fehrenbach P, Rickert M, Steinmeyer J, Ishaque B (2015) Matrix-induced autologous chondrocyte implantation (MACI) in the knee: clinical outcomes and challenges. Knee Surg Sports Traumatol Arthrosc 23:3729–3735

PubMed  Google Scholar 

Behrens P (2005) Matrixgekoppelte Mikrofrakturierung. Arthroskopie 18:193–197

Google Scholar 

Bertho P, Pauvert A, Pouderoux T, Robert H, Orthopaedics, Traumatology Society of Western F (2018) Treatment of large deep osteochondritis lesions of the knee by autologous matrix-induced chondrogenesis (AMIC): preliminary results in 13 patients. Orthop Traumatol Surg Res 104:695–700

PubMed  Google Scholar 

Briggs KK, Lysholm J, Tegner Y, Rodkey WG, Kocher MS, Steadman JR (2009) The reliability, validity, and responsiveness of the Lysholm score and Tegner activity scale for anterior cruciate ligament injuries of the knee: 25 years later. Am J Sports Med 37:890–897

PubMed  Google Scholar 

Brittberg M (2022) Knee osteochondritis dissecans-treatment technical aspects. J Orthop 34:104–110

PubMed  Google Scholar 

Brittberg M, Recker D, Ilgenfritz J, Saris DBF, Group SES (2018) Matrix-applied characterized autologous cultured chondrocytes versus microfracture: five-year follow-up of a prospective randomized trial. Am J Sports Med 46:1343–1351

PubMed  Google Scholar 

Collins NJ, Misra D, Felson DT, Crossley KM, Roos EM (2011) Measures of knee function: international knee documentation committee (IKDC) subjective knee evaluation form, knee injury and osteoarthritis outcome score (KOOS), knee injury and osteoarthritis outcome score physical function short form (KOOS-PS), knee outcome survey activities of daily living scale (KOS-ADL), Lysholm Knee Scoring Scale, Oxford Knee Score (OKS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), activity rating scale (ARS), and tegner activity score (TAS). Arthritis Care Res (Hoboken) 63(Suppl 11):S208-228

Google Scholar 

Cvetanovich GL, Riboh JC, Tilton AK, Cole BJ (2017) Autologous chondrocyte implantation improves knee-specific functional outcomes and health-related quality of life in adolescent patients. Am J Sports Med 45:70–76

PubMed  Google Scholar 

Dai XS, Cai YZ (2012) Matrix-induced autologous chondrocyte implantation addressing focal chondral defect in adolescent knee. Chin Med J (Engl) 125:4130–4133

Google Scholar 

de Girolamo L, Schonhuber H, Vigano M, Bait C, Quaglia A, Thiebat G et al (2019) Autologous matrix-induced chondrogenesis (AMIC) and AMIC enhanced by autologous concentrated bone marrow aspirate (BMAC) allow for stable clinical and functional improvements at up to 9 years follow-up: results from a randomized controlled study. J Clin Med 8:392

PubMed Central  Google Scholar 

Giuliani N, Lisignoli G, Magnani M, Racano C, Bolzoni M, Dalla Palma B et al (2013) New insights into osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells and their potential clinical applications for bone regeneration in pediatric orthopaedics. Stem Cells Int 2013:312501

PubMed  PubMed Central  Google Scholar 

Gotze C, Nieder C, Felder H, Migliorini F (2020) AMIC for focal osteochondral defect of the talar shoulder. Life (Basel) 10:328

Google Scholar 

Grevenstein D, Schafigh D, Oikonomidis S, Eysel P, Brochhausen C, Spies CK et al (2021) Short-term radiological results after spheroid-based autologous chondrocyte implantation in the knee are independent of defect localisation. Technol Health Care. https://doi.org/10.3233/THC-213066

Article  Google Scholar 

Grimm NL, Weiss JM, Kessler JI, Aoki SK (2014) Osteochondritis dissecans of the knee: pathoanatomy, epidemiology, and diagnosis. Clin Sports Med 33:181–188

PubMed  Google Scholar 

Hoburg A, Loer I, Korsmeier K, Siebold R, Niemeyer P, Fickert S et al (2019) Matrix-associated autologous chondrocyte implantation is an effective treatment at midterm follow-up in adolescents and young adults. Orthop J Sports Med 7:2325967119841077

PubMed  PubMed Central  Google Scholar 

Howick J CI, Glasziou P, Greenhalgh T, Carl Heneghan, Liberati A, Moschetti I, Phillips B, Thornton H, Goddard O, Hodgkinson M (2011) The 2011 Oxford CEBM levels of evidence. Oxford centre for evidence-based medicine. Available at https://www.cebm.net/index.aspx?o=5653. Accessed on Oct 2020

Hunziker EB, Stahli A (2008) Surgical suturing of articular cartilage induces osteoarthritis-like changes. Osteoarthritis Cartilage 16:1067–1073

CAS  PubMed  PubMed Central  Google Scholar 

Irrgang JJ, Anderson AF, Boland AL, Harner CD, Kurosaka M, Neyret P et al (2001) Development and validation of the international knee documentation committee subjective knee form. Am J Sports Med 29:600–613

CAS  PubMed  Google Scholar 

Iversen MD, von Heideken J, Farmer E, Rihm J, Heyworth BE, Kocher MS (2016) Validity and comprehensibility of physical activity scales for children with sport injuries. J Pediatr Orthop 36:278–283

PubMed  Google Scholar 

Jones KJ, Kelley BV, Arshi A, McAllister DR, Fabricant PD (2019) Comparative effectiveness of cartilage repair with respect to the minimal clinically important difference. Am J Sports Med 47:3284–3293

PubMed  Google Scholar 

Kaszkin-Bettag M (2013) Is autologous chondrocyte implantation (ACI) an adequate treatment option for repair of cartilage defects in paediatric patients? Drug Discov Today 18:740–747

PubMed  Google Scholar 

Kocher MS, Smith JT, Iversen MD, Brustowicz K, Ogunwole O, Andersen J et al (2011) Reliability, validity, and responsiveness of a modified international knee documentation committee subjective knee form (Pedi-IKDC) in children with knee disorders. Am J Sports Med 39:933–939

PubMed  Google Scholar 

Kreuz PC, Steinwachs M, Erggelet C, Krause SJ, Ossendorf C, Maier D et al (2007) Classification of graft hypertrophy after autologous chondrocyte implantation of full-thickness chondral defects in the knee. Osteoarthritis Cartilage 15:1339–1347

CAS  PubMed  Google Scholar 

Kubota M, Ishijima M, Ikeda H, Takazawa Y, Saita Y, Kaneko H et al (2018) Mid and long term outcomes after fixation of osteochondritis dissecans. J Orthop 15:536–539

PubMed  PubMed Central  Google Scholar 

Macmull S, Parratt MT, Bentley G, Skinner JA, Carrington RW, Morris T et al (2011) Autologous chondrocyte implantation in the adolescent knee. Am J Sports Med 39:1723–1730

PubMed  Google Scholar 

Micheli L, Curtis C, Shervin N (2006) Articular cartilage repair in the adolescent athlete: is autologous chondrocyte implantation the answer? Clin J Sport Med 16:465–470

PubMed  Google Scholar 

Migliorini F, Berton A, Salvatore G, Candela V, Khan W, Longo UG et al (2020) Autologous chondrocyte implantation and mesenchymal stem cells for the treatments of chondral defects of the knee- a systematic review. Curr Stem Cell Res Ther 15:547–556

CAS  PubMed  Google Scholar 

Migliorini F, Berton A, Salvatore G, Candela V, Khan W, Longo UG et al (2020) Autologous chondrocyte implantation and mesenchymal stem cells for the treatments of chondral defects of the knee- a systematic review. Curr Stem Cell Res Ther. https://doi.org/10.2174/1574888X15666200221122834

Article  PubMed  Google Scholar 

Migliorini F, Eschweiler J, Goetze C, Tingart M, Maffulli N (2021) Membrane scaffolds for matrix-induced autologous chondrocyte implantation in the knee: a systematic review. Br Med Bull 140:50–61

CAS  PubMed  Google Scholar 

Migliorini F, Eschweiler J, Gotze C, Driessen A, Tingart M, Maffulli N (2022) Matrix-induced autologous chondrocyte implantation (mACI) versus autologous matrix-induced chondrogenesis (AMIC) for chondral defects of the knee: a systematic review. Br Med Bull. https://doi.org/10.1093/bmb/ldac004

Article  PubMed  PubMed Central  Google Scholar 

Migliorini F, Eschweiler J, Maffulli N, Driessen A, Rath B, Tingart M et al (2021) Management of patellar chondral defects with autologous matrix induced chondrogenesis (AMIC) compared to microfractures: a four years follow-up clinical trial. Life (Basel) 11:141

Google Scholar 

Migliorini F, Eschweiler J, Maffulli N, Schenker H, Baroncini A, Tingart M et al (2021) Autologous matrix-induced chondrogenesis (AMIC) and microfractures for focal chondral defects of the knee: a medium-term comparative study. Life (Basel) 11:183

Google Scholar 

Migliorini F, Eschweiler J, Maffulli N, Schenker H, Driessen A, Rath B et al (2021) Autologous matrix induced chondrogenesis (AMIC) compared to microfractures for chondral defects of the talar shoulder: a five-year follow-up prospective cohort study. Life (Basel) 11:224

Google Scholar 

Migliorini F, Eschweiler J, Schenker H, Baroncini A, Tingart M, Maffulli N (2021) Surgical management of focal chondral defects of the knee: a Bayesian network meta-analysis. J Orthop Surg Res 16:543

PubMed  PubMed Central  Google Scholar 

Migliorini F, Eschweiler J, Spiezia F, van de Wall BJM, Knobe M, Tingart M et al (2021) Arthroscopy versus mini-arthrotomy approach for matrix-induced autologous chondrocyte implantation in the knee: a systematic review. J Orthop Traumatol 22:23

PubMed  PubMed Central  Google Scholar 

Migliorini F, Maffulli N (2021) Arthroscopic management of femoroacetabular impingement in adolescents: a systematic review. Am J Sports Med 49:3708–3715

PubMed  Google Scholar 

Migliorini F, Maffulli N, Baroncini A, Knobe M, Tingart M, Eschweiler J (2021) Matrix-induced autologous chondrocyte implantation versus autologous matrix-induced chondrogenesis for chondral defects of the talus: a systematic review. Br Med Bull 138:144–154

PubMed  Google Scholar 

Migliorini F, Pilone M, Eschweiler J, Marsilio E, Hildebrand F, Maffulli N (2022) High rates of damage to the medial patellofemoral ligament, lateral trochlea and patellar crest after acute patellar dislocation: MRI analysis. Arthroscopy. https://doi.org/10.1016/j.arthro.2022.01.044

Article  PubMed  Google Scholar 

Migliorini F, Prinz J, Maffulli N, Eschweiler J, Weber C, Lecoutrier S et al (2022) Fibrin glue does not assist migration and proliferation of chondrocytes in collagenic membranes: an in vitro study. J Orthop Surg Res 17:311

PubMed  PubMed Central  Google Scholar 

Mithoefer K, Saris DB, Farr J, Kon E, Zaslav K, Cole BJ et al (2011) Guidelines for the design and conduct of clinical studies in knee articular cartilage repair: international cartilage repair society recommendations based on current scientific evidence and standards of clinical care. Cartilage 2:100–121

PubMed  PubMed Central  Google Scholar 

Mithofer K, Minas T, Peterson L, Yeon H, Micheli LJ (2005) Functional outcome of knee articular cartilage repair in adolescent athletes. Am J Sports Med 33:1147–1153

PubMed  Google Scholar 

Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 339:b2535