Ethics approval and consent to participate

The research is approved by IRB (CNUH2018-08-013-012) of Chungnam National University Hospital. The AML/ALL patients samples were obtained with patients informed consent. All experiments were conducted as per the declaration of Helsinki. For the mouse experiments, all animals (6 ~ 8 weeks old) were housed under a specific pathogen-free environment, and all the in vivo experiments were reviewed and approved by Institutional Animal Care and Use Committee, CNU School of Medicine, Daejeon, Korea (CNUH-020-A0054).

Consent for publication

All authors approved and directly participated in the planning, execution and/or analysis of the data presented in this study. The content of this manuscript has not been previously published and is not under consideration for publication elsewhere.

Competing interests

S.Y., Y.Z., N.L., and J.Z. are employees of Sema4, a for-profit organization that promotes personalized patient care through information-driven insights. Other authors declare that they have no competing interests.