Himalian R, Singh SK, Singh MP (2022) Ameliorative role of nutraceuticals on neurodegenerative diseases using the Drosophila melanogaster as a discovery model to define bioefficacy. J Am Nutr Assoc 41(5):511–539. https://doi.org/10.1080/07315724.2021.1904305
Article CAS PubMed Google Scholar
Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease. Neurology 42(3 Pt 1):631–639. https://doi.org/10.1212/wnl.42.3.631
Article CAS PubMed Google Scholar
Braak H, Del Tredici K, Rub U, de Vos RA, Jansen Steur EN, Braak E (2003) Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging 24(2):197–211. https://doi.org/10.1016/s0197-4580(02)00065-9
Coyne AN, Zaepfel BL, Zarnescu DC (2017) Failure to deliver and translate-new insights into RNA dysregulation in ALS. Front Cell Neurosci 11:243. https://doi.org/10.3389/fncel.2017.00243
Article CAS PubMed PubMed Central Google Scholar
DeVos SL, Miller RL, Schoch KM, Holmes BB, Kebodeaux CS, Wegener AJ, Chen G, Shen T et al. (2017) Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy. Sci Transl Med 9 (374). https://doi.org/10.1126/scitranslmed.aag0481
Kritsilis M, S VR, Koutsoudaki PN, Evangelou K, Gorgoulis VG, Papadopoulos D (2018) Ageing, cellular senescence and neurodegenerative disease. Int J Mol Sci 19 (10). https://doi.org/10.3390/ijms19102937
Aleksis R, Oleskovs F, Jaudzems K, Pahnke J, Biverstal H (2017) Structural studies of amyloid-beta peptides: unlocking the mechanism of aggregation and the associated toxicity. Biochimie 140:176–192. https://doi.org/10.1016/j.biochi.2017.07.011
Article CAS PubMed Google Scholar
Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer’s disease. Neuron 3(4):519–526. https://doi.org/10.1016/0896-6273(89)90210-9
Article CAS PubMed Google Scholar
Guo Q, Bin H, Cheng J, Seefelder M, Engler T, Pfeifer G, Oeckl P, Otto M et al. (2018) The cryo-electron microscopy structure of huntingtin. Nature 555(7694):117–120. https://doi.org/10.1038/nature25502
Article CAS PubMed PubMed Central Google Scholar
Pearce MMP, Spartz EJ, Hong W, Luo L, Kopito RR (2015) Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain. Nat Commun 6:6768. https://doi.org/10.1038/ncomms7768
Article CAS PubMed Google Scholar
Prasad A, Bharathi V, Sivalingam V, Girdhar A, Patel BK (2019) Molecular mechanisms of TDP-43 misfolding and pathology in amyotrophic lateral sclerosis. Front Mol Neurosci 12:25. https://doi.org/10.3389/fnmol.2019.00025
Article CAS PubMed PubMed Central Google Scholar
Falcon B, Zhang W, Schweighauser M, Murzin AG, Vidal R, Garringer HJ, Ghetti B, Scheres SHW et al. (2018) Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold. Acta Neuropathol 136(5):699–708. https://doi.org/10.1007/s00401-018-1914-z
Article CAS PubMed PubMed Central Google Scholar
Muntane G, Dalfo E, Martinez A, Ferrer I (2008) Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer’s disease, and in Parkinson’s disease and related alpha-synucleinopathies. Neuroscience 152(4):913–923. https://doi.org/10.1016/j.neuroscience.2008.01.030
Article CAS PubMed Google Scholar
Moore DJ, West AB, Dawson VL, Dawson TM (2005) Molecular pathophysiology of Parkinson’s disease. Annu Rev Neurosci 28:57–87. https://doi.org/10.1146/annurev.neuro.28.061604.135718
Article CAS PubMed Google Scholar
Bourdenx M, Koulakiotis NS, Sanoudou D, Bezard E, Dehay B, Tsarbopoulos A (2017) Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: examples of amyloidopathies, tauopathies and synucleinopathies. Prog Neurobiol 155:171–193. https://doi.org/10.1016/j.pneurobio.2015.07.003
Article CAS PubMed Google Scholar
Benilova I, Karran E, De Strooper B (2012) The toxic Abeta oligomer and Alzheimer’s disease: an emperor in need of clothes. Nat Neurosci 15(3):349–357. https://doi.org/10.1038/nn.3028
Article CAS PubMed Google Scholar
Castillo-Carranza DL, Gerson JE, Sengupta U, Guerrero-Munoz MJ, Lasagna-Reeves CA, Kayed R (2014) Specific targeting of tau oligomers in Htau mice prevents cognitive impairment and tau toxicity following injection with brain-derived tau oligomeric seeds. J Alzheimers Dis 40(Suppl 1):S97–S111. https://doi.org/10.3233/JAD-132477
Article CAS PubMed Google Scholar
Cohen TJ, Lee VM, Trojanowski JQ (2011) TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies. Trends Mol Med 17(11):659–667. https://doi.org/10.1016/j.molmed.2011.06.004
Article CAS PubMed PubMed Central Google Scholar
Ekimova IV, Plaksina DV, Pastukhov YF, Lapshina KV, Lazarev VF, Mikhaylova ER, Polonik SG, Pani B et al. (2018) New HSF1 inducer as a therapeutic agent in a rodent model of Parkinson’s disease. Exp Neurol 306:199–208. https://doi.org/10.1016/j.expneurol.2018.04.012
Article CAS PubMed Google Scholar
Buchberger A, Bukau B, Sommer T (2010) Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms. Mol Cell 40(2):238–252. https://doi.org/10.1016/j.molcel.2010.10.001
Article CAS PubMed Google Scholar
Neus Bosch M, Pugliese M, Andrade C, Gimeno-Bayon J, Mahy N, Rodriguez MJ (2015) Amyloid-beta immunotherapy reduces amyloid plaques and astroglial reaction in aged domestic dogs. Neurodegener Dis 15(1):24–37. https://doi.org/10.1159/000368672
Article CAS PubMed Google Scholar
Xing HY, Li B, Peng D, Wang CY, Wang GY, Li P, Le YY, Wang JM et al. (2017) A novel monoclonal antibody against the N-terminus of Abeta1-42 reduces plaques and improves cognition in a mouse model of Alzheimer’s disease. PLoS ONE 12(6):e0180076. https://doi.org/10.1371/journal.pone.0180076
Article CAS PubMed PubMed Central Google Scholar
Schenk DB, Koller M, Ness DK, Griffith SG, Grundman M, Zago W, Soto J, Atiee G, Ostrowitzki S, Kinney GG (2017) First-in-human assessment of PRX002, an anti-alpha-synuclein monoclonal antibody, in healthy volunteers. Mov Disord 32(2):211–218. https://doi.org/10.1002/mds.26878
Article CAS PubMed Google Scholar
Silveira CRA, MacKinley J, Coleman K, Li Z, Finger E, Bartha R, Morrow SA, Wells J et al. (2019) Ambroxol as a novel disease-modifying treatment for Parkinson’s disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial. BMC Neurol 19(1):20. https://doi.org/10.1186/s12883-019-1252-3
Article CAS PubMed PubMed Central Google Scholar
Qu J, Ren X, Xue F, He Y, Zhang R, Zheng Y, Huang H, Wang W et al. (2020) Specific knockdown of alpha-synuclein by peptide-directed proteasome degradation rescued its associated neurotoxicity. Cell Chem Biol 27(6):751-762 e754. https://doi.org/10.1016/j.chembiol.2020.03.010
Article CAS PubMed Google Scholar
McFarthing K, Simuni T (2019) Clinical trial highlights: targetting alpha-synuclein. J Parkinsons Dis 9(1):5–16. https://doi.org/10.3233/JPD-189004
Honig LS, Vellas B, Woodward M, Boada M, Bullock R, Borrie M, Hager K, Andreasen N et al. (2018) Trial of solanezumab for mild dementia due to Alzheimer’s disease. N Engl J Med 378(4):321–330. https://doi.org/10.1056/NEJMoa1705971
Article CAS PubMed Google Scholar
Sweeney P, Park H, Baumann M, Dunlop J, Frydman J, Kopito R, McCampbell A, Leblanc G et al. (2017) Protein misfolding in neurodegenerative diseases: implications and strategies. Transl Neurodegener 6:6. https://doi.org/10.1186/s40035-017-0077-5
Article CAS PubMed PubMed Central Google Scholar
Gurry T, Stultz CM (2014) Mechanism of amyloid-beta fibril elongation. Biochemistry 53(44):6981–6991. https://doi.org/10.1021/bi500695g
Article CAS PubMed Google Scholar
Yang PH, Zhu JX, Huang YD, Zhang XY, Lei P, Bush AI, Xiang Q, Su ZJ et al. (2016) Human basic fibroblast growth factor inhibits tau phosphorylation via the PI3K/Akt-GSK3beta signaling pathway in a 6-hydroxydopamine-induced model of Parkinson’s disease. Neurodegener Dis 16(5–6):357–369. https://doi.org/10.1159/000445871
Article CAS PubMed Google Scholar
Goedert M (2001) Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci 2(7):492–501. https://doi.org/10.1038/35081564
Article CAS PubMed Google Scholar
Buee L, Bussiere T, Buee-Scherrer V, Delacourte A, Hof PR (2000) Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev 33(1):95–130. https://doi.org/10.1016/s0165-0173(00)00019-9
Article CAS PubMed Google Scholar
Spillantini MG, Goedert M (2013) Tau pathology and neurodegeneration. Lancet Neurol 12(6):609–622. https://doi.org/10.1016/S1474-4422(13)70090-5
Article CAS PubMed Google Scholar
Sanghai N, Tranmer GK (2021) Hydrogen peroxide and amyotrophic lateral sclerosis: from biochemistry to pathophysiology. Antioxidants (Basel) 11 (1). https://doi.org/10.3390/antiox11010052
Koyuncu S, Fatima A, Gutierrez-Garcia R, Vilchez D (2017) Proteostasis of huntingtin in health and disease. Int J Mol Sci 18 (7). https://doi.org/10.3390/ijms18071568
Baldwin KJ, Correll CM (2019) Prion disease. Semin Neurol 39(4):428–439. https://doi.org/10.1055/s-0039-1687841
留言 (0)