Transplantation of Nasal Olfactory Mucosa Mesenchymal Stem Cells Benefits Alzheimer’s Disease

Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, Brayne C, Burns A et al (2020) Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet (London, England) 396(10248):413–446. https://doi.org/10.1016/S0140-6736(20)30367-6

Article  Google Scholar 

Ljubic B, Roychoudhury S, Cao XH, Pavlovski M, Obradovic S, Nair R, Glass L, Obradovic Z (2020) Influence of medical domain knowledge on deep learning for Alzheimer’s disease prediction. Comput Methods Programs Biomed 197:105765. https://doi.org/10.1016/j.cmpb.2020.105765

Article  PubMed  PubMed Central  Google Scholar 

De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV (2012) Alzheimer’s disease. Subcell Biochem 65:329–352. https://doi.org/10.1007/978-94-007-5416-4_14

Article  CAS  PubMed  Google Scholar 

Breijyeh Z, Karaman R (2020) Comprehensive review on Alzheimer’s disease: causes and treatment. Molecules 25(24). https://doi.org/10.3390/molecules25245789

Hampel H, Vassar R, De Strooper B, Hardy J, Willem M, Singh N, Zhou J, Yan R et al (2021) The beta-secretase BACE1 in Alzheimer’s disease. Biol Psychiatry 89(8):745–756. https://doi.org/10.1016/j.biopsych.2020.02.001

Article  CAS  PubMed  Google Scholar 

Alexander GC, Knopman DS, Emerson SS, Ovbiagele B, Kryscio RJ, Perlmutter JS, Kesselheim AS (2021) Revisiting FDA approval of aducanumab. N Engl J Med 385(9):769–771. https://doi.org/10.1056/NEJMp2110468

Article  CAS  PubMed  Google Scholar 

Rabinovici GD (2021) Controversy and progress in Alzheimer’s disease - FDA approval of aducanumab. N Engl J Med 385(9):771–774. https://doi.org/10.1056/NEJMp2111320

Article  CAS  PubMed  Google Scholar 

Yiannopoulou KG, Papageorgiou SG (2020) Current and future treatments in Alzheimer disease: an update. J Cent Nerv Syst Dis 12:1179573520907397. https://doi.org/10.1177/1179573520907397

Article  PubMed  PubMed Central  Google Scholar 

Hassanzadeh A, Rahman HS, Markov A, Endjun JJ, Zekiy AO, Chartrand MS, Beheshtkhoo N, Kouhbanani MAJ et al (2021) Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities. Stem Cell Res Ther 12(1):297. https://doi.org/10.1186/s13287-021-02378-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moghadasi S, Elveny M, Rahman HS, Suksatan W, Jalil AT, Abdelbasset WK, Yumashev AV, Shariatzadeh S et al (2021) A paradigm shift in cell-free approach: the emerging role of MSCs-derived exosomes in regenerative medicine. J Transl Med 19(1):302. https://doi.org/10.1186/s12967-021-02980-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie Q, Liu R, Jiang J, Peng J, Yang C, Zhang W, Wang S, Song J (2020) What is the impact of human umbilical cord mesenchymal stem cell transplantation on clinical treatment? Stem Cell Res Ther 11(1):519. https://doi.org/10.1186/s13287-020-02011-z

Article  PubMed  PubMed Central  Google Scholar 

Park BW, Jung SH, Das S, Lee SM, Park JH, Kim H, Hwang JW, Lee S et al (2020) In vivo priming of human mesenchymal stem cells with hepatocyte growth factor-engineered mesenchymal stem cells promotes therapeutic potential for cardiac repair. Sci Adv 6(13):eaay6994. https://doi.org/10.1126/sciadv.aay6994

Article  CAS  PubMed  PubMed Central  Google Scholar 

Staff NP, Jones DT, Singer W (2019) Mesenchymal stromal cell therapies for neurodegenerative diseases. Mayo Clin Proc 94(5):892–905. https://doi.org/10.1016/j.mayocp.2019.01.001

Article  PubMed  Google Scholar 

Teixeira FG, Carvalho MM, Panchalingam KM, Rodrigues AJ, Mendes-Pinheiro B, Anjo S, Manadas B, Behie LA et al (2017) Impact of the secretome of human mesenchymal stem cells on brain structure and animal behavior in a rat model of Parkinson’s disease. Stem Cells Transl Med 6(2):634–646. https://doi.org/10.5966/sctm.2016-0071

Article  CAS  PubMed  Google Scholar 

Guo M, Yin Z, Chen F, Lei P (2020) Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer’s disease. Alzheimers Res Ther 12(1):109. https://doi.org/10.1186/s13195-020-00670-x

Article  PubMed  PubMed Central  Google Scholar 

Cui GH, Wu J, Mou FF, Xie WH, Wang FB, Wang QL, Fang J, Xu YW et al (2018) Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice. FASEB J 32(2):654–668. https://doi.org/10.1096/fj.201700600R

Article  CAS  PubMed  Google Scholar 

Losurdo M, Pedrazzoli M, D’Agostino C, Elia CA, Massenzio F, Lonati E, Mauri M, Rizzi L et al (2020) Intranasal delivery of mesenchymal stem cell-derived extracellular vesicles exerts immunomodulatory and neuroprotective effects in a 3xTg model of Alzheimer’s disease. Stem Cells Transl Med 9(9):1068–1084. https://doi.org/10.1002/sctm.19-0327

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cone AS, Yuan X, Sun L, Duke LC, Vreones MP, Carrier AN, Kenyon SM, Carver SR et al (2021) Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer’s disease-like phenotypes in a preclinical mouse model. Theranostics 11(17):8129–8142. https://doi.org/10.7150/thno.62069

Article  CAS  PubMed  PubMed Central  Google Scholar 

Delorme B, Nivet E, Gaillard J, Haupl T, Ringe J, Deveze A, Magnan J, Sohier J et al (2010) The human nose harbors a niche of olfactory ectomesenchymal stem cells displaying neurogenic and osteogenic properties. Stem Cells Dev 19(6):853–866. https://doi.org/10.1089/scd.2009.0267

Article  CAS  PubMed  Google Scholar 

Alvites RD, Branquinho MV, Caseiro AR, Amorim I, Santos Pedrosa S, Rema A, Faria F, Porto B et al (2020) Rat olfactory mucosa mesenchymal stem/stromal cells (OM-MSCs): a characterization study. Int J Cell Biol 2020:2938258. https://doi.org/10.1155/2020/2938258

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ge L, Jiang M, Duan D, Wang Z, Qi L, Teng X, Zhao Z, Wang L et al (2016) Secretome of olfactory mucosa mesenchymal stem cell, a multiple potential stem cell. Stem Cells Int 2016:1243659. https://doi.org/10.1155/2016/1243659

Article  CAS  PubMed  PubMed Central  Google Scholar 

Girard SD, Deveze A, Nivet E, Gepner B, Roman FS, Feron F (2011) Isolating nasal olfactory stem cells from rodents or humans. J Vis Exp (54). https://doi.org/10.3791/2762

Veron AD, Bienboire-Frosini C, Girard SD, Sadelli K, Stamegna JC, Khrestchatisky M, Alexis J, Pageat P et al (2018) Syngeneic transplantation of olfactory ectomesenchymal stem cells restores learning and memory abilities in a rat model of global cerebral ischemia. Stem Cells Int 2018:2683969. https://doi.org/10.1155/2018/2683969

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alvites RD, Branquinho MV, Sousa AC, Amorim I, Magalhaes R, Joao F, Almeida D, Amado S et al (2021) Combined use of chitosan and olfactory mucosa mesenchymal stem/stromal cells to promote peripheral nerve regeneration in vivo. Stem Cells Int 2021:6613029. https://doi.org/10.1155/2021/6613029

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lindsay SL, Toft A, Griffin J, Emraja AMM, Barnett SC, Riddell JS (2017) Human olfactory mesenchymal stromal cell transplants promote remyelination and earlier improvement in gait co-ordination after spinal cord injury. Glia 65(4):639–656. https://doi.org/10.1002/glia.23117

Article  PubMed  PubMed Central  Google Scholar 

Young E, Westerberg B, Yanai A, Gregory-Evans K (2018) The olfactory mucosa: a potential source of stem cells for hearing regeneration. Regen Med 13(5):581–593. https://doi.org/10.2217/rme-2018-0009

Article  CAS  PubMed  Google Scholar 

Qin C, Lu Y, Wang K, Bai L, Shi G, Huang Y, Li Y (2020) Transplantation of bone marrow mesenchymal stem cells improves cognitive deficits and alleviates neuropathology in animal models of Alzheimer’s disease: a meta-analytic review on potential mechanisms. Transl Neurodegener 9(1):20. https://doi.org/10.1186/s40035-020-00199-x

Article  PubMed  PubMed Central  Google Scholar 

Naaldijk Y, Jager C, Fabian C, Leovsky C, Bluher A, Rudolph L, Hinze A, Stolzing A (2017) Effect of systemic transplantation of bone marrow-derived mesenchymal stem cells on neuropathology markers in APP/PS1 Alzheimer mice. Neuropathol Appl Neurobiol 43(4):299–314. https://doi.org/10.1111/nan.12319

Article  CAS  PubMed  Google Scholar 

Ma T, Gong K, Ao Q, Yan Y, Song B, Huang H, Zhang X, Gong Y (2013) Intracerebral transplantation of adipose-derived mesenchymal stem cells alternatively activates microglia and ameliorates neuropathological deficits in Alzheimer’s disease mice. Cell Transplant 22(Suppl 1):S113-126. https://doi.org/10.3727/096368913X672181

Article  PubMed  Google Scholar 

Lee JK, Jin HK, Endo S, Schuchman EH, Carter JE, Bae JS (2010) Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer’s disease mice by modulation of immune responses. Stem Cells 28(2):329–343. https://doi.org/10.1002/stem.277

Article  CAS  PubMed  Google Scholar 

Nakano M, Kubota K, Kobayashi E, Chikenji TS, Saito Y, Konari N, Fujimiya M (2020) Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer’s disease model by increasing the expression of microRNA-146a in hippocampus. Sci Rep 10(1):10772. https://doi.org/10.1038/s41598-020-67460-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nivet E, Vignes M, Girard SD, Pierrisnard C, Baril N, Deveze A, Magnan J, Lante F et al (2011) Engraftment of human nasal olfactory stem cells restores neuroplasticity in mice with hippocampal lesions. J Clin Invest 121(7):2808–2820. https://doi.org/10.1172/JCI44489

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gangadaran P, Rajendran RL, Lee HW, Kalimuthu S, Hong CM, Jeong SY, Lee SW, Lee J et al (2017) Extracellular vesicles from mesenchymal stem cells activates VEGF receptors and accelerates recovery of hindlimb ischemia. J Control Release 264:112–126. https://doi.org/10.1016/j.jconrel.2017.08.022

Article  CAS  PubMed 

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