Owen MJ, Sawa A, Mortensen PB (2016) Schizophrenia. Lancet 388(10039):86–97. https://doi.org/10.1016/S0140-6736(15)01121-6
Article PubMed PubMed Central Google Scholar
Lo LE, Kaur R, Meiser B, Green MJ (2020) Risk of schizophrenia in relatives of individuals affected by schizophrenia: a meta-analysis. Psychiatry Res 286:112852. https://doi.org/10.1016/j.psychres.2020.112852
Sellgren CM et al (2019) Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning. Nat Neurosci 22(3):374–385
Article CAS PubMed PubMed Central Google Scholar
Blakemore S-J (2008) Development of the social brain during adolescence. Q J Exp Psychol 61(1):40–49
Darabid H, Perez-Gonzalez AP, Robitaille R (2014) Neuromuscular synaptogenesis: coordinating partners with multiple functions. Nat Rev Neurosci 15(11):703–718
Article CAS PubMed Google Scholar
Neniskyte U, Gross CT (2017) Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders. Nat Publ Gr 18(11):658–670. https://doi.org/10.1038/nrn.2017.110
Cardozo PL, De Lima IBQ, Maciel EMA, Silva NC (2019) Synaptic elimination in neurological disorders. Curr Neuropharmacol 17:1071–1095. https://doi.org/10.2174/1570159X17666190603170511
Article CAS PubMed PubMed Central Google Scholar
Presumey J, Bialas AR, Carroll MC (2017) Complement system in neural synapse elimination in development and disease, (1st ed. 135). Elsevier Inc
Gogtay N et al (2004) Dynamic mapping of human cortical development during childhood through early adulthood. Proc Natl Acad Sci 101(21):8174–8179
Article CAS PubMed PubMed Central Google Scholar
Riccomagno MM, Kolodkin AL (2015) Sculpting neural circuits by axon and dendrite pruning. Annu Rev Cell Dev Biol 31:779–805
Article CAS PubMed PubMed Central Google Scholar
Moran ME, Pol HH, Gogtay N (2013) A family affair: brain abnormalities in siblings of patients with schizophrenia. Brain 136(11):3215–3226. https://doi.org/10.1093/brain/awt116
Article PubMed PubMed Central Google Scholar
Sun D et al (2009) Brain surface contraction mapped in first-episode schizophrenia: a longitudinal magnetic resonance imaging study. Mol Psychiatry 14(10):976–986. https://doi.org/10.1038/mp.2008.34
Article CAS PubMed Google Scholar
Je HS, Yang F, Ji Y, Nagappan G, Hempstead BL, Lu B (2012) Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses. Proc Natl Acad Sci U S A 109(39):15924–15929. https://doi.org/10.1073/pnas.1207767109
Article PubMed PubMed Central Google Scholar
Bibel M, Barde Y-A (2000) Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev 14(23):2919–2937
Article CAS PubMed Google Scholar
Pezawas L et al (2004) The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci 24(45):10099–10102
Article CAS PubMed PubMed Central Google Scholar
Toll A, Mané A (2015) Brain-derived neurotrophic factor levels in first episode of psychosis: a systematic review. World J Psychiatry 5(1):154
Article PubMed PubMed Central Google Scholar
Der Chen S, Wu CL, Hwang WC, Yang DI (2017) More insight into BDNF against neurodegeneration: anti-apoptosis, anti-oxidation, and suppression of autophagy. Int J Mol Sci 18(3):1–12. https://doi.org/10.3390/ijms18030545
Yoshida T et al (2012) Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder. PLoS ONE 7(8):12–14. https://doi.org/10.1371/journal.pone.0042676
Yesilkaya UH, Gica S, Tasdemir BG, Menekseoglu PO, Cirakli Z, Karamustafalioglu N (2021) A novel commentary: investigation of the role of a balance between neurotrophic and apoptotic proteins in the pathogenesis of psychosis via the tPA-BDNF pathway. J Psychiatr Res 142:160–166
Allen AJ, Griss ME, Folley BS, Hawkins KA, Pearlson GD (2009) Endophenotypes in schizophrenia: a selective review. Schizophr Res 109(1–3):24–37
Article PubMed PubMed Central Google Scholar
Yee JY, Lee TS, Lee J (2019) A longitudinal study of serum brain-derived neurotrophic factor levels in first-episode schizophrenia. J Clin Psychopharmacol 39(6):639–643. https://doi.org/10.1097/JCP.0000000000001118
Article CAS PubMed Google Scholar
Favalli G, Li J, Belmonte-de-Abreu P, Wong AHC, Daskalakis ZJ (2012) The role of BDNF in the pathophysiology and treatment of schizophrenia. J Psychiatr Res 46(1):1–11. https://doi.org/10.1016/j.jpsychires.2011.09.022
Chen S et al (2017) Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders. Sci Rep 7(1):1–9. https://doi.org/10.1038/s41598-017-06832-6
Foltran RB, Diaz SL (2016) BDNF isoforms: a round trip ticket between neurogenesis and serotonin? J Neurochem 138(2):204–221
Article CAS PubMed Google Scholar
Kumar V, Zhang M-X, Swank MW, Kunz J, Wu G-Y (2005) Regulation of dendritic morphogenesis by Ras–PI3K–Akt–mTOR and Ras–MAPK signaling pathways. J Neurosci 25(49):11288–11299
Article CAS PubMed PubMed Central Google Scholar
Reichardt LF (2006) Neurotrophin-regulated signalling pathways. Philos Trans R Soc B Biol Sci 361(1473):1545–1564
Anastasia A et al (2013) Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction. Nat Commun 4(1):1–13
Gehler S, Gallo G, Veien E, Letourneau PC (2004) p75 neurotrophin receptor signaling regulates growth cone filopodial dynamics through modulating RhoA activity. J Neurosci 24(18):4363–4372
Article CAS PubMed PubMed Central Google Scholar
Bamji SX et al (1998) The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death. J Cell Biol 140(4):911–923
Article CAS PubMed PubMed Central Google Scholar
Kowiański P, Lietzau G, Czuba E, Waśkow M, Steliga A, Moryś J (2018) BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity. Cell Mol Neurobiol 38(3):579–593. https://doi.org/10.1007/s10571-017-0510-4
Article CAS PubMed Google Scholar
Yang J et al (2014) proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus. Cell Rep 7(3):796–806
Article CAS PubMed PubMed Central Google Scholar
Karanikas E, Antoniadis D, Garyfallos GD (2014) The role of cortisol in first episode of psychosis: a systematic review. Curr Psychiatry Rep 16(11):1–10. https://doi.org/10.1007/s11920-014-0503-7
Howes OD, McCutcheon R (2017) Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization. Transl Psychiatry 7(2):e1024–e1024
Article CAS PubMed PubMed Central Google Scholar
Hubbard DB, Miller BJ (2019) Meta-analysis of blood cortisol levels in individuals with first-episode psychosis. Psychoneuroendocrinology 104:269–275
Article CAS PubMed Google Scholar
Walsh P, Spelman L, Sharifi N, Thakore JH (2005) Male patients with paranoid schizophrenia have greater ACTH and cortisol secretion in response to metoclopramide-induced AVP release. Psychoneuroendocrinology 30(5):431–437
Article CAS PubMed Google Scholar
Hoirisch-Clapauch S, Nardi AE (2015) Improvement of psychotic symptoms and the role of tissue plasminogen activator. Int J Mol Sci 16(11):27550–27560. https://doi.org/10.3390/ijms161126053
Article CAS PubMed PubMed Central Google Scholar
Almonte AG, Sweatt JD (2011) Serine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behavior. Brain Res 1407:107–122
Article CAS PubMed PubMed Central Google Scholar
Elmi S, Sahu G, Malavade K, Jacob T (2019) Role of tissue plasminogen activator and plasminogen activator inhibitor as potential biomarkers in psychosis. Asian J Psychiatr 43(May):105–110. https://doi.org/10.1016/j.ajp.2019.05.021
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