Effect of electrical stimulation on oxidative stress in tissues in a rat model with incision wound
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https://doi.org/10.56042/ijeb.v60i11.55921Title: Effect of electrical stimulation on oxidative stress in tissues in a rat model with incision woundAuthors:
Kazak, FilizIşık, EgemenYurtal, ZiyaAlakuş, İbrahimKeywords: Electroteraphy;Glucose-6-phosphate dehydrogenase;Malondialdehyde;M. gastrocnemius;M. quadriceps femorisIssue Date: Nov-2022Publisher: NIScPR-CSIR, IndiaAbstract: Electrical stimulation (ES) are known to have beneficial effects in wound healing. However, the effect of electrical
stimulation in wound theraphy on the oxidant and antioxidant levels of various tissues in the body remains unclear. Here, we
investigated the effects of electrical stimulation on the oxidative stress capacity of tissues in a rat model with a surgical
incision wound on the lateral line of the femoral region. Rats divided in two groups: control and ES group. A longitudinal
skin incision was made only from the right lateral line of all rats. ES was applied 200 μs, 20 Hz, 2mA for 20 min during
15 days. Some oxidative stress parameters (malondialdehyde (MDA), reduced glutathione (rGSH), glucose-6-phosphate
dehydrogenase (G6PD), glutathione peroxidase (GPx) and catalase (CAT)) in tissues (brain, heart, kidney, liver,
testis, gastrocnemius and quadriceps femoris muscle) were obtained spectrophotometrically. The ES reduced oxidative
stress by decreasing MDA and simultaneously increasing different antioxidants in different tissues. The results suggest that
incision wound could induce oxidative stress in tissues and electrical stimulation post-incision wound may have
ameliorative effect.Page(s): 825-831ISSN: 0975-1009 (Online); 0019-5189 (Print)Appears in Collections:
IJEB Vol.60(11) [Nov 2022]Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.
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