Thariat, J., Hannoun-Levi, J.-M., Sun Myint, A., Vuong, T. & Gérard, J.-P. Past, present, and future of radiotherapy for the benefit of patients. Nat. Rev. Clin. Oncol. 10, 52–60 (2012).
Coutard, H. Principles of X-ray therapy of malignant diseases. Lancet 224, 1–8 (1934).
Lo, S. S. et al. Stereotactic body radiation therapy: a novel treatment modality. Nat. Rev. Clin. Oncol. 7, 44–54 (2010).
Dewey, D. L. & Boag, J. W. Modification of the oxygen effect when bacteria are given large pulses of radiation. Nature 183, 1450–1451 (1959).
Town, C. D. Radiobiology. Effect of high dose rates on survival of mammalian cells. Nature 215, 847–848 (1967).
Berry, R. J., Hall, E. J., Forster, D. W., Storr, T. H. & Goodman, M. J. Survival of mammalian cells exposed to x rays at ultra-high dose-rates. Br. J. Radiol. 42, 102–107 (1969).
Hornsey, S. & Bewley, D. K. Hypoxia in mouse intestine induced by electron irradiation at high dose-rates. Int. J. Radiat. Biol. Relat. Stud. Phys., Chem. Med. 19, 479–483 (1971).
Field, S. B. & Bewley, D. K. Effects of dose-rate on the radiation response of rat skin. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 26, 259–267 (1974).
Hendry, J. H., Moore, J. V., Hodgson, B. W. & Keene, J. P. The constant low oxygen concentration in all the target cells for mouse tail radionecrosis. Radiat. Res. 92, 172–181 (1982).
Favaudon, V. et al. Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice. Sci. Transl. Med. 6, 245ra93 (2014).
Farr, J. B., Parodi, K. & Carlson, D. J. FLASH: current status and the transition to clinical use. Med. Phys. 49, 1972–1973 (2022).
Lin, B. et al. FLASH radiotherapy: history and future. Front. Oncol. 11, 644400 (2021).
PubMed PubMed Central Google Scholar
Kacem, H., Almeida, A., Cherbuin, N. & Vozenin, M.-C. Understanding the FLASH effect to unravel the potential of ultra-high dose rate irradiation. Int. J. Radiat. Biol. 98, 506–516 (2022).
Borghini, A. et al. FLASH ultra-high dose rates in radiotherapy: preclinical and radiobiological evidence. Int. J. Radiat. Biol. 98, 127–135 (2022).
Durante, M., Brauer-Krisch, E. & Hill, M. Faster and safer? FLASH ultra-high dose rate in radiotherapy. Br. J. Radiol. 91, 20170628 (2017).
Vozenin, M. C., Hendry, J. H. & Limoli, C. L. Biological benefits of ultra-high dose rate FLASH radiotherapy: sleeping beauty awoken. Clin. Oncol. 31, 407–415 (2019).
Beddok, A. et al. A comprehensive analysis of the relationship between dose rate and biological effects in preclinical and clinical studies, from brachytherapy to flattening filter free radiation therapy and FLASH irradiation. Int. J. Radiat. Oncol. 113, 985–995 (2022).
Vozenin, M. C., Montay-Gruel, P., Limoli, C. & Germond, J. F. All Irradiations that are ultra-high dose rate may not be FLASH: the critical importance of beam parameter characterization and in vivo validation of the FLASH effect. Radiat. Res. 194, 571–572 (2020).
Wilson, J. D., Hammond, E. M., Higgins, G. S. & Petersson, K. Ultra-high dose rate (FLASH) radiotherapy: silver bullet or fool’s gold? Front. Oncol. 9, 1563 (2020).
PubMed PubMed Central Google Scholar
Schüler, E. et al. Ultra‐high dose rate electron beams and the FLASH effect: from preclinical evidence to a new radiotherapy paradigm. Med. Phys. 49, 2082–2095 (2022).
Rothwell, B. C. et al. Determining the parameter space for effective oxygen depletion for FLASH radiation therapy. Phys. Med. Biol. 66, 055020 (2021).
Bourhis, J. et al. Clinical translation of FLASH radiotherapy: why and how? Radiother. Oncol. 139, 11–17 (2019).
Bourhis, J. et al. Treatment of a first patient with FLASH-radiotherapy. Radiother. Oncol. 139, 18–22 (2019).
Gaide, O. et al. Comparison of ultra-high versus conventional dose rate radiotherapy in a patient with cutaneous lymphoma. Radiother. Oncol. 174, 87–91 (2022).
Taylor, P. A., Moran, J. M., Jaffray, D. A. & Buchsbaum, J. C. A roadmap to clinical trials for FLASH. Med. Phys. 49, 4099–4108 (2022).
Montay-Gruel, P. et al. Hypofractionated FLASH-RT as an effective treatment against glioblastoma that reduces neurocognitive side effects in mice. Clin. Cancer Res. 27, 775–784 (2021).
MacKay, R. et al. FLASH radiotherapy: considerations for multibeam and hypofractionation dose delivery. Radiother. Oncol. 164, 122–127 (2021).
Jaccard, M. et al. High dose-per-pulse electron beam dosimetry: usability and dose-rate independence of EBT3 gafchromic films. Med. Phys. 44, 725–735 (2017).
Jorge, P. G. et al. Dosimetric and preparation procedures for irradiating biological models with pulsed electron beam at ultra-high dose-rate. Radiother. Oncol. 139, 34–39 (2019).
Schüler, E. et al. Experimental platform for ultra-high dose rate FLASH irradiation of small animals using a clinical linear accelerator. Int. J. Radiat. Oncol. Biol. Phys. 97, 195–203 (2017).
Lempart, M. et al. Modifying a clinical linear accelerator for delivery of ultra-high dose rate irradiation. Radiother. Oncol. 139, 40–45 (2019).
Rahman, M. et al. Electron FLASH delivery at treatment room isocenter for efficient reversible conversion of a clinical LINAC. Int. J. Radiat. Oncol. 110, 872–882 (2021).
Lansonneur, P. et al. Simulation and experimental validation of a prototype electron beam linear accelerator for preclinical studies. Phys. Med. 60, 50–57 (2019).
Felici, G. et al. Transforming an IORT linac into a FLASH research machine: procedure and dosimetric characterization. Front. Phys. 8, 374 (2020).
Di Martino, F. et al. FLASH radiotherapy with electrons: issues related to the production, monitoring, and dosimetric characterization of the beam. Front. Phys. 8, 570697 (2020).
Moeckli, R. et al. Commissioning of an ultra‐high dose rate pulsed electron beam medical LINAC for FLASH RT preclinical animal experiments and future clinical human protocols. Med. Phys. 48, 3134–3142 (2021).
Jaccard, M. et al. High dose-per-pulse electron beam dosimetry: commissioning of the oriatron eRT6 prototype linear accelerator for preclinical use. Med. Phys. 45, 863–874 (2018).
Whitmore, L., Mackay, R. I., van Herk, M., Jones, J. K. & Jones, R. M. Focused VHEE (very high energy electron) beams and dose delivery for radiotherapy applications. Sci. Rep. 11, 14013 (2021).
CAS PubMed PubMed Central Google Scholar
Sarti, A. et al. Deep seated tumour treatments with electrons of high energy delivered at FLASH rates: the example of prostate cancer. Front. Oncol. 11, 777852 (2021).
PubMed PubMed Central Google Scholar
Ronga, M. G. et al. Back to the future: very high-energy electrons (VHEEs) and their potential application in radiation therapy. Cancers 13, 4942 (2021).
PubMed PubMed Central Google Scholar
Hooker, S. M. Developments in laser-driven plasma accelerators. Nat. Photonics 7, 775–782 (2013).
Peralta, E. A. et al. Demonstration of electron acceleration in a laser-driven dielectric microstructure. Nature 503, 91–94 (2013).
Montay-Gruel, P., Corde, S., Laissue, J. A. & Bazalova-Carter, M. FLASH radiotherapy with photon beams. Med. Phys. 49, 2055–2067 (2022).
Montay-Gruel, P. et al. X-rays can trigger the FLASH effect: ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice. Radiother. Oncol. 129, 582–588 (2018).
Smyth, L. M. L. et al. Comparative toxicity of synchrotron and conventional radiation therapy based on total and partial body irradiation in a murine model. Sci. Rep. 8, 12044 (2018).
PubMed PubMed Central Google Scholar
Eling, L. et al. Ultra high dose rate synchrotron microbeam radiation therapy. Preclinical evidence in view of a clinical transfer. Radiother. Oncol. 139, 56–61 (2019).
Rezaee, M., Iordachita, I. & Wong, J. W. Ultrahigh dose-rate (FLASH) X-ray irradiator for pre-clinical laboratory research. Phys. Med. Biol. 66, 095006 (2021).
Gao, F. et al. First demonstration of the FLASH effect with ultrahigh dose rate high-energy X-rays. Radiother. Oncol. 166, 44–50 (2022).
Maxim, P. G., Tantawi, S. G. & Loo, B. W. PHASER: a platform for clinical translation of FLASH cancer radiotherapy. Radiother. Oncol. 139, 28–33 (2019).
Durante, M., Orecchia, R. & Loeffler, J. S. Charged-particle therapy in cancer: clinical uses and future perspectives. Nat. Rev. Clin. Oncol. 14, 483–495 (2017).
Durante, M. & Paganetti, H. Nuclear physics in particle therapy: a review. Rep. Prog. Phys. 79, 096702 (2016).
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