Available online 27 October 2022
Highlights•Evaluating immunoprotection status may facilitate the design of pharmaceutical vaccines.
•Variations in SARS-CoV-2, vaccines, and complications can affect immunoprotection.
•Techniques for etiological diagnosis of COVID-19 at the population scale were discussed.
AbstractThe strikingly rapidly mutating nature of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome has been a constant challenge during the coronavirus disease 2019 (COVID-19) pandemic. In this study, various techniques, including reverse transcription-quantitative polymerase chain reaction, antigen-detection rapid diagnostic tests, and high-throughput sequencing were analyzed under different scenarios and spectra for the etiological diagnosis of COVID-19 at the population scale. This study aimed to summarize the latest research progress and provide up-to-date understanding of the methodology used for the evaluation of the immunoprotection conditions against future variants of SARS-CoV-2. Our novel work reviewed the current methods for the evaluation of the immunoprotection status of a specific population (endogenous antibodies) before and after vaccine inoculation (administered with biopharmaceutical antibody products). The present knowledge of immunoprotection status regarding the COVID-19 complications was also discussed. Knowledge on the immunoprotection status of specific populations could help guide the design of pharmaceutical antibody products, inform practice guidelines, and develop national regulations with respect to the timing of and need for extra rounds of vaccine boosters.
KeywordsCOVID-19
etiological diagnosis
immunoprotection
SARS-CoV-2 variants
vaccine
complications
© 2022 The Author(s). Published by Elsevier B.V. on behalf of Xi’an Jiaotong University.
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