Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum. 2012;64(6):1697–707.

Article  PubMed  PubMed Central  Google Scholar 

Bapat S, Hubbard D, Munjal A, Hunter M, Fulzele S. Pros and cons of mouse models for studying osteoarthritis. Clin Transl Med. 2018;7(1):36.

Article  PubMed  PubMed Central  Google Scholar 

Miyaki S, Sato T, Inoue A, Otsuki S, Ito Y, Yokoyama S, et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev. 2010;24(11):1173–85.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Takada T, Miyaki S, Ishitobi H, Hirai Y, Nakasa T, Igarashi K, et al. Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1. Arthritis Res Ther. 2015;17:285.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sumiyoshi N, Ishitobi H, Miyaki S, Miyado K, Adachi N, Ochi M. The role of tetraspanin CD9 in osteoarthritis using three different mouse models. Biomed Res. 2016;37(5):283–91.

Article  PubMed  CAS  Google Scholar 

Chang SH, Mori D, Kobayashi H, Mori Y, Nakamoto H, Okada K, et al. Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-kappaB pathway. Nat Commun. 2019;10(1):1442.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Das-Gupta EP, Lyons TJ, Hoyland JA, Lawton DM, Freemont AJ. New histological observations in spontaneously developing osteoarthritis in the STR/ORT mouse questioning its acceptability as a model of human osteoarthritis. Int J Exp Pathol. 1993;74(6):627–34.

PubMed  PubMed Central  CAS  Google Scholar 

Staines KA, Poulet B, Wentworth DN, Pitsillides AA. The STR/ort mouse model of spontaneous osteoarthritis - an update. Osteoarthritis Cartilage. 2017;25(6):802–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Takeda T. Senescence-accelerated mouse (SAM): a biogerontological resource in aging research. Neurobiol Aging. 1999;20(2):105–10.

Article  PubMed  CAS  Google Scholar 

Takeda T. Senescence-accelerated mouse (SAM) with special references to neurodegeneration models, SAMP8 and SAMP10 mice. Neurochem Res. 2009;34(4):639–59.

Article  PubMed  CAS  Google Scholar 

Guo AY, Leung KS, Siu PM, Qin JH, Chow SK, Qin L, et al. Muscle mass, structural and functional investigations of senescence-accelerated mouse P8 (SAMP8). Exp Anim. 2015;64(4):425–33.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Malaise O, Tachikart Y, Constantinides M, Mumme M, Ferreira-Lopez R, Noack S, et al. Mesenchymal stem cell senescence alleviates their intrinsic and seno-suppressive paracrine properties contributing to osteoarthritis development. Aging (Albany NY). 2019;11(20):9128–46.

Article  CAS  Google Scholar 

Nagira K, Ikuta Y, Shinohara M, Sanada Y, Omoto T, Kanaya H, et al. Histological scoring system for subchondral bone changes in murine models of joint aging and osteoarthritis. Sci Rep. 2020;10(1):10077.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Glasson SS, Chambers MG, Van Den Berg WB, Little CB. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage. 2010;18(Suppl 3):S17-23.

Article  PubMed  Google Scholar 

Kwok J, Onuma H, Olmer M, Lotz MK, Grogan SP, D’Lima DD. Histopathological analyses of murine menisci: implications for joint aging and osteoarthritis. Osteoarthritis Cartilage. 2016;24(4):709–18.

Article  PubMed  CAS  Google Scholar 

Krenn V, Morawietz L, Haupl T, Neidel J, Petersen I, Konig A. Grading of chronic synovitis–a histopathological grading system for molecular and diagnostic pathology. Pathol Res Pract. 2002;198(5):317–25.

Article  PubMed  CAS  Google Scholar 

Ishitobi H, Sanada Y, Kato Y, Ikuta Y, Shibata S, Yamasaki S, et al. Carnosic acid attenuates cartilage degeneration through induction of heme oxygenase-1 in human articular chondrocytes. Eur J Pharmacol. 2018;830:1–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yahara Y, Takemori H, Okada M, Kosai A, Yamashita A, Kobayashi T, et al. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Nat Commun. 2016;7:10959.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, et al. Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat Med. 2010;16(6):678–86.

Article  PubMed  CAS  Google Scholar 

Rim YA, Nam Y, Ju JH. The role of chondrocyte hypertrophy and senescence in osteoarthritis initiation and progression. Int J Mol Sci. 2020;21(7):2358.

Article  PubMed Central  CAS  Google Scholar 

Loeser RF, Collins JA, Diekman BO. Ageing and the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016;12(7):412–20.

Article  PubMed  PubMed Central  CAS  Google Scholar 

McCulloch K, Litherland GJ, Rai TS. Cellular senescence in osteoarthritis pathology. Aging Cell. 2017;16(2):210–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hou A, Chen P, Tang H, Meng H, Cheng X, Wang Y, et al. Cellular senescence in osteoarthritis and anti-aging strategies. Mech Ageing Dev. 2018;175:83–7.

Article  PubMed  CAS  Google Scholar 

Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, et al. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nat Med. 2017;23(6):775–81.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sessions GA, Copp ME, Liu JY, Sinkler MA, D’Costa S, Diekman BO. Controlled induction and targeted elimination of p16(INK4a)-expressing chondrocytes in cartilage explant culture. Faseb j. 2019;33(11):12364–73.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Diekman BO, Sessions GA, Collins JA, Knecht AK, Strum SL, Mitin NK, et al. Expression of p16(INK) (4a) is a biomarker of chondrocyte aging but does not cause osteoarthritis. Aging Cell. 2018;17(4):e12771.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lampropoulou-Adamidou K, Lelovas P, Karadimas EV, Liakou C, Triantafillopoulos IK, Dontas I, et al. Useful animal models for the research of osteoarthritis. Eur J Orthop Surg Traumatol. 2014;24(3):263–71.

Article  PubMed  Google Scholar 

Lapveteläinen T, Hyttinen M, Lindblom J, Långsjö TK, Sironen R, Li SW, et al. More knee joint osteoarthritis (OA) in mice after inactivation of one allele of type II procollagen gene but less OA after lifelong voluntary wheel running exercise. Osteoarthritis Cartilage. 2001;9(2):152–60.

Article  PubMed  Google Scholar 

Tanisawa K, Mikami E, Fuku N, Honda Y, Honda S, Ohsawa I, et al. Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes. BMC Genomics. 2013;14:248.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Pang KC, Miller JP, Fortress A, McAuley JD. Age-related disruptions of circadian rhythm and memory in the senescence-accelerated mouse (SAMP8). Age (Dordr). 2006;28(3):283–96.

Article  Google Scholar 

Chikamoto A, Sekizawa SI, Tochinai R, Kuwahara M. Early attenuation of autonomic nervous function in senescence accelerated mouse-prone 8 (SAMP8). Exp Anim. 2019;68(4):511–7.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Allison DB, Ren G, Peliciari-Garcia RA, Mia S, McGinnis GR, Davis J, et al. Diurnal, metabolic and thermogenic alterations in a murine model of accelerated aging. Chronobiol Int. 2020;37(8):1119–39.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, et al. Targeting cellular senescence prevents age-related bone loss in mice. Nat Med. 2017;23(9):1072–9.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hwang HS, Kim HA. Chondrocyte apoptosis in the pathogenesis of osteoarthritis. Int J Mol Sci. 2015;16(11):26035–54.

Article  PubMed  PubMed Central  CAS