Prevalence of obesity among adults, BMI >= 30 (crude estimate) (%). In. https://www.who.int/data/gho/data/indicators/indicator-details/GHO/prevalence-of-obesity-among-adults-bmi-=-30-(crude-estimate)-(-).
Senaratna CV, Perret JL, Lodge CJ, Lowe AJ, Campbell BE, Matheson MC, et al. Prevalence of obstructive sleep apnea in the general population: a systematic review. Sleep Med Rev. 2017;34:70–81.
Dempsey JA, Veasey SC, Morgan BJ, O’Donnell CP. Pathophysiology of sleep apnea. Physiol Rev. 2010;90:47–112.
Article PubMed PubMed Central CAS Google Scholar
Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF, et al. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol. 2004;43:678–83.
Article PubMed CAS Google Scholar
Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116:281–97.
Article PubMed CAS Google Scholar
Feng S, Cong S, Zhang X, Bao X, Wang W, Li H, et al. MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells. Nucleic Acids Res. 2011;39:6669–78.
Article PubMed PubMed Central CAS Google Scholar
Gagan J, Dey BK, Layer R, Yan Z, Dutta A. MicroRNA-378 targets the myogenic repressor MyoR during myoblast differentiation. J Biol Chem. 2011;286:19431–8.
Article PubMed PubMed Central CAS Google Scholar
Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res. 2005;65:6029–33.
Article PubMed CAS Google Scholar
Chen JJ, Zhao B, Zhao J, Li S. Potential roles of exosomal MicroRNAs as diagnostic biomarkers and therapeutic application in Alzheimer’s disease. Neural Plastic. 2017;2017:7027380.
Kalra H, Drummen GP, Mathivanan S. Focus on extracellular vesicles: introducing the next small big thing. Int J Mol Sci. 2016;17:170.
Article PubMed PubMed Central Google Scholar
Hugel B, Martinez MC, Kunzelmann C, Freyssinet JM. Membrane microparticles: two sides of the coin. Physiology. 2005;20:22–7.
Article PubMed CAS Google Scholar
Trayhurn P. Hypoxia and adipose tissue function and dysfunction in obesity. Physiol Rev. 2013;93:1–21.
Article PubMed CAS Google Scholar
Kulshreshtha R, Ferracin M, Wojcik SE, Garzon R, Alder H, Agosto-Perez FJ, et al. A microRNA signature of hypoxia. Mol Cell Biol. 2007;27:1859–67.
Article PubMed PubMed Central CAS Google Scholar
Ivan M, Harris AL, Martelli F, Kulshreshtha R. Hypoxia response and microRNAs: no longer two separate worlds. J Cell Mol Med. 2008;12:1426–31.
Article PubMed PubMed Central CAS Google Scholar
Lacedonia D, Scioscia G, Palladino GP, Gallo C, Carpagnano GE, Sabato R, et al. MicroRNA expression profile during different conditions of hypoxia. Oncotarget. 2018;9:35114–22.
Article PubMed PubMed Central Google Scholar
Lázaro J, Clavería P, Cabrejas C, Fernando J, Daga B, Ordoñez B, et al. Epigenetics dysfunction in morbid obesity with or without obstructive sleep apnoea: the EPIMOOSA study. Respir Res. 2020;21:42.
Article PubMed PubMed Central Google Scholar
Lloberes P, Durán-Cantolla J, Martínez-García M, Marín J, Ferrer A, Corral J, et al. Diagnóstico y tratamiento del síndrome de apneas-hipopneas del sueño. Archiv Bronconeumol. 2011;47:143–56.
Sanz-Rubio D, Martin-Burriel I, Gil A, Cubero P, Forner M, Khalyfa A, et al. Stability of circulating exosomal miRNAs in healthy subjects. Sci Rep. 2018;8:10306.
Article PubMed PubMed Central Google Scholar
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25:402–8.
Article PubMed CAS Google Scholar
Dixon JB, Schachter LM, O’Brien PE. Predicting sleep apnea and excessive day sleepiness in the severely obese: indicators for polysomnography. Chest. 2003;123:1134–41.
Kositanurit W, Muntham D, Udomsawaengsup S, Chirakalwasan N. Prevalence and associated factors of obstructive sleep apnea in morbidly obese patients undergoing bariatric surgery. Sleep Breath. 2018;22:251–6.
Lecube A, Sampol G, Lloberes P, Romero O, Mesa J, Morell F, et al. Asymptomatic sleep-disordered breathing in premenopausal women awaiting bariatric surgery. Obes Surg. 2010;20:454–61.
Peromaa-Haavisto P, Tuomilehto H, Kossi J, Virtanen J, Luostarinen M, Pihlajamaki J, et al. Obstructive sleep apnea: the effect of bariatric surgery after 12 months. A prospective multicenter trial. Sleep Med. 2017;35:85–90.
Article PubMed CAS Google Scholar
Sharkey KM, Machan JT, Tosi C, Roye GD, Harrington D, Millman RP. Predicting obstructive sleep apnea among women candidates for bariatric surgery. Journal of women’s health. 2010;19:1833–41.
Dewan NA, Nieto FJ, Somers VK. Intermittent hypoxemia and OSA: implications for comorbidities. Chest. 2015;147:266–74.
Article PubMed PubMed Central Google Scholar
Dacal Quintas R, Tumbeiro Novoa M, Alves Perez MT, Santalla Martinez ML, Acuna Fernandez A, Marcos Velazquez P. Obstructive sleep apnea in normal weight patients: characteristics and comparison with overweight and obese patients. Archiv Bronconeumol. 2013;49:513–7.
Lecube A, de Hollanda A, Calanas A, Vilarrasa N, Rubio MA, Breton I, et al. Trends in bariatric surgery in spain in the twenty-first century: baseline results and 1-month follow up of the RICIBA, a National Registry. Obesity Surg. 2016;26:1836–42.
Durán J, Esnaola S, Rubio R, Rubio R, Iztueta A. Obstructive sleep apnea-hypopnea and related clinical features in a population-based sample of subjects aged 30 to 70 yr. Am J Respir Crit Care Med. 2001;163:685–9.
Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328:1230–5.
Article PubMed CAS Google Scholar
Kolotkin RL, LaMonte MJ, Walker JM, Cloward TV, Davidson LE, Crosby RD. Predicting sleep apnea in bariatric surgery patients. Surg Obes Relat Dis. 2011;7:605–10.
Article PubMed PubMed Central Google Scholar
Freitas LS, Silveira AC, Martins FC, Costa-Hong V, Lebkuchen A, Cardozo KHM, et al. Severe obstructive sleep apnea is associated with circulating microRNAs related to heart failure, myocardial ischemia, and cancer proliferation. Sleep Breath. 2020;24:1463–72.
Yang X, Niu X, Xiao Y, Lin K, Chen X. MiRNA expression profiles in healthy OSAHS and OSAHS with arterial hypertension: potential diagnostic and early warning markers. Respir Res. 2018;19:194.
Article PubMed PubMed Central Google Scholar
Tian R, Wang J, Yan H, Wu J, Xu Q, Zhan X, et al. Differential expression of miR16 in glioblastoma and glioblastoma stem cells: their correlation with proliferation, differentiation, metastasis and prognosis. Oncogene 2017;36:5861–73.
Article PubMed PubMed Central CAS Google Scholar
Zhang HJ, Zhang YN, Teng ZY. Downregulation of miR16 protects H9c2(21) cells against hypoxia/reoxygenation damage by targeting CIAPIN1 and regulating the NFkappaB pathway. Mol Med Rep. 2019;20:3113–22.
PubMed PubMed Central CAS Google Scholar
Zeng Y, Zhang X, Kang K, Chen J, Wu Z, Huang J, et al. MicroRNA-223 attenuates hypoxia-induced vascular remodeling by targeting RhoB/MLC2 in pulmonary arterial smooth muscle cells. Sci Rep. 2016;6:24900.
Article PubMed PubMed Central CAS Google Scholar
Hijmans JG, Diehl KJ, Bammert TD, Kavlich PJ, Lincenberg GM, Greiner JJ, et al. Association between hypertension and circulating vascular-related microRNAs. J Hum Hypertens. 2018;32:440–7.
Article PubMed PubMed Central CAS Google Scholar
Kontaraki JE, Marketou ME, Zacharis EA, Parthenakis FI, Vardas PE. MicroRNA-9 and microRNA-126 expression levels in patients with essential hypertension: potential markers of target-organ damage. J Am Soc Hypertens. 2014;8:368–75.
Article PubMed CAS Google Scholar
Karolina DS, Tavintharan S, Armugam A, Sepramaniam S, Pek SL, Wong MT, et al. Circulating miRNA profiles in patients with metabolic syndrome. J Clin Endocrinol Metab. 2012;97:E2271–6.
Article PubMed CAS Google Scholar
Khalyfa A, Marin JM, Qiao Z, Rubio DS, Kheirandish-Gozal L, Gozal D. Plasma exosomes in OSA patients promote endothelial senescence: effect of long-term adherent continuous positive airway pressure. Sleep. 2020;43:zsz217.
Santamaria-Martos F, Benitez I, Ortega F, Zapater A, Giron C, Pinilla L, et al. Circulating microRNA profile as a potential biomarker for obstructive sleep apnea diagnosis. Sci Rep. 2019;9:13456.
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