Hippius H, Neundorfer G. The discovery of Alzheimer’s disease. Dialogues Clin Neurosci. 2003;5(1):101–8.
Goate A, Chartier-Harlin M-C, Mullan M, Brown J, Crawford F, Fidani L, et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease. Nature. 1991;349(6311):704–6. https://doi.org/10.1038/349704a0.
Article CAS PubMed Google Scholar
Hardy JA, Higgins GA. Alzheimer’s disease: the amyloid cascade hypothesis. Science. 1992;256(5054):184–5. https://doi.org/10.1126/science.1566067.
Article CAS PubMed Google Scholar
Selkoe DJ. Alzheimer’s disease: a central role for amyloid. J Neuropathol Exp Neurol. 1994;53(5):438–47. https://doi.org/10.1097/00005072-199409000-00003.
Article CAS PubMed Google Scholar
Pike CJ, Overman MJ, Cotman CW. Amino-terminal deletions enhance aggregation of β-amyloid peptides in vitro. J Biol Chem. 1995;270(41):23895–8. https://doi.org/10.1074/jbc.270.41.23895.
Article CAS PubMed Google Scholar
Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron. 1994;13(1):45–53. https://doi.org/10.1016/0896-6273(94)90458-8.
Article CAS PubMed Google Scholar
Niwa K, Carlson GA, Iadecola C. Exogenous Aβ1–40 reproduces cerebrovascular alterations resulting from amyloid precursor protein overexpression in mice. J Cereb Blood Flow Metab. 2000;20(12):1659–68. https://doi.org/10.1097/00004647-200012000-00005.
Article CAS PubMed Google Scholar
Gomis M, Sobrino TS, Ois A, MilláN MN, RodríGuez-Campello A, De La Ossa NPR, et al. Plasma β-amyloid 1–40 is associated with the diffuse small vessel disease subtype. Stroke. 2009;40(10):3197–201. https://doi.org/10.1161/strokeaha.109.559641.
Article CAS PubMed Google Scholar
Solomon B, Koppel R, Hanan E, Katzav T. Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide. Proc Natl Acad Sci. 1996;93(1):452–5. https://doi.org/10.1073/pnas.93.1.452.
Article CAS PubMed PubMed Central Google Scholar
Solomon B, Koppel R, Frankel D, Hanan-Aharon E. Disaggregation of Alzheimer beta-amyloid by site-directed mAb. Proc Natl Acad Sci U S A. 1997;94(8):4109–12. https://doi.org/10.1073/pnas.94.8.4109.
Article CAS PubMed PubMed Central Google Scholar
Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature. 1999;400(6740):173–7. https://doi.org/10.1038/22124. This paper is the first article showing effective immunization procedures to clear Aβ plaques in mice.
Article CAS PubMed Google Scholar
Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, et al. Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer’s disease. Nature. 2000;408(6815):982–5. https://doi.org/10.1038/35050116.
Article CAS PubMed Google Scholar
Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD, et al. Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer’s disease. Nature. 2000;408(6815):979–82. https://doi.org/10.1038/35050110.
Article CAS PubMed Google Scholar
Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, et al. Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem. 2001;276(24):21562–70. https://doi.org/10.1074/jbc.M100710200.
Article CAS PubMed Google Scholar
Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med. 2000;6(8):916–9. https://doi.org/10.1038/78682. The authors show the first murine demonstration that peripheral immunization of anti-Aβ antibodies can cross the cerebrovasculature to mitigate Aβ plaque.
Article CAS PubMed Google Scholar
Vidarsson G, Dekkers G, Rispens T. IgG subclasses and allotypes: from structure to effector functions. Front Immunol. 2014;5:520. https://doi.org/10.3389/fimmu.2014.00520.
Article CAS PubMed PubMed Central Google Scholar
De Taeye SW, Rispens T, Vidarsson G. The ligands for human IgG and their effector functions. Antibodies. 2019;8(2):30. https://doi.org/10.3390/antib8020030.
Article CAS PubMed Central Google Scholar
Bacskai BJ, Kajdasz ST, McLellan ME, Games D, Seubert P, Schenk D, et al. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J Neurosci. 2002;22(18):7873–8.
Bard F, Barbour R, Cannon C, Carretto R, Fox M, Games D, et al. Epitope and isotype specificities of antibodies to β-amyloid peptide for protection against Alzheimer’s disease-like neuropathology. Proc Natl Acad Sci. 2003;100(4):2023–8. https://doi.org/10.1073/pnas.0436286100.
Article CAS PubMed PubMed Central Google Scholar
Lightle S, Aykent S, Lacher N, Mitaksov V, Wells K, Zobel J, et al. Mutations within a human IgG2 antibody form distinct and homogeneous disulfide isomers but do not affect Fc gamma receptor or C1q binding. Protein Sci. 2010;19(4):753–62. https://doi.org/10.1002/pro.352.
Article CAS PubMed PubMed Central Google Scholar
Wilcock DM, DiCarlo G, Henderson D, Jackson J, Clarke K, Ugen KE, et al. Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation. J Neurosci. 2003;23(9):3745–51.
Wilcock DM, Munireddy SK, Rosenthal A, Ugen KE, Gordon MN, Morgan D. Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration. Neurobiol Dis. 2004;15(1):11–20. https://doi.org/10.1016/j.nbd.2003.09.015.
Article CAS PubMed Google Scholar
DeWitt DA, Perry G, Cohen M, Doller C, Silver J. Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer’s disease. Exp Neurol. 1998;149(2):329–40. https://doi.org/10.1006/exnr.1997.6738.
Article CAS PubMed Google Scholar
Wyss-Coray T, Loike JD, Brionne TC, Lu E, Anankov R, Yan F, et al. Adult mouse astrocytes degrade amyloid-beta in vitro and in situ. Nat Med. 2003;9(4):453–7. https://doi.org/10.1038/nm838.
Article CAS PubMed Google Scholar
DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer’s disease. Proc Natl Acad Sci U S A. 2001;98(15):8850–5. https://doi.org/10.1073/pnas.151261398.
Article CAS PubMed PubMed Central Google Scholar
DeMattos RB, Bales KR, Cummins DJ, Paul SM, Holtzman DM. Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer’s disease. Science. 2002;295(5563):2264–7. https://doi.org/10.1126/science.1067568.
Article CAS PubMed Google Scholar
Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, Staufenbiel M, et al. Cerebral hemorrhage after passive anti-Abeta immunotherapy. Science. 2002;298(5597):1379. https://doi.org/10.1126/science.1078259.
Article CAS PubMed Google Scholar
Wilcock DM, Rojiani A, Rosenthal A, Subbarao S, Freeman MJ, Gordon MN, et al. Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage. J Neuroinflammation. 2004;1(1):24. https://doi.org/10.1186/1742-2094-1-24.
Article CAS PubMed PubMed Central Google Scholar
Racke MM, Boone LI, Hepburn DL, Parsadainian M, Bryan MT, Ness DK, et al. Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta. J Neurosci. 2005;25(3):629–36. https://doi.org/10.1523/JNEUROSCI.4337-04.2005.
Article CAS PubMed PubMed Central Google Scholar
Jellinger KA. Alzheimer disease and cerebrovascular pathology: an update. J Neural Transm. 2002;109(5–6):813–36. https://doi.org/10.1007/s007020200068.
Article CAS PubMed Google Scholar
Janota C, Lemere CA, Brito MA. Dissecting the contribution of vascular alterations and aging to Alzheimer’s disease. Mol Neurobiol. 2016;53(6):3793–811. https://doi.org/10.1007/s12035-015-9319-7.
Article CAS PubMed Google Scholar
Schenk D. Amyloid-β immunotherapy for Alzheimer’s disease: the end of the beginning. Nat Rev Neurosci. 2002;3(10):824–8. https://doi.org/10.1038/nrn938.
Article CAS PubMed Google Scholar
Buckwalter MS, Coleman BS, Buttini M, Barbour R, Schenk D, Games D, et al. Increased T cell recruitment to the CNS after amyloid beta1-42 immunization in Alzheimer’s mice overproducing transforming growth factor-beta1. J Neurosci. 2006;26(44):11437–41. https://doi.org/10.1523/jneurosci.2436-06.2006.
Article CAS PubMed PubMed Central Google Scholar
Ferrer I, Rovira MB, Guerra
留言 (0)