Almanza A, Carlesso A, Chintha C, Creedican S, Doultsinos D, Leuzzi B et al (2019) Endoplasmic reticulum stress signaling—from basic mechanisms to clinical applications. FEBS J 286:241–278. https://doi.org/10.1111/febs.14608
Article CAS PubMed Google Scholar
Andersen TB, Lopez CQ, Manczak T, Martinez K, Simonsen HT (2015) Thapsigargin–from Thapsia L. to mipsagargin. Molecules 20:6113–6127. https://doi.org/10.3390/molecules20046113
Article CAS PubMed PubMed Central Google Scholar
Ascierto PA, Flaherty K, Goff S (2018) Emerging strategies in systemic therapy for the treatment of melanoma. Am Soc Clin Oncol Educ Book 38:751–758. https://doi.org/10.1200/EDBK_199047
Ashton JC (2015) Drug combination studies and their synergy quantification using the Chou-Talalay method -letter. Cancer Res 75:2400. https://doi.org/10.1158/0008-5472.CAN-14-3763
Article CAS PubMed Google Scholar
Azijli K, Stelloo E, Peters GJ, Vde AJ (2014) New developments in the treatment of metastatic melanoma: immune checkpoint inhibitors and targeted therapies. Anticancer Res 34:1493–1505
Barrionuevo E, Cayrol F, Cremaschi GA, Cornier PG, Boggián DB, Delpiccolo CML, Mata EG, Roguin LP, Blank VC (2020) A penicillin derivative exerts an anti-metastatic activity in melanoma cells through the downregulation of integrin αvβ3 and Wnt/ β-catenin pathway. Front Pharmacol 11:127. https://doi.org/10.3389/fphar.2020.00127
Article CAS PubMed PubMed Central Google Scholar
Bellizzi Y, AnselmiRelats JM, Cornier PG, Delpiccolo CML, Mata EG, Cayrol F, Cremaschi GA, Blank VC, Roguin LP (2022) Contribution of endoplasmic reticulum stress, MAPK and PI3K/Akt pathways to the apoptotic death induced by a penicillin derivative in melanoma cells. Apoptosis 27:34–48. https://doi.org/10.1007/s10495-021-01697-7
Article CAS PubMed Google Scholar
Blank V, Bellizzi Y, Zotta E, Cornier PG, Delpiccolo CML, Boggián DB, Mata EG, Roguin LP (2018) A novel penicillin derivative induces antitumor effect in melanoma cells. Anticancer Drugs 29:416–428. https://doi.org/10.1097/CAD.0000000000000611
Article CAS PubMed Google Scholar
Chen LH, Jiang CC, Kiejda KA, Wang YF, Thorne RF, Zhang XD, Hersey P (2007) Thapsigargin sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-R2 through the unfolded protein response. Carcinogenesis 28:2328–2336. https://doi.org/10.1093/carcin/bgm173
Article CAS PubMed Google Scholar
Chen D, Liu X, Yang Y, Yang H, Pen L (2015) Systematic synergy modeling: understanding drug synergy from a systems biology perspective. BMC Syst Biol 9:56. https://doi.org/10.1186/s12918-015-0202-y
Article CAS PubMed PubMed Central Google Scholar
Chen Y, Li H, Zhang G, Wu Y, Xiao J, Liu J, Qiu P, Liu X, Sun L, Du B, Tan Y (2020) Synergistic inhibitory effect of resveratrol and TK/GCV therapy on melanoma cells. J Cancer Res Clin Oncol 146:1489–1499. https://doi.org/10.1007/s00432-020-03203-z
Article CAS PubMed Google Scholar
Chiarante N, Duhalde Vega M, Valli F, Zotta E, Daghero H, Basika T, Bollati-Fogolin M, García Vior MC, Marino J, Roguin LP (2020) In vivo photodynamic therapy with a lipophilic zinc(II) phthalocyanine inhibits colorectal cancer and induces a Th1/CD8 antitumor immune response. Lasers Surg Med 53:344–358. https://doi.org/10.1002/lsm.23284
Chou TC (2010) Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res 70:440–446. https://doi.org/10.1158/0008-5472.CAN-09-1947
Article CAS PubMed Google Scholar
Christensen SB, Skytte DM, Denmeade SR, Dionne C, Møller JV, Nissen P, Isaacs JT (2009) A Trojan horse in drug development: targeting of thapsigargins towards prostate cancer cells. Anticancer Agents Med Chem 9:276–294. https://doi.org/10.2174/1871520610909030276
Article CAS PubMed Google Scholar
Cornier PG, Delpiccolo CML, Mascali F, Boggián DB, Mata EG, Cárdenas M, Blank V, Roguin LP (2014) In vitro anticancer activity and SAR studies of triazolyl aminoacyl(peptidyl) penicillins. Med Chem Commun 5:214–218. https://doi.org/10.1039/C3MD00332A
Doan NT, Paulsen ES, Sehgal P, Møller JV, Nissen P, Denmeade SR, Isaacs JT, Dionne CA, Christensen SB (2015) Targeting thapsigargin towards tumors. Steroids 97:2–7. https://doi.org/10.1016/j.steroids.2014.07.009
Article CAS PubMed Google Scholar
Dorasamy MS, Ab A, Nellore K, Wong PF (2019) Synergistic inhibition of melanoma xenografts by brequinar sodium and doxorubicin. Biomed Pharmacother 110:29–36. https://doi.org/10.1016/j.biopha.2018.11.010
Article CAS PubMed Google Scholar
Foucquier J, Guedj M (2015) Analysis of drug combinations: current methodological landscape. Pharmacol Res Perspect 3:e00149. https://doi.org/10.1002/prp2.149
Article PubMed PubMed Central Google Scholar
Ghosh S, Adhikary A, Chakraborty S, Bhattacharjee P, Mazumder M, Putatunda S, Gorain M, Chakraborty A, Kundu GC, Das T, Sen PC (2015) Cross-talk between endoplasmic reticulum (ER) stress and the MEK/ERK pathway potentiates apoptosis in human triple negative breast carcinoma cells: role of a dihydropyrimidone, nifetepimine. J B Chem 290:3936–3949. https://doi.org/10.1074/jbc.M114.594028
Gowda R, Sharma A, Robertson GP (2017) Synergistic inhibitory effects of Celecoxib and Plumbagin on melanoma tumor growth. Cancer Lett 385:243–250. https://doi.org/10.1016/j.canlet.2016.10.016
Article CAS PubMed Google Scholar
Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, Wolchok JD, Hersey P, Joseph RW, Weber JS et al (2013) Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 369:134–144. https://doi.org/10.1056/NEJMoa1305133
Article CAS PubMed PubMed Central Google Scholar
Hassa PO, Hottiger MO (2008) The Diverse biological roles of mammalian PARPs, a small but powerful family of poly-ADP-ribose polymerases. Front Biosci 13:3046–3082. https://doi.org/10.2741/2909
Article CAS PubMed Google Scholar
He Q, Lee DI, Rong R, Yu M, Luo X, Klein M, El-Deiry WS, Huang Y, Hussain A, Sheikh MS (2002) Endoplasmic reticulum calcium pool depletion-induced apoptosis is coupled with activation of the death receptor 5 pathway. Oncogene 21:2623–2633. https://doi.org/10.1038/sj.onc.1205345
Article CAS PubMed Google Scholar
Huang L, Xu J, Li K, Zheng MH, Kumta SM (2004) Thapsigargin potentiates TRAIL-induced apoptosis in giant cell tumor of bone. Bone 34:971–981. https://doi.org/10.1016/j.bone.2004.02.005
Article CAS PubMed Google Scholar
Jia J, Zhu F, Ma X, Cao Z, Cao ZW, Li Y, Li YX, Chen YZ (2009) Mechanisms of drug combinations: interaction and network perspectives. Nat Rev Drug Discov 8:111–128. https://doi.org/10.1038/nrd2683
Article CAS PubMed Google Scholar
Landegren UJ (1984) Measurement of cell numbers by means of the endogenous enzyme hexosaminidase. Applications to detection of lymphokines and cell surface antigens. J Immunol Methods 67:379–388. https://doi.org/10.1016/0022-1759(84)90477-0
Article CAS PubMed Google Scholar
Lopez MV, Viale DL, Cafferata EGA, Bravo AI, Carbone C, Gould D, Chernajovsky Y, Podhajcer OL (2009) Tumor associated stromal cells play a critical role on the outcome of the oncolytic efficacy of conditionally replicative adenoviruses. PLoS ONE 4:e5119. https://doi.org/10.1371/journal.pone.0005119
Article CAS PubMed PubMed Central Google Scholar
Margue C, Philippidou D, Kozar I, Cesi G, Felten P, Kulms D, Letellier E, Haan C, Kreis SJ (2019) Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells. Exp Clin Cancer Res 38:56. https://doi.org/10.1186/s13046-019-1038-x
McKean MA, Amaria RN (2018) Multidisciplinary treatment strategies in high-risk resectable melanoma: role of adjuvant and neoadjuvant therapy. Rev Cancer Treat Rev 70:144–153. https://doi.org/10.1016/j.ctrv.2018.08.011
Article CAS PubMed Google Scholar
Nowicki TS, Hu-Lieskovan S, Ribas A (2018) Mechanisms of resistance to PD-1 and PD-L1 blockade. Cancer J 24:47–53. https://doi.org/10.1097/PPO.0000000000000303
Article CAS PubMed PubMed Central Google Scholar
Oakes S, Papa FR (2015) The role of endoplasmic reticulum stress in human pathology. Annu Rev Pathol 10:173–194. https://doi.org/10.1146/annurev-pathol-012513-104649
Article CAS PubMed Google Scholar
Rodríguez-Hernández Á, Brea-Calvo G, Fernández-Ayala DJM, Cordero M, Navas P, Sánchez-Alcázar JA (2006) Nuclear caspase-3 and capase-7 activation, and Poly(ADP-Ribose) polymerase cleavage are early events in camptothecin-induced apoptosis. Apoptosis 11:131–139. https://doi.org/10.1007/s10495-005-3276-y
Article CAS PubMed Google Scholar
Rughani MG, Gupta A, Middleton MR (2013) New treatment approaches in melanoma: current research and clinical prospects. Ther Adv Med Oncol 5:73–80. https://doi.org/10.1177/1758834012463260
Article CAS PubMed PubMed Central Google Scholar
Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, Gunnison KM, Mori K, Akha AAS, Raden D, Kaufman RJ (2006) Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol 4(11):e374. https://doi.org/10.1371/journal.pbio.0040374
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