aBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Korea

bDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea

cCollege of Pharmacy, Seoul National University, Seoul, Korea

dCollege of Pharmacy, Gachon University, Incheon, Korea

eSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States

fMolecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London, United Kingdom

*Corresponding author. Address: L7 L7412, Brain Science Institute, Korea Institute of Science and Technology, 5 Hwarang-ro 14gil, Seongbuk-gu, Seoul 02792, Korea. Tel.: +82-2-958-7031; fax: +82-2-958-7035. E-mail address: [email protected] (U. Oh).

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H. Kim and H. Kim contributed equally to this work.