Campbell, I. J., Bennett, G. N. & Silberg, J. J. Evolutionary relationships between low potential ferredoxin and flavodoxin electron carriers. Front. Energy Res. https://doi.org/10.3389/fenrg.2019.00079 (2019).
Hanke, G. & Mulo, P. Plant type ferredoxins and ferredoxin-dependent metabolism. Plant Cell Environ. 36, 1071–1084 (2013).
Miotto, O. et al. Genetic architecture of artemisinin-resistant Plasmodium falciparum. Nat. Genet. 47, 226–234 (2015).
CAS PubMed PubMed Central Google Scholar
Changmai, P. et al. Both human ferredoxins equally efficiently rescue ferredoxin deficiency in Trypanosoma brucei. Mol. Microbiol. 89, 135–151 (2013).
Ewen, K. M., Ringle, M. & Bernhardt, R. Adrenodoxin–a versatile ferredoxin. IUBMB Life 64, 506–512 (2012).
Sheftel, A. D. et al. Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis. Proc. Natl Acad. Sci. USA 107, 11775–11780 (2010).
CAS PubMed PubMed Central Google Scholar
Lange, H., Kaut, A., Kispal, G. & Lill, R. A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins. Proc. Natl Acad. Sci. USA 97, 1050–1055 (2000).
CAS PubMed PubMed Central Google Scholar
Shi, Y., Ghosh, M., Kovtunovych, G., Crooks, D. R. & Rouault, T. A. Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis. Biochim. Biophys. Acta 1823, 484–492 (2012).
Webert, H. et al. Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin. Nat. Commun. 5, 5013 (2014).
Freibert, S. A. et al. Evolutionary conservation and in vitro reconstitution of microsporidian iron-sulfur cluster biosynthesis. Nat. Commun. 8, 13932 (2017).
CAS PubMed PubMed Central Google Scholar
Braymer, J. J., Freibert, S. A., Rakwalska-Bange, M. & Lill, R. Mechanistic concepts of iron-sulfur protein biogenesis in Biology. Biochim. Biophys. Acta, Mol. Cell. Res. 1868, 118863 (2021).
Kispal, G., Csere, P., Prohl, C. & Lill, R. The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins. EMBO J. 18, 3981–3989 (1999).
CAS PubMed PubMed Central Google Scholar
Boniecki, M. T., Freibert, S. A., Muhlenhoff, U., Lill, R. & Cygler, M. Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. Nat. Commun. 8, 1287 (2017).
PubMed PubMed Central Google Scholar
Van Vranken, J. G. et al. The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis. eLife 5, e17828 (2016).
PubMed PubMed Central Google Scholar
Kim, J. H., Frederick, R. O., Reinen, N. M., Troupis, A. T. & Markley, J. L. [2Fe-2S]-Ferredoxin binds directly to cysteine desulfurase and supplies an electron for iron-sulfur cluster assembly but is displaced by the scaffold protein or bacterial frataxin. J. Am. Chem. Soc. 15, 8117–8120 (2013).
Gervason, S. et al. Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin. Nat. Commun. 10, 3566 (2019).
PubMed PubMed Central Google Scholar
Freibert, S. A. et al. N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization. Nat. Commun. 12, 6902 (2021).
CAS PubMed PubMed Central Google Scholar
Weiler, B. D. et al. Mitochondrial [4Fe-4S] protein assembly involves reductive [2Fe-2S] cluster fusion on ISCA1-ISCA2 by electron flow from ferredoxin FDX2. Proc. Natl Acad. Sci. USA 117, 20555–20565 (2020).
CAS PubMed PubMed Central Google Scholar
Lill, R. & Freibert, S. A. Mechanisms of mitochondrial iron-sulfur protein biogenesis. Annu. Rev. Biochem. 89, 471–499 (2020).
Zhang, Y. et al. Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2. Genes Dev. 31, 1243–1256 (2017).
CAS PubMed PubMed Central Google Scholar
Barros, M. H., Carlson, C. G., Glerum, D. M. & Tzagoloff, A. Involvement of mitochondrial ferredoxin and Cox15p in hydroxylation of heme O. FEBS Lett. 492, 133–138 (2001).
Bareth, B. et al. The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturation. Mol. Cell. Biol. 33, 4128–4137 (2013).
CAS PubMed PubMed Central Google Scholar
Swenson, S. A. et al. From synthesis to utilization: the ins and outs of mitochondrial heme. Cells 9, 579 (2020).
CAS PubMed Central Google Scholar
Ozeir, M. et al. Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency. Chem. Biol. 18, 1134–1142 (2011).
Cai, K., Tonelli, M., Frederick, R. O. & Markley, J. L. Human mitochondrial Ferredoxin 1 (FDX1) and Ferredoxin 2 (FDX2) both bind cysteine desulfurase and donate electrons for iron-sulfur cluster biosynthesis. Biochemistry 56, 487–499 (2017).
Landgraf, B. J., McCarthy, E. L. & Booker, S. J. Radical S-adenosylmethionine enzymes in human health and disease. Annu. Rev. Biochem. 85, 485–514 (2016).
Cronan, J. E. Assembly of lipoic acid on its cognate enzymes: an extraordinary and essential biosynthetic pathway. Microbiol Mol. Biol. Rev. 80, 429–450 (2016).
CAS PubMed PubMed Central Google Scholar
Zhu, J. & Thompson, C. B. Metabolic regulation of cell growth and proliferation. Nat. Rev. Mol. Cell Biol. 20, 436–450 (2019).
CAS PubMed PubMed Central Google Scholar
Tsvetkov, P. et al. Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat. Chem. Biol. 15, 681–689 (2019).
CAS PubMed PubMed Central Google Scholar
Tsvetkov, P. et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science 375, 1254–1261 (2022).
CAS PubMed PubMed Central Google Scholar
Campbell, I. J. et al. Recombination of 2Fe-2S ferredoxins reveals differences in the inheritance of thermostability and midpoint potential. ACS Synth. Biol. 9, 3245–3253 (2020).
Antonicka, H. et al. Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy. Am. J. Hum. Genet. 72, 101–114 (2003).
Sheftel, A. D. et al. The human mitochondrial ISCA1, ISCA2, and IBA57 proteins are required for [4Fe-4S] protein maturation. Mol. Biol. Cell 23, 1157–1166 (2012).
CAS PubMed PubMed Central Google Scholar
McCarthy, E. L. & Booker, S. J. Destruction and reformation of an iron-sulfur cluster during catalysis by lipoyl synthase. Science 358, 373–377 (2017).
CAS PubMed PubMed Central Google Scholar
Nagai, M. et al. The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells. Free Radic. Biol. Med 52, 2142–2150 (2012).
Soma, S. et al. Elesclomol restores mitochondrial function in genetic models of copper deficiency. Proc. Natl Acad. Sci. USA 115, 8161–8166 (2018).
CAS PubMed PubMed Central Google Scholar
Hasinoff, B. B., Yadav, A. A., Patel, D. & Wu, X. The cytotoxicity of the anticancer drug elesclomol is due to oxidative stress indirectly mediated through its complex with Cu(II). J. Inorg. Biochem. 137, 22–30 (2014).
Yadav, A. A., Patel, D., Wu, X. & Hasinoff, B. B. Molecular mechanisms of the biological activity of the anticancer drug elesclomol and its complexes with Cu(II), Ni(II) and Pt(II). J. Inorg. Biochem. 126, 1–6 (2013).
Vallieres, C., Holland, S. L. & Avery, S. V. Mitochondrial ferredoxin determines vulnerability of cells to copper excess. Cell Chem. Biol. 24, 1228–1237 e3 (2017).
CAS PubMed PubMed Central Google Scholar
Mühlenhoff, U. et al. Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster. Cell Metab. 12, 373–385 (2010).
PubMed PubMed Central Google Scholar
Schiffler, B. et al. The adrenodoxin-like ferredoxin of Schizosaccharomyces pombe mitochondria. J. Inorg. Biochem. 98, 1229–1237 (2004).
Muller, J. J. et al. Structural and thermodynamic characterization of the adrenodoxin-like domain of the electron-transfer protein Etp1 from Schizosaccharomyces pombe. J. Inorg. Biochem. 105, 957–965 (2011).
Omura, T. & Gotoh, O. Evolutionary origin of mitochondrial cytochrome P450. J. Biochem. 161, 399–407 (2017).
Kimura, T. & Suzuki, K. Components of the electron transport system in adrenal steroid hydroxylase
留言 (0)