Bell GS, Sander JW: The epidemiology of epilepsy: the size of the problem. Seizure 2001, 10(4):306–314; quiz 315–306.
Bien CG, Kurthen M, Baron K, Lux S, Helmstaedter C, Schramm J, Elger CE (2001) Long-term seizure outcome and antiepileptic drug treatment in surgically treated temporal lobe epilepsy patients: a controlled study. Epilepsia 42(11):1416–1421
Mitchell JW, Seri S, Cavanna AE (2012) Pharmacotherapeutic and Non-Pharmacological Options for Refractory and Difficult-to-Treat Seizures. Journal of central nervous system disease 4:105–115
PubMed PubMed Central Google Scholar
Legido A, Katsetos CD (2014) Experimental studies in epilepsy: immunologic and inflammatory mechanisms. Seminars in pediatric neurology 21(3):197–206
Noebels J (2015) Pathway-driven discovery of epilepsy genes. Nat Neurosci 18(3):344–350
CAS PubMed PubMed Central Google Scholar
Patel DC, Tewari BP, Chaunsali L, Sontheimer H: Neuron-glia interactions in the pathophysiology of epilepsy. Nat Rev Neurosci 2019.
Hackett AR, Lee JK (2016) Understanding the NG2 Glial Scar after Spinal Cord Injury. Front Neurol 7:199
PubMed PubMed Central Google Scholar
Levine JM, Reynolds R, Fawcett JW (2001) The oligodendrocyte precursor cell in health and disease. Trends Neurosci 24(1):39–47
McTigue DM, Wei P, Stokes BT (2001) Proliferation of NG2-positive cells and altered oligodendrocyte numbers in the contused rat spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience 21(10):3392–3400
Lytle JM, Wrathall JR (2007) Glial cell loss, proliferation and replacement in the contused murine spinal cord. Eur J Neurosci 25(6):1711–1724
Tripathi R, McTigue DM (2007) Prominent oligodendrocyte genesis along the border of spinal contusion lesions. Glia 55(7):698–711
Zai LJ, Wrathall JR (2005) Cell proliferation and replacement following contusive spinal cord injury. Glia 50(3):247–257
Geha S, Pallud J, Junier MP, Devaux B, Leonard N, Chassoux F, Chneiweiss H, Daumas-Duport C, Varlet P (2010) NG2+/Olig2+ cells are the major cycle-related cell population of the adult human normal brain. Brain Pathol 20(2):399–411
Luo Y, Hu Q, Zhang Q, Hong S, Tang X, Cheng L, Jiang L (2015) Alterations in hippocampal myelin and oligodendrocyte precursor cells during epileptogenesis. Brain Res 1627:154–164
Scanlon C, Mueller SG, Cheong I, Hartig M, Weiner MW, Laxer KD (2013) Grey and white matter abnormalities in temporal lobe epilepsy with and without mesial temporal sclerosis. J Neurol 260(9):2320–2329
Bardehle S, Kruger M, Buggenthin F, Schwausch J, Ninkovic J, Clevers H, Snippert HJ, Theis FJ, Meyer-Luehmann M, Bechmann I et al: Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation. Nature neuroscience 2013, 16(5):580-+.
Sosunov AA, Wu XP, Tsankova NM, Guilfoyle E, McKhann GM, Goldman JE (2014) Phenotypic Heterogeneity and Plasticity of Isocortical and Hippocampal Astrocytes in the Human Brain. J Neurosci 34(6):2285–2298
CAS PubMed PubMed Central Google Scholar
Sosunov AA, McGovern RA, Mikell CB, Wu XP, Coughlin DG, Crino PB, Weiner HL, Ghatan S, Goldman JE, McKhann GM: Epileptogenic but MRI-normal perituberal tissue in Tuberous Sclerosis Complex contains tuber-specific abnormalities. Acta Neuropathol Com 2015, 3.
Bedner P, Dupper A, Huttmann K, Muller J, Herde MK, Dublin P, Deshpande T, Schramm J, Haussler U, Haas CA et al (2015) Astrocyte uncoupling as a cause of human temporal lobe epilepsy. Brain : a journal of neurology 138(Pt 5):1208–1222
Steinhauser C, Grunnet M, Carmignoto G: Crucial role of astrocytes in temporal lobe epilepsy. Neuroscience 2015.
Mitchell A, Roussos P, Peter C, Tsankova N, Akbarian S (2014) The future of neuroepigenetics in the human brain. Prog Mol Biol Transl Sci 128:199–228
PubMed PubMed Central Google Scholar
Jiang Y, Matevossian A, Huang HS, Straubhaar J, Akbarian S (2008) Isolation of neuronal chromatin from brain tissue. BMC Neurosci 9:42
PubMed PubMed Central Google Scholar
Matevossian A, Akbarian S: Neuronal nuclei isolation from human postmortem brain tissue. Journal of visualized experiments : JoVE 2008(20).
Psych EC, Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S et al (2015) The PsychENCODE project. Nat Neurosci 18(12):1707–1712
Cheung I, Shulha HP, Jiang Y, Matevossian A, Wang J, Weng Z, Akbarian S (2010) Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex. Proc Natl Acad Sci USA 107(19):8824–8829
CAS PubMed PubMed Central Google Scholar
Shulha HP, Crisci JL, Reshetov D, Tushir JS, Cheung I, Bharadwaj R, Chou HJ, Houston IB, Peter CJ, Mitchell AC et al (2012) Human-specific histone methylation signatures at transcription start sites in prefrontal neurons. PLoS Biol 10(11):e1001427
CAS PubMed PubMed Central Google Scholar
Sun W, Cornwell A, Li J, Peng S, Osorio MJ, Aalling N, Wang S, Benraiss A, Lou N, Goldman SA et al (2017) SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions. J Neurosci 37(17):4493–4507
CAS PubMed PubMed Central Google Scholar
Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M, Gingeras TR (2013) STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29(1):15–21
Liao Y, Smyth GK, Shi W (2014) featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30(7):923–930
Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15(12):550
PubMed PubMed Central Google Scholar
Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK (2010) Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell 38(4):576–589
CAS PubMed PubMed Central Google Scholar
da Huang W, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4(1):44–57
Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102(43):15545–15550
CAS PubMed PubMed Central Google Scholar
Zheng GX, Terry JM, Belgrader P, Ryvkin P, Bent ZW, Wilson R, Ziraldo SB, Wheeler TD, McDermott GP, Zhu J et al (2017) Massively parallel digital transcriptional profiling of single cells. Nat Commun 8:14049
CAS PubMed PubMed Central Google Scholar
Hao Y, Hao S, Andersen-Nissen E, Mauck WM, 3rd, Zheng S, Butler A, Lee MJ, Wilk AJ, Darby C, Zager M et al: Integrated analysis of multimodal single-cell data. Cell 2021, 184(13):3573–3587 e3529.
van den Brink SC, Sage F, Vertesy A, Spanjaard B, Peterson-Maduro J, Baron CS, Robin C, van Oudenaarden A (2017) Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations. Nat Methods 14(10):935–936
Aran D, Looney AP, Liu L, Wu E, Fong V, Hsu A, Chak S, Naikawadi RP, Wolters PJ, Abate AR et al (2019) Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol 20(2):163–172
CAS PubMed PubMed Central Google Scholar
Harris JA, Mihalas S, Hirokawa KE, Whitesell JD, Choi H, Bernard A, Bohn P, Caldejon S, Casal L, Cho A et al (2019) Hierarchical organization of cortical and thalamic connectivity. Nature 575(7781):195–202
CAS PubMed PubMed Central Google Scholar
Darmanis S, Sloan SA, Zhang Y, Enge M, Caneda C, Shuer LM, Hayden Gephart MG, Barres BA, Quake SR (2015) A survey of human brain transcriptome diversity at the single cell level. Proc Natl Acad Sci U S A 112(23):7285–7290
CAS PubMed PubMed Central Google Scholar
Cao J, O'Day DR, Pliner HA, Kingsley PD, Deng M, Daza RM, Zager MA, Aldinger KA, Blecher-Gonen R, Zhang F et al: A human cell atlas of fetal gene expression. Science 2020, 370(6518).
Tome-Garcia J, Tejero R, Nudelman G, Yong RL, Sebra R, Wang H, Fowkes M, Magid M, Walsh M, Silva-Vargas V et al: Prospective Isolation and Comparison of Human Germinal Matrix and Glioblastoma EGFR+ Populations with Stem Cell Properties. Stem Cell Reports 2017.
Tome-Garcia JD, F.; Tsankova, N. M.: FACS-based Isolation of Neural and Glioma Stem Cell Populations from Fresh Human Tissues Utilizing EGF Ligand. Bio-protocol 2017, 7(24):e2659.
Rowitch DH, Lu QR, Kessaris N, Richardson WD (2002) An “oligarchy” rules neural development. Trends Neurosci 25(8):417–422
Lu QR, Yuk D, Alberta JA, Zhu Z, Pawlitzky I, Chan J, McMahon AP, Stiles CD, Rowitch DH (2000) Sonic hedgehog–regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron 25(2):317–329
Vallstedt A, Klos JM, Ericson J (2005) Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain. Neuron 45(1):55–67
Zhang Y, Sloan SA, Clarke LE, Caneda C, Plaza CA, Blumenthal PD, Vogel H, Steinberg GK, Edwards MS, Li G et al (2016) Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse. Neuron 89(1):37–53
Manuel MN, Mi D, Mason JO, Price DJ (2015) Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor. Front Cell Neurosci 9:70
PubMed PubMed Central Google Scholar
Cvekl A, Callaerts P (2017) PAX6: 25th anniversary and more to learn. Exp Eye Res 156:10–21
Matsumoto Y, Osumi N: [Role of Pax6 in the developing central nervous system]. Brain and nerve = Shinkei kenkyu no shinpo 2008, 60(4):365–374.
Sakurai K, Osumi N (2008) The neurogenesis-controlling factor, Pax6, inhibits proliferation and promotes maturation in murine astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience 28(18):4604–4612
Goc J, Liu JY, Sisodiya SM, Thom M (2014) A spatiotemporal study of gliosis in relation to depth electrode tracks in drug-resistant epilepsy. Eur J Neurosci 39(12):2151–2162
留言 (0)