Co-expression of DDR2 and IFITM1 promotes breast cancer cell proliferation, migration and invasion and inhibits apoptosis

Arnutti P, Kotepui M, Asanprakit W, Punyarit P, Chavalitshewinkoon-Petmitr P, Harnroongroj T, Petmitr S (2013) Determination of whole transcription profiles and specific pathways in invasive ductal breast carcinoma. Int J Clin Exp Pathol 6:1112–1120

CAS  PubMed  PubMed Central  Google Scholar 

Azemikhah M, Ashtiani HA, Aghaei M, Rastegar H (2015) Evaluation of discoidin domain receptor-2 (DDR2) expression level in normal, benign, and malignant human prostate tissues. Res Pharm Sci 10:356–363

PubMed  PubMed Central  Google Scholar 

Badiola I, Villace P, Basaldua I, Olaso E (2011) Downregulation of discoidin domain receptor 2 in A375 human melanoma cells reduces its experimental liver metastasis ability. Oncol Rep 26:971–978. https://doi.org/10.3892/or.2011.1356

Article  CAS  PubMed  Google Scholar 

Borg D et al (2016) Expression of IFITM1 as a prognostic biomarker in resected gastric and esophageal adenocarcinoma. Biomark Res. https://doi.org/10.1186/s40364-016-0064-5

Article  PubMed  PubMed Central  Google Scholar 

Deraz EM et al (2011) MMP-10/stromelysin-2 promotes invasion of head and neck cancer. PLoS One 6:e25438. https://doi.org/10.1371/journal.pone.0025438

Article  CAS  PubMed  PubMed Central  Google Scholar 

Escher TE, Lui AJ, Geanes ES, Walter KR, Tawfik O, Hagan CR, Lewis-Wambi J (2019) Interaction between MUC1 and STAT1 Drives IFITM1 overexpression in aromatase inhibitor-resistant breast cancer cells and mediates estrogen-induced apoptosis. Mol Cancer Res 17:1180–1194. https://doi.org/10.1158/1541-7786.MCR-18-0916

Article  CAS  PubMed  PubMed Central  Google Scholar 

Evans SS, Lee DB, Han T, Tomasi TB, Evans RL (1990) Monoclonal antibody to the interferon-inducible protein Leu-13 triggers aggregation and inhibits proliferation of leukemic B cells. Blood 76:2583–2593

Article  CAS  Google Scholar 

Fan Y et al (2016) Prognostic significance of discoidin domain receptor 2 (DDR2) expression in ovarian cancer. Am J Transl Res 8:2845–2850

CAS  PubMed  PubMed Central  Google Scholar 

Gherardini L et al (2021) The FHP01 DDX3X helicase inhibitor exerts potent anti-tumor activity in vivo in breast cancer pre-clinical models. Cancers (Basel) 13(19):4830

Article  CAS  Google Scholar 

Gschwind A, Fischer OM, Ullrich A (2004) The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer 4:361–370. https://doi.org/10.1038/nrc1360

Article  CAS  PubMed  Google Scholar 

Hatano H, Kudo Y, Ogawa I, Tsunematsu T, Kikuchi A, Abiko Y, Takata T (2008) IFN-induced transmembrane protein 1 promotes invasion at early stage of head and neck cancer progression. Clin Cancer Res 14:6097–6105. https://doi.org/10.1158/1078-0432.CCR-07-4761

Article  CAS  PubMed  Google Scholar 

He J, Li J, Feng W, Chen L, Yang K (2015) Prognostic significance of INF-induced transmembrane protein 1 in colorectal cancer. Int J Clin Exp Pathol 8:16007–16013

CAS  PubMed  PubMed Central  Google Scholar 

Herrera-Herrera ML, Quezada-Calvillo R (2012) DDR2 plays a role in fibroblast migration independent of adhesion ligand and collagen activated DDR2 tyrosine kinase. Biochem Biophys Res Commun 429:39–44. https://doi.org/10.1016/j.bbrc.2012.10.103

Article  CAS  PubMed  Google Scholar 

Huang C, Xu S, Luo Z, Li D, Wang R, Wang T (2022) Epidemiological evidence between variants in matrix metalloproteinases2, –7, and –9 and cancer risk. Front Oncol 12:856831. https://doi.org/10.3389/fonc.2022.856831

Article  PubMed  PubMed Central  Google Scholar 

Jafari SH et al (2018) Breast cancer diagnosis: imaging techniques and biochemical markers. J Cell Physiol 233:5200–5213. https://doi.org/10.1002/jcp.26379

Article  CAS  PubMed  Google Scholar 

Johnson MC, Sangrador-Vegas A, Smith TJ, Cairns MT (2006) Cloning and characterization of two genes encoding rainbow trout homologues of the IFITM protein family. Vet Immunol Immunopathol 110:357–362. https://doi.org/10.1016/j.vetimm.2005.12.007

Article  CAS  PubMed  Google Scholar 

Kim NH, Sung HY, Choi EN, Lyu D, Choi HJ, Ju W, Ahn JH (2014b) Aberrant DNA methylation in the IFITM1 promoter enhances the metastatic phenotype in an intraperitoneal xenograft model of human ovarian cancer. Oncol Rep 31:2139–2146

Article  CAS  Google Scholar 

Kim D, Ko P, You E, Rhee S (2014) The intracellular juxtamembrane domain of discoidin domain receptor 2 (DDR2) is essential for receptor activation and DDR2-mediated cancer progression. Int J Cancer 135:2547–2557. https://doi.org/10.1002/ijc.28901

Article  CAS  PubMed  Google Scholar 

Lee J et al (2012) Overexpression of IFITM1 has clinicopathologic effects on gastric cancer and is regulated by an epigenetic mechanism. Am J Pathol 181:43–52. https://doi.org/10.1016/j.ajpath.2012.03.027

Article  CAS  PubMed  Google Scholar 

Leitinger B (2014) Discoidin domain receptor functions in physiological and pathological conditions. Int Rev Cell Mol Biol 310:39–87. https://doi.org/10.1016/B978-0-12-800180-6.00002-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lemmon MA, Schlessinger J (2010) Cell signaling by receptor tyrosine kinases. Cell 141:1117–1134. https://doi.org/10.1016/j.cell.2010.06.011

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lewin AR, Reid LE, McMahon M, Stark GR, Kerr IM (1991) Molecular analysis of a human interferon-inducible gene family. Eur J Biochem 199:417–423. https://doi.org/10.1111/j.1432-1033.1991.tb16139.x

Article  CAS  PubMed  Google Scholar 

Li T, Mello-Thoms C, Brennan PC (2016) Descriptive epidemiology of breast cancer in China: incidence, mortality, survival and prevalence. Breast Cancer Res Treat 159:395–406. https://doi.org/10.1007/s10549-016-3947-0

Article  CAS  PubMed  Google Scholar 

Lui AJ et al (2017) IFITM1 suppression blocks proliferation and invasion of aromatase inhibitor-resistant breast cancer in vivo by JAK/STAT-mediated induction of p21. Cancer Lett 399:29–43. https://doi.org/10.1016/j.canlet.2017.04.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ogony J, Choi HJ, Lui A, Cristofanilli M, Lewis-Wambi J (2016) Interferon-induced transmembrane protein 1 (IFITM1) overexpression enhances the aggressive phenotype of SUM149 inflammatory breast cancer cells in a signal transducer and activator of transcription 2 (STAT2)-dependent manner. Breast Cancer Res 18:25. https://doi.org/10.1186/s13058-016-0683-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park JW et al (2015) Downregulation of discoidin domain receptor 2 decreases tumor growth of hepatocellular carcinoma. J Cancer Res Clin Oncol 141:1973–1983. https://doi.org/10.1007/s00432-015-1967-5

Article  CAS  PubMed  Google Scholar 

Parker JS et al (2009) Supervised risk predictor of breast cancer based on intrinsic subtypes. J Clin Oncol 27:1160–1167. https://doi.org/10.1200/JCO.2008.18.1370

Article  PubMed  PubMed Central  Google Scholar 

Poudel B, Lee YM, Kim DK (2015) DDR2 inhibition reduces migration and invasion of murine metastatic melanoma cells by suppressing MMP2/9 expression through ERK/NF-kappaB pathway. Acta Biochim Biophys Sin (Shanghai) 47:292–298. https://doi.org/10.1093/abbs/gmv005

Article  CAS  Google Scholar 

Ren T, Zhang J, Zhang J, Liu X, Yao L (2013) Increased expression of discoidin domain receptor 2 (DDR2): a novel independent prognostic marker of worse outcome in breast cancer patients. Med Oncol 30:397. https://doi.org/10.1007/s12032-012-0397-3

Article  CAS  PubMed  Google Scholar 

Ren T et al (2014) Discoidin domain receptor 2 (DDR2) promotes breast cancer cell metastasis and the mechanism implicates epithelial-mesenchymal transition programme under hypoxia. J Pathol 234:526–537. https://doi.org/10.1002/path.4415

Article  CAS  PubMed  Google Scholar 

Sasaki H et al (2012) DDR2 polymorphisms and mRNA expression in lung cancers of Japanese patients. Oncol Lett 4:33–37. https://doi.org/10.3892/ol.2012.684

Article  CAS  PubMed  PubMed Central  Google Scholar 

Siddhartha R, Garg M (2021) Molecular and clinical insights of matrix metalloproteinases into cancer spread and potential therapeutic interventions. Toxicol Appl Pharmacol 426:115593. https://doi.org/10.1016/j.taap.2021.115593

Article  CAS  PubMed  Google Scholar 

Siegel RL, Miller KD, Jemal A (2019) Cancer statistics. CA Cancer J Clin 69:7–34. https://doi.org/10.3322/caac.21551

Article  PubMed  Google Scholar 

Sivakumar L, Agarwal G (2010) The influence of discoidin domain receptor 2 on the persistence length of collagen type I fibers. Biomaterials 31:4802–4808. https://doi.org/10.1016/j.biomaterials.2010.02.070

Article  CAS  PubMed  Google Scholar 

Terashima M et al (2016) Functional analyses of mutations in receptor tyrosine kinase genes in non-small cell lung cancer: double-edged sword of DDR2. Clin Cancer Res 22:3663–3671. https://doi.org/10.1158/1078-0432.CCR-15-2093

Article  CAS  PubMed  Google Scholar 

Valiathan RR, Marco M, Leitinger B, Kleer CG, Fridman R (2012) Discoidin domain receptor tyrosine kinases: new players in cancer progression. Cancer Metastasis Rev 31:295–321. https://doi.org/10.1007/s10555-012-9346-z

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