Available online 20 October 2022, 100885

Azole resistance in Aspergillus fumigatus is a One Health resistance threat

Azole fungicide exposure compromises the efficacy of medical azoles

The fungicide Iplufenoquin shares its mode of action with a new antifungal olorofim

Dual use of antifungal compounds requires risk assessment for human pathogens

Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide iplufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for risk assessment for dual use of antifungals.

Aspergillus fumigatus

triazole resistance olorofim

DHODH inhibitor

One Health

© 2022 The Author(s). Published by Elsevier Ltd.