Hu, F. B. Resolved: there is sufficient scientific evidence that decreasing sugar-sweetened beverage consumption will reduce the prevalence of obesity and obesity-related diseases. Obes. Rev. 14, 606–619 (2013).

Article  CAS  Google Scholar 

Basson, A. R., Rodriguez-Palacios, A. & Cominelli, F. Artificial sweeteners: history and new concepts on inflammation. Front. Nutr. 8, 746247 (2021).

Article  Google Scholar 

Sylvetsky, A. C. et al. Consumption of low-calorie sweeteners among children and adults in the United States. J. Acad. Nutr. Diet. 117, 441–448 (2017).

Article  Google Scholar 

Lohner, S., Toews, I. & Meerpohl, J. J. Health outcomes of non-nutritive sweeteners: analysis of the research landscape. Nutr. J. 16, 55 (2017).

Article  Google Scholar 

Del Pozo, S. et al. Potential effects of sucralose and saccharin on gut microbiota: a review. Nutrients 14, 1682 (2022).

Article  Google Scholar 

Suez, J., Korem, T., Zilberman-Schapira, G., Segal, E. & Elinav, E. Non-caloric artificial sweeteners and the microbiome: findings and challenges. Gut Microbes 6, 149–155 (2015).

Article  CAS  Google Scholar 

Suez, J. et al. Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance. Cell 185, 3307–3328 (2022).

Article  CAS  Google Scholar 

Magnuson, B. A., Carakostas, M. C., Moore, N. H., Poulos, S. P. & Renwick, A. G. Biological fate of low-calorie sweeteners. Nutr. Rev. 74, 670–689 (2016).

Article  Google Scholar 

Fiehn, O. et al. Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PLoS ONE 5, e15234 (2010).

Article  Google Scholar 

Guasch-Ferre, M. et al. Glycolysis/gluconeogenesis- and tricarboxylic acid cycle-related metabolites, Mediterranean diet, and type 2 diabetes. Am. J. Clin. Nutr. 111, 835–844 (2020).

Article  Google Scholar